Publications by authors named "Tangcong Chen"
Gene therapy and gene editing strategies in inherited blood disorders.
J Genet Genomics
November 2024
Article Synopsis
- * BCL11A is identified as a key therapeutic target, and the gene therapy product Casgevy has received approval in the UK and USA in 2023 for its role in reducing BCL11A expression.
- * Innovative gene editing techniques, such as base and prime editing using CRISPR, enhance the precision of treatments for these disorders, paving the way for safer and more effective gene therapy options.
SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK-8 assessed cytotoxicity.
View Article and Find Full Text PDFIt has been shown that Tibetan tea (TT) inhibits obesity and controls lipid metabolism. The fundamental processes by which TT prevents obesity are yet entirely unknown. Consequently, this research aimed to ascertain if TT may prevent obesity by modifying the gut flora.
View Article and Find Full Text PDFObesity is a metabolic disease associated with gut microbiota and low-grade chronic inflammation. is a medicinal and edible fungus; polysaccharide (TP) is the main active component, which has a variety of biological activities, such as hypoglycemic and hypolipidemic. However, the anti-obesity effects and potential mechanisms of TP have never been reported.
View Article and Find Full Text PDF