[Sorption and Transport of Antibiotics in Manured Upland Agricultural Soils].

Sorption and transport are important environmental behaviors of antibiotics in soils and can determine the fate of antibiotics in environments； however, limited relevant studies have been conducted on long-term manured soils. In this study, batch and repacked soil column experiments were conducted to examine the sorption and transport behavior of four veterinary antibiotics, including sulfamethazine （SMT）, florfenicol （FFC）, doxycycline （DOX）, and enrofloxacin （ENR）, in red soils, yellow soils, and calcareous soils with long-term amendment of chicken or pig manure collected in Zhejiang Province. The results showed that the sorption isothermal data of the four target antibiotics all conformed well to the linear and Freundlich models.

Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy.

Tumor-initiating cells (TICs) possess the ability to evade anti-tumor immunity, potentially explaining many failures of cancer immunotherapy. Here, we identify CD49f as a prominent marker for discerning TICs in hepatocellular carcinoma (HCC), outperforming other commonly used TIC markers. CD49f-high TICs specifically recruit tumor-promoting neutrophils via the CXCL2-CXCR2 axis and create an immunosuppressive milieu in the tumor microenvironment (TME).

Balancing river water pollution and agricultural development: A tradeoff threshold approach.

Balancing environmental protection and social-economic development in agricultural land use management is a dilemma for decision-makers. Based on the modelling of the impacts of land use changes on river water pollution by SWAT model, the tradeoff between tea plantation expansion and river water quality was detected. SWAT model performs well in simulating the non-point source (NPS) pollution in agricultural watershed.

Size and polarity fractions of mobile organic matter from manure affect the sorption of sulfadiazine, caffeine and atenolol in soil.

Waste-derived organics introduced to soils along with pharmaceutical active compounds (PhAC) are a crude mixture of compounds occurring in various size and polarity fractions. They affect the sorption of PhACs to soil; however, the relevant knowledge is still insufficient. The effects of different size and polarity fractions of manure-derived mobile organic matter (<63 µm) on the sorption of sulfadiazine, caffeine and atenolol to five topsoils were investigated.

Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.

Neural stem cells (NSCs) exhibit a remarkable capacity for self-renewal and have the potential to differentiate into various neural lineage cells, which makes them pivotal in the management of neurological disorders. Harnessing the inherent potential of endogenous NSCs for enhancing nerve repair and regeneration represents an optimal approach to addressing diseases of the nervous system. In this study, we explored the potential of a novel benzophenone derivative named Digirseophene A (DGA), which was isolated from the endophytic fungus Corydalis tomentella.

Spatial heterogeneity of the effects of river network patterns on water quality in highly urbanized city.

River water quality deterioration is a serious problem in urban water environments. River network patterns affect water quality by influencing the flow, mixing, and other processes of water bodies. However, the effects of urban river network patterns on water quality remain poorly understood, thereby hindering the urban planning and management decision-making process.

A Novel Leverage Technique Using Monoaxial Pedicle Screw for Reduction of Thoracolumbar Compression Fractures: Surgical Technique and Analysis of Radiological Parameters.

Objective: Thoracolumbar compression fractures resulting from high-energy injuries are a common type of spinal fracture. Satisfying reduction of compressive vertebra body is essential for the clinical outcome. However, traditional distraction technique may lead to complications including pedicle screw loosening, pedicle screw breakage, and postoperative back pain because of excessive distraction.

Evaluation of Left Ventricular Flow Kinetic Energy by Four-Dimensional Blood Flow MRI in Nondialysis Chronic Kidney Disease Patients.

Background: Chronic kidney disease (CKD) is associated with increased, and early cardiovascular disease risk. Changes in hemodynamics within the left ventricle (LV) respond to cardiac remodeling. The LV hemodynamics in nondialysis CKD patients are not clearly understood.

Biochar reduces antibiotic transport by altering soil hydrology and enhancing antibiotic sorption.

The performance of biochar (BC) in reducing the transport of antibiotics under field conditions has not been sufficiently explored. In repacked sloping boxes of a calcareous soil, the effects of different BC treatments on the discharge of three relatively weakly sorbing antibiotics (sulfadiazine, sulfamethazine, and florfenicol) via runoff and drainage were monitored for three natural rain events. Surface application of 1 % BC (1 %BC-SA) led to the most effective reduction in runoff discharge of the two sulfonamide antibiotics, which can be partly ascribed to the enhanced water infiltration.

Research trend of MRI application for lumbar disc degeneration with low back pain: a bibliometric analysis.

Background: Low Back Pain (LBP) is a pervasive and complex musculoskeletal condition affecting over 80% of the global population. Lumbar Disc Degeneration (LDD) significantly contributes to LBP, and MRI is crucial for its diagnosis and understanding. This study aimes to provide a comprehensive bibliometric analysis of MRI research on LDD with LBP, shedding light on research patterns, collaborations, and potential knowledge gaps.

Feasibility of diffusion tensor imaging in cervical spondylotic myelopathy using MUSE sequence.

Background Context: The most frequent type of spinal cord injury is cervical spondylotic myelopathy (CSM). Conventional structural magnetic resonance imaging (MRI) is the gold diagnosis standard for CSM. Diffusion tensor imaging (DTI) could reflect microstructural changes in the spinal cord by tracing water molecular diffusion in early stages of CSM.

The Effect of Empagliflozin on Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway in Patients with Type 2 Cardiorenal Syndrome.

Background: Empagliflozin (EMPA) demonstrates cardioprotective effects on the patients with heart failure, but its effects in cardiorenal syndrome (CRS) remain unspecified. The purpose of the exploratory study was to investigate the effect of EMPA on patients with type 2 CRS and type 2 diabetes mellitus (DM).

Methods: This study was a randomized trial of patients with type 2 CRS and DM done between December 2020 and January 2022.

Control of the annular spatial profile of high harmonics using a Bessel-Gaussian beam carrying the nonzero orbital angular momentum.

We propose to generate vortex high harmonics in the extreme ultraviolet (XUV) with a controllable spatial profile by using a Bessel-Gaussian (BG) beam carrying a nonzero orbital angular momentum (OAM). Such BG beam has quite a different intensity profile at the focus compared to the generally used BG beam without carrying the OAM. We show that the BG beam is capable of generating single-ring structured high harmonics, which is quite different from an Laguerre-Gaussian (LG) beam with a similar intensity distribution at the laser focus.

Effect of urbanization and urban forests on water quality improvement in the Yangtze River Delta: A case study in Hangzhou, China.

In the context of rapid global urbanization, the sustainable development of ecosystems should be considered. Accordingly, the Planetary Boundaries theory posits that reducing the amount of nitrogen and phosphorus pollutants entering bodies of water is necessary as excess levels may harm the aquatic environment and reduce in water quality. Thus, based on the long-term monitoring data of representative urban rivers in the Yangtze River Delta region, we evaluated the nitrogen and phosphorus pollution of water bodies in different urbanization stages and further quantified the effect of urban forests on water quality improvement.

Controlling laser-dressed resonance line shape using attosecond extreme-ultraviolet pulse with a spectral minimum.

High-harmonic generation from a gas target exhibits sharp spectral features and rapid phase variation near the Cooper minimum. By applying spectral filtering, shaped isolated attosecond pulses can be generated where the pulse is split into two in the time domain. Using such shaped extreme-ultraviolet (XUV) pulses, we theoretically study attosecond transient absorption (ATA) spectra of helium [Formula: see text] autoionizing state which is resonantly coupled to the [Formula: see text] dark state by a time-delayed infrared laser.

[Characteristics of Antibiotic Resistance Genes Distribution in Different Types of Agricultural Land Soils in Highly Cultivated Hilly Areas].

To characterize the distribution of antibiotic resistance genes(ARGs) in different types of agricultural soil in highly cultivated hilly areas, the abundance and diversity of ARGs in vegetable, orchard, and arable soils were analyzed in this study. The results showed that 70 ARGs and four mobile genetic elements(MGEs) were detected in all soil samples, with -lactam being the most abundant genes in the agricultural soils. In vegetable and orchard soils, the main ARG subtypes were and () genes, whereas the and genes were predominant in cropland soils.

Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer.

Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in GC targeted therapies has occurred. Synthetic lethality refers to the concept that simultaneous dysfunction of a pair of genes results in a lethal effect on cells, while the loss of an individual gene does not cause this effect. Through exploiting synthetic lethality, novel targeted therapies can be developed for the individualized treatment of GC.

A novel tool for tracing water sources of streamflow in a mixed land-use catchment.

Tracing water sources of streamflow in a mixed land-use catchment is critical for predicting pollutant emissions from various human activities to streams but remains a major challenge. A rain event based field monitoring study was conducted in the Jieliu catchment located in the hilly area of central Sichuan Province, southwest China. The ratio of the maximum fluorescence intensities (F) of the two humic-like dissolved organic matter (DOM) components at excitation/emission wavelengths of 255 (315)/415 nm (component 1; C1) and 260 (375)/480 nm (component 2; C2) was proposed as a tracer for quantifying streamflow water sources.

[Effect of Manure Application on the Adsorption of Antibiotics to Soil].

Sulfonamide antibiotics and florfenicol(FFC) are commonly used antibiotics in Zhejiang Province. They have weak adsorption on soil and are easy to migrate, with high environmental risks. In recent years, most of the studies on the potential risk of fecal-derived antibiotics to farmland soil were conducted by adding manure under laboratory conditions; therefore, it is impossible to assess the risk of antibiotic pollution under natural fertilization.

In Different Gender Groups, What Is the Impact of the Fibular Notch on the Severity of High Ankle Sprain: A Retrospective Study of 360 Cases.

Objectives: The role of the distal tibiofibular ligament in the occurrence of high ankle sprain (HAS) has been widely studied. But previous studies have overlooked the physiological and anatomical differences between males and females and have not further refined gender. Therefore, the impact of the anatomical morphology of fibular notch (FN) on HAS in different genders is still unclear.

Role of the Porras factor in phase matching of high-order harmonic generation driven by focused few-cycle laser pulses.

We investigate the role of the Porras factor (or laser focusing effect) on the macroscopic high-order harmonic generation (HHG) driven by a focused broadband few-cycle laser beam. By employing a non-adiabatic phase-matching analysis method, we reveal that phase mismatch due to the induced-dipole phase varies with the Porras factor, which is dominant in phase matching at low gas pressure. We also find that in a strongly ionized medium when gas pressure is high, the nonlinear propagation is dominated by a plasma effect such that the focusing effect is mitigated, resulting in similar poor phase matching of HHG regardless of the Porras factor.

Co-assembly of stearoylated cellulose nanocrystals and GO (or CNTs) for the construction of superhydrophobic hierarchical structure with enhanced photothermal conversion.

The development of photothermal materials with high photothermal-conversion efficiencies is important in a range of applications, such as power generation, sterilization, desalination, and energy-production. To date, a few reports have been published related to improving the photothermal conversion performances of photothermal materials based on self-assembled nanolamellae. Herein, hybrid films of co-assembled stearoylated cellulose nanocrystals (SCNCs) and polymer-grafted graphene oxide (pGO)/polymer-grafted carbon nanotubes (pCNTs) were prepared.

Quantitative evaluation of the spinal cord compression in patients with cervical spondylotic myelopathy using synthetic MRI.

This work aimed to investigate the feasibility and diagnostic value of synthetic MRI, including T1, T2 and PD values in determining the severity of cervical spondylotic myelopathy (CSM). All subjects (51 CSM patients and 9 healthy controls) underwent synthetic MRI scan on a 3.0T GE MR scanner.

Initial soil moisture conditions affect the responses of colloid mobilisation and associated cadmium transport in opposite directions.

The effects of initial soil moisture on colloid-associated transport are still poorly understood given the well-recognized significance of colloid-facilitated transport of strongly-sorbing contaminants. In this study, Cd leaching was sequentially conducted in an intact soil column under three initial moisture conditions (near saturation, field capacity and dryness). Soil colloids were always the dominant carriers for Cd.

Role of fractional high harmonics with non-integer OAM on the generation of a helical attosecond pulse train.

Extreme-ultraviolet pulses of attosecond duration carrying orbital angular momentum (OAM) can be produced by spectrally filtering vortex high harmonics generated in a gas medium. Here we reveal that fractional high harmonics (FHHs) with non-integer OAM generated by a short duration Laguerre-Gaussian laser beam are origins for the change of helical attosecond pulse train (APT) with azimuthal angle. We show that these harmonics have gap and minimum structures in the annular intensity profile and discontinue phase distribution along azimuthal angle.