Publications by authors named "Tang Xiaomin"
Article Synopsis
- Cervical cancer is a prevalent type of cancer affecting women's reproductive systems, especially in developing nations, but skin metastasis from it is rare.
- The study discusses a case of a 44-year-old woman with stage IIA gastric-type endocervical adenocarcinoma.
- After treatment involving a radical hysterectomy and chemoradiation, the patient developed skin metastasis in the vulvar area two years later.
Purpose: To evaluate the therapeutic effect of oral administration of P101 (P101) on skeletal injury in young rats exposed to titanium dioxide nanoparticles (TiO NPs), and explore the potential mechanism.
Methods: Four-week-old male rats were orally administration to TiO NPs and supplemented with P101 2 hours later for 4 weeks. The growth and development, food intake, bone metabolism and serum inflammatory markers of the rats were evaluated.
Article Synopsis
- Enterovirus A71 (EVA71) is a major cause of hand, foot, and mouth disease in young children, especially in Asia-Pacific, and there's currently no specific treatment for it, making quick diagnosis vital.
- A new detection method combining reverse transcription-multiple cross displacement amplification (RT-MCDA) and nanoparticle-based lateral flow biosensors (LFB) was developed, allowing for fast and visual identification of EVA71 without specialized equipment.
- This new assay is highly sensitive, needing less than an hour to complete the entire process, and showed effective results in clinical tests with a high degree of accuracy compared to standard methods, making it suitable for use in basic medical settings.
The biomass of Isodon rubescens stems is greater than that of the leaves. The stems possess a considerable surface area, although less than that of the leaves. The photosynthetic rates, light response curves and chlorophyll fluorescence characteristics of the stems were determined in this study to clarify their photosynthetic capacity and photosynthetic potential.
View Article and Find Full Text PDFCopper-based nanomaterials have the properties of mimetic enzymes and can be used as excellent candidates for colorimetric sensing due to their environmental friendliness, low cost, and high abundance. In this paper, Ni-doped CuO nano cauliflower (Ni-CuO) was synthesized for the first time and applied to the detection of HO and uric acid (UA) in human serum and urine. It was found that the proportion of Ni incorporation controls the morphology and the catalytic effect of Ni-CuO.
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- The purification of cyclohexane is crucial for producing various materials but is difficult due to its similarities with benzene.
- This research showcases a specific zeolite (SSZ-74) that achieves high productivity in separating cyclohexane from benzene, producing ultrapure cyclohexane with very low benzene content.
- The study combines various advanced techniques, such as DFT calculations and FTIR spectroscopy, to explain how the unique structure of the zeolite enhances its separation capabilities.
Article Synopsis
- * A new adsorbent derived from flocculation sludge (FSD) displayed a remarkable removal rate of methylene blue dye at 96.48%, thanks to its unique structure and functional properties.
- * The FSD adsorbent is effective even after multiple uses, maintaining a removal rate above 71.8% and demonstrating low dye leaching, indicating its potential for practical applications in wastewater treatment.
Article Synopsis
- The study investigated the levels of oridonin in ice ribbons and bleeding sap from Isodon rubescens over time using High-Performance Liquid Chromatography (RP-HPLC).
- Results indicated that oridonin concentration was higher in the stem compared to the ice ribbons and decreased over TIME, while its content in bleeding sap was similar to that in ice ribbons by day two.
- The research highlighted that water in ice ribbons comes from soil absorption by roots and is effectively transported through the plant's vascular system, with oridonin dissolving in this water and forming ice below 0 °C.
Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to investigate the role of RNA-binding motif protein 15 (RBM15) in the cisplatin (DDP) resistance of LC cells. LC-DDP-resistant cells were constructed.
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- A new portable swab that connects to smartphones has been developed to measure glucose (Glu) levels in food, which is crucial for diabetics.
- The swab uses a combination of natural enzymes and nanozymes to efficiently detect Glu through a color change and fluorescence, making it easy to read the results.
- Testing showed that this dual-mode detection method is effective for guiding diabetics in managing their glucose intake accurately.
Article Synopsis
- * These flocculants are notable for their effectiveness in removing both traditional and new pollutants from wastewater, thanks to their unique structures and abundant functional groups.
- * The review addresses both the benefits, like safety and renewability, and the challenges of using bio-based flocculants, suggesting strategies for improvement in their practical applications.
Article Synopsis
- F-53B, a type of PFAS widely used in industry, is known to harm various organs but its effects on bone health have not been studied until now.
- This research focused on how maternal exposure to F-53B during pregnancy affects the bone growth and development of mouse offspring.
- Findings revealed that F-53B exposure leads to impaired bone growth, osteoporosis, and disruption of key bone metabolism processes in male offspring, potentially through the IGF-1 signaling pathway.
Article Synopsis
- * Through cloning and transgenic techniques involving Agrobacterium tumefaciens, researchers created a transgenic line to assess growth and physiological traits.
- * Results indicated that the transgenic plants exhibited faster growth, advanced flowering and fruiting, and changes in biochemical markers, linking the transcription factor's expression to these beneficial traits.
Article Synopsis
- Single-atom catalysts (SACs) are gaining attention for their high efficiency and resource use, yet creating multi-functional single-atom nanozymes for biosensors still poses challenges.
- This research successfully developed a composite material, iron-doped carbon dots (Fe CDs) combined with Mo SACs, enhancing catalytic performance without altering the existing structure.
- The new dual-mode sensor created can accurately detect hydrogen peroxide and uric acid, demonstrating effective sensitivity in human serum and urine samples while advancing the application of SACs in biosensing technology.
Article Synopsis
- - The study investigates the harmful effects of microplastics (MPs) on young rats' bone development, revealing that exposure to MPs led to decreased growth, shorter bone length, and altered calcium and phosphorus levels.
- - Using various methods, including administering ER stress inhibitors and agonists, researchers found that MPs induced significant changes in the growth plate structure and increased the expression of genes associated with ER stress, which negatively impacted chondrocyte health.
- - The findings suggest that microplastics can cause growth retardation and bone damage in developing organisms, primarily through mechanisms related to endoplasmic reticulum stress and disrupted bone formation processes.
Article Synopsis
- The study compares enzyme methods (using a CaF/MnO nanocomposite with dual activity) and nonenzyme methods for detecting uric acid (UA) in human serum, highlighting a long-standing debate in nanosensing.
- The enzyme method uses uricase to produce reactive oxygen species (ROS) that oxidize a dye, while the nonenzyme method relies on UA's scavenging effect on ROS to measure UA levels.
- Results show that the enzyme method offers better selectivity, and both methods effectively determine UA concentration, potentially improving detection accuracy when used together and supporting future design of nanozyme catalysts for biochemical applications.
Article Synopsis
- * Research showed that KCNMA1 levels decrease in older mice, while indicators of ferroptosis (a type of cell death) increase.
- * Lowering KCNMA1 levels in hearing cells sped up aging and increased ferroptosis, indicating KCNMA1's role in aging and hearing loss.
To further explore the mechanism of "the longer storage time, the better bioactivity" of aged Guang Chenpi, the dry pericarp of 'Chachi' (CRC), a series of activity assessments were performed on spleen deficiency mice. The constituents in CRC with different storage years were analyzed by LC-Q-Orbitrap/MS. A total of 53 compounds were identified, and CRC stored for more than 5 years showed higher flavonoid content, especially that of polymethoxyflavones.
View Article and Find Full Text PDFJingmen virus (JMV) associated with ticks and vertebrates have been found to be related to human disease. We obtained the genome of a Jingmen tick virus (JMTV) strain from Rhipicephalus microplus in Guizhou province and compared the genomes of seven JMV species associated with ticks and vertebrates to understand the evolutionary relationships. The topology of the phylogenetic tree of segment 1 and segment 3 is similar, and segment 2 and segment 4 formed two different topologies, with the main differences being between Alongshan virus (ALSV), Takachi virus, Yanggou tick virus and Pteropus lylei jingmen virus (PLJV), and the possibility of genetic reassortment among these viruses.
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- * The study involved collecting female mosquitoes and analyzing them using cell cultures, RT-PCR, and next-generation sequencing to identify and characterize the QBV.
- * Results showed the presence of QBV RNA in mosquitoes from Guizhou Province, China, and highlighted genetic similarities and variations among different QBV isolates from Vietnam and China.
Article Synopsis
- Abl is a nonreceptor tyrosine kinase that plays a role in various diseases, including rheumatic immune disorders, and contains specific domains for binding to proteins.* -
- Researchers used a synthetic proline-rich peptide called p41 and modified it by changing certain residues to enhance its binding affinity to Abl's SH3 domain.* -
- Several new peptoid variants showed significantly improved binding strength to the Abl SH3 domain and demonstrated a high selectivity for Abl compared to other tyrosine kinases.*
Article Synopsis
- Single-atom catalysts (SACs) are gaining attention for their high catalytic activity, but enhancing the atomic loading of metal atoms remains a challenge.
- * The study introduces a new type of catalyst called iron and molybdenum co-doped dual single-atom catalysts (Fe/Mo DSACs), which showed improved atomic loading and strong oxidase-like and peroxidase-like activities.
- * These Fe/Mo DSACs can effectively catalyze reactions that lead to a visible color change in a solution, providing a sensitive detection method for hydrogen peroxide and uric acid with significant improvements in catalytic efficiency compared to individual metal SACs.
Article Synopsis
- Obesity is a major public health concern linked to heart problems, particularly subclinical myocardial injury, which increases heart failure risk; this study investigates mechanisms behind this issue.
- Mice were fed a high-fat diet to create an obesity model, and researchers measured various health indicators and assessed inflammation and macrophage behavior related to heart injury.
- The study found that reducing LEAP-2 levels improved heart health in obese mice by reducing inflammation and promoting a beneficial macrophage type (M2), suggesting that targeting LEAP-2 might be a strategy to mitigate obesity-related heart damage.
Article Synopsis
- The study examines how the ageing process of sorghum vinegar affects its toxicity and biological activity, focusing on intermediate Maillard reaction products and their hepatoprotective effects.
- Using techniques like HPLC and fluorescence spectrophotometry, researchers found significant increases in harmful compounds during the vinegar's 18-month ageing.
- The results suggest that pure melanoidin from vinegar can protect against liver damage in rats, indicating a need for shorter ageing times to ensure safety and highlight melanoidin's potential in preventing liver oxidative stress.
Article Synopsis
- Plastics are crucial for society due to their lightweight and low-cost nature, with over 400 million metric tons produced annually, but their diverse chemical structures complicate effective reuse and recycling, leading to significant waste management challenges.
- Current recycling methods largely succeed with single-type plastics, but mixed plastic waste requires extra sorting, prompting researchers to develop advanced technologies like selective deconstruction catalysts to improve recycling processes.
- Collaborating academic and industrial efforts can enhance recycling systems, establish closed-loop circularity for plastics, and contribute to achieving a net zero carbon society by reducing environmental impacts.