Hydrothermally Constructed MoS2/ZnIn2S4 Heterostructure for Promotion of Photocatalytic H2 Evolution.

The integration of the second material with unique properties into original material to fabricate heterostructure represents an effective strategy to enhance photocatalytic H2 evolution. Herein, we synthesized a MoS2/ZnIn2S4 heterostructured photocatalyst using a two-step hydrothermal method. The resulting MoS2/ZnIn2S4 displayed the flower-like morphology formed by staked nanosheets, significantly accelerating photocatalytic H2 evolution performance.

Top 100 Most-Cited Articles on Difficult Airway Management From 2011 to 2022: A Bibliometric Analysis.

Background: Difficult airway management (DAM) presents a complex array of challenges inherent in establishing and maintaining a patient's airway during medical procedures or emergencies. Consequences of compromised DAM are profound, ranging from hypoxia, and aspiration, to cardiac arrest. Despite the ongoing progress and innovation in airway management, DAM remains a significant clinical challenge.

Advances in the study of the role of high-frequency mutant subunits of the SWI/SNF complex in tumors.

SWI/SNF (Switch/Sucrose non-fermentable, switch/sucrose non-fermentable) chromatin remodeling complex is a macromolecular complex composed of multiple subunits. It can use the energy generated by the hydrolysis of ATP (Adenosine triphosphate) to destroy the connection between DNA and histones, achieve the breakdown of nucleosomes, and regulate gene expression. SWI/SNF complex is essential for cell proliferation and differentiation, and the abnormal function of its subunits is closely related to tumorigenesis.

Deubiquitinases as novel therapeutic targets for diseases.

Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately 100 DUBs in humans counteract E3 ubiquitin ligases, finely balancing ubiquitination and deubiquitination processes to maintain cellular proteostasis and respond to various stimuli and stresses. Given their role in modulating ubiquitination levels of various substrates, DUBs are increasingly linked to human health and disease.

Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion.

Lumbar spinal fusion is a common procedure for treating spinal degenerative diseases. Percutaneous endoscopic lumbar interbody fusion (PELIF) is a minimally invasive technique that has gained popularity. However, the factors influencing fusion success rates after PELIF have not been well-studied.

Stereoselective chemical N-glycoconjugation of amines via CO incorporation.

Chemical N-glycoconjugation can provide a unique way to tailor the properties of the ubiquitous amines for further expending their diverse functions and applications. Nevertheless, effective methodology for glycoconjugation of amines remains largely underdeveloped. Inspired by a biotransformation pathway of amine-containing drugs in vivo, we have developed an effective protocol that enables one-step chemical N-glycoconjugation of amines in high stereoselectivity under mild conditions.

Enzymatic Oxidation of Aflatoxin M in Milk Using CotA Laccase.

Aflatoxin M (AFM) in milk poses a significant threat to human health. This study examined the capacity of CotA laccase to oxidize AFM. The optimal conditions for the CotA laccase-catalyzed AFM oxidation were observed at pH 8.

Enhancing the timeliness of EMR documentation in resident doctors: the role of PDCA cycle management.

Background: The impact of the Plan-Do-Check-Act (PDCA) cycle in improving the timeliness of electronic medical record documentation (EMRd) remains uncertain. EMRd that is completed beyond the specified time is classified as late EMRd, while unqualified EMRd refers to electronic medical records with important sections that are not completed on time according to the Chinese Basic Norms of Medical Records Writing. This study aimed to evaluate the effectiveness of PDCA management in improving the timeliness of EMRd among resident doctors.

Late-stage-functionalization of anti-depressant molecule buspirone.

Buspirone, a well-established anxiolytic agent, has gained attention for its potential role as an antidepressant, primarily due to its unique pharmacological profile and the ability to modulate serotonin receptors effectively. Late-stage functionalization is considered as a pivotal strategy in drug synthesis that enhances the therapeutic efficacy of existing molecules. This review summarizes various late-stage functionalization techniques applicable to Buspirone, including photocatalyzed, metal-catalyzed, and enzyme-catalyzed reactions.

Unraveling Plant Nuclear Envelope Composition Using Proximity Labeling Proteomics.

The nuclear envelope (NE) defines the eukaryotic cell and functions in a myriad of fundamental cellular processes including but not limited to signal transduction, lipid metabolism, chromatin organization, and nucleocytoplasmic transportation. Although the general structure of the NE is well-conserved across eukaryotic kingdoms, its composition and functions vary substantially between species and remain largely unknown in plants. In this chapter, we describe a proximity-labeling-based proteomic approach to profile novel NE components in the model organism Arabidopsis.

Mechanics-Photophysics Correlation in Tough, Stretchable and Long-Lived Room Temperature Phosphorescence Ionogels Deciphered by Dynamic Mechanical Analysis.

The development of tough, stretchable and long-lived room temperature phosphorescence (RTP) materials holds great significance for manufacturing and processing photoluminescent materials, but limited techniques are available to profile their mechanics-photophysics correlation. Here we report glassy ionogels, and their mechanical properties and photophysical properties are fused by dynamic mechanical analysis (DMA), functioning like a human brain that perceives a material instantaneously by linking sensory perception and cognition. Depending on two special temperatures presented in DMA curves, T (the peak of loss modulus (E")) and T (glass transition temperature), the ionogels can vary from being either tough with persistent phosphorescence, extensible with effective phosphorescence or resilience with inefficient phosphorescence.

Wearable Sensor Based on Covalent Organic Framework Humidity Films for Long-Term Monitoring of Tomato Physiology Under Abiotic Stress.

Global agricultural productivity is affected by plant stresses every year; as a consequence, monitoring and preventing plant stresses is a significant measure to protect the agro-ecological environment. Similar to the adoption of wearable devices to appraise human physiological information and disease diagnosis, however, in situ nondestructive monitoring of complex and weak physiological information in plants is an enormous challenge for the development of wearable sensors. Herein, to accurately analyze the changes of tomato internal information under multiple abiotic stresses in real-time, we introduce the covalent organic framework (COF) film synthesized by self-assembly layer by layer through the oil/water interface as a sensitive material to develop a multifilm-integrated wearable sensor capable of monitoring leaf surface humidity and leaf temperature.

Comprehensive geriatric assessment guided radiotherapy in elderly patients with locally advanced rectal cancer-exploratory results on nonoperative cohort of a multicenter prospective study.

Background: Chemoradiotherapy (CRT) is the main treatment for elderly patients with non-metastatic rectal cancer who are ineligible for or decline surgery, but the optimal modality remains unclear.

Objectives: This study was to validate the safety and efficacy of comprehensive geriatric assessment (CGA) guided radiotherapy in older patients.

Design: An exploratory analysis of a single-arm, multicenter, Phase II trial.

Turning on Low-Temperature Catalytic Conversion of Biomass Derivatives through Teaming Pd and Mo Single-Atom Sites.

On-purpose atomic scale design of catalytic sites, specifically active and selective at low temperature for a target reaction, is a key challenge. Here, we report teamed Pd and Mo single-atom sites that exhibit high activity and selectivity for anisole hydrodeoxygenation to benzene at low temperatures, 100-150 °C, where a Pd metal nanoparticle catalyst or a MoO nanoparticle catalyst is individually inactive. The catalysts built from Pd or Mo single-atom sites alone are much less effective, although the catalyst with Pd sites shows some activity but low selectivity.

Two distinct clinical progressions of P67phox-deficient CGD, both commencing with cervical lymphadenitis.

We present two rare cases of p67phox-deficient chronic granulomatous disease (CGD) caused by compound heterozygous mutations in the NCF2 gene. They developed cervical lymphadenitis as the initial manifestation of CGD but had distinct clinical progressions. Patient 1 presented with aspergillous meningitis, an extremely rare manifestation of neurological involvement in CGD, which has not been reported before.

Targeting the HECTD3-p62 axis increases the radiosensitivity of triple negative breast cancer cells.

Triple negative breast cancer is the most malignant subtype of breast cancer and current treatment options are limited. Radiotherapy is one of the primary therapeutic options for patients with TNBC. In this study, we discovered that the E3 ubiquitin ligase, HECTD3, promoted TNBC cell survival after irradiation.

[Effect and Influencing Factors of Peripheral Blood Hematopoietic Stem Cells Collection from Unrelated Donors].

Objective: To analyze the effect of peripheral blood hematopoietic stem cells (PBSC) collection from unrelated donors and its influencing factors.

Methods: A retrospective analysis was conducted on the mobilization and collection of PBSC from 113 unrelated donors at Yueyang Central Hospital from January 2021 to December 2023.

Results: 113 donors were successfully mobilized.

Enantiomorphic Site-Assisted Chain End Control Stereospecific Alternating Copolymerization of Chiral Cyclic Diesters.

Stereospecific alternating copolymerization of different chiral cyclic esters is one feasible approach to enrich the structural diversity of copolyesters and tailor their properties. However, dramatically different reactivities of different cyclic esters let a perfectly stereospecific alternating polymerization of these cyclic esters be a challenge, thus the catalyst is required to balance their reactivities. Herein, a remarkable enantiomorphic site effect on chain end control was discovered and successfully utilized to balance the reactivities of highly reactive S, S-lactide (S, S-LA) and low reactive R, R-ethylglycolide (R, R-EG)/R, R-propylglycolide (R, R-PG) during their heterospecific alternating copolymerization.

Beyond clinical trials: CDK4/6 inhibitor efficacy predictors and nomogram model from real-world evidence in metastatic breast cancer.

Background: CDK4/6 inhibitors (CDK4/6i) have shown promising results in the treatment of hormone receptor-positive (HR+) metastatic breast cancer (MBC) when combined with endocrine therapy (ET). It is crucial to evaluate the actual effectiveness and safety of CDK4/6i in clinical practice, as well as to analyze the factors that can predict their outcomes.

Methods: Patients with HR+ MBC who received CDK4/6i-based therapy between May 2016 and May 2023 at Hunan Cancer Hospital were evaluated for progression-free survival (PFS).

Rutin distribution in Tartary buckwheat: Identifying prime dietary sources through comparative analysis of post-processing treatments.

Rutin is a crucial bioactive compound that determines the nutritional value of Tartary buckwheat (TB). However, the potential of utilizing TB as a dietary source of rutin for human consumption remains largely unexplored. This study aims to address these knowledge gaps by conducting a detailed analysis of rutin content distribution in TB tissues.

Evaluation of the effect of orthodontic treatment on the reliability of facial recognition by using three-dimensional model superimposition technique.

3D-3D registration of facial models, has great advantages in personal individual identification in forensic medicine. However, orthodontic treatment has brought changes in facial soft and hard tissues, which has a potential effect in personal identification. The aim of the study was to explore whether orthodontic treatment affects 3D-3D facial recognition.