Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancers.

Background: Cancer remains one of the most significant public health challenges worldwide. A widely recognized hallmark of cancer is the ability to sustain proliferative signaling, which is closely tied to various cell cycle processes. Centromere Protein A (CENPA), a variant of the standard histone H3, is crucial for selective chromosome segregation during the cell cycle.

Association between hormone therapy and glioma risk in US women: a cancer screening trial.

Objective: Gliomas are the most common primary brain tumors in adults, and the role of hormone therapy (HT) in their development remains controversial. This study with a cohort design aimed to investigate the association between HT use and glioma risk using the data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

Methods: We analyzed data from 75,335 women, aged 50-78, who were enrolled between 1993 and 2001.

Ocular biometric parameters in Chinese preschool children and physiological axial length growth prediction using machine learning algorithms: a retrospective cross-sectional study.

Objectives: To examine the ocular biometric parameters and predict the annual growth rate of the physiological axial length (AL) in Chinese preschool children aged 4-6 years old.

Methods: This retrospective cross-sectional study included 1090 kindergarten students (1090 right eyes) between the ages of 4 and 6 years from Pinggu and Chaoyang District, Beijing. Dioptre values were ascertained following cycloplegic autorefraction.

High-performance amino-crosslinked phosphorylated microcrystalline cellulose/MoS hybrid aerogel for polystyrene nanoplastics removal from aqueous environments.

Currently, the development of high-performance adsorbents for the removal of nanoplastics in complex aquatic environments is challenging. In this study, a functionalized polyethyleneimine-phosphorylated microcrystalline cellulose/MoS (PEI-PMCC/MoS) hybrid aerogel was prepared and applied to remove carboxyl-modified polystyrene (PS-COOH) nanoplastics from the aqueous solution. Benefiting from the introduced functional groups and the expanded lamellar structure in MoS nanosheets as well as the highly porous 3D structure of the aerogel, PEI-PMCC/MoS demonstrated high efficiency in PS-COOH nanoplastics removal, achieving a 402.

Association between daily sitting time and sarcopenia in the US population: a cross-sectional study.

Background: Sarcopenia is an age-related syndrome marked by a gradual decline in skeletal muscle mass and function. While various factors influencing sarcopenia have been studied, the link between daily sedentary time and sarcopenia remains underexplored.

Method: This study analyzed the association between daily sitting time and sarcopenia using data from the National Health and Nutrition Examination Survey (NHANES 2011-2018).

Xuefu Zhuyu Decoction Improves Blood-Brain Barrier Integrity in Acute Traumatic Brain Injury Rats via Regulating Adenosine.

Objective: To explore the neuroprotective effects of Xuefu Zhuyu Decoction (XFZYD) based on in vivo and metabolomics experiments.

Methods: Traumatic brain injury (TBI) was induced via a controlled cortical impact (CCI) method. Thirty rats were randomly divided into 3 groups (10 for each): sham, CCI and XFZYD groups (9 g/kg).

Successful thoracoscopic-assisted resection of a functional paraganglioma in the mediastinum with extracorporeal circulation: a case report.

Background: Paragangliomas are rare neoplasms arising from extra-adrenal chromaffin cells, with mediastinal paragangliomas representing an exceptionally rare subset. This report details the surgical management of a complex mediastinal paraganglioma case, presenting with refractory hypertension and invasion of critical surrounding structures. A comprehensive review of the current literature is included to underscore existing cases, enhance clinical awareness, and share our insights and experience in the diagnosis and treatment of this challenging condition.

An efficient co-culture of and for phenol degradation under high salt conditions.

Phenol is one of the major organic pollutants in high salt industrial wastewater. The biological treatment method is considered to be a cost-effective and eco-friendly method, in which the co-culture of microalgae and bacteria shows a number of advantages. In the previous study, a co-culture system featuring () and () was established and could degrade 400 mg L phenol at 3% NaCl concentration.

The structure impact of lignin in pulping material on the energy storage performance of black liquor derived carbon cathodes for zinc ion hybrid capacitors.

Cooking black liquors generated during the pulping process have been recognized as promising electrode materials which can be directly applied as carbon sources. This paper investigates the relationship between the microstructure of lignin and the electrochemical properties of carbon derived from black liquor obtained from various plants, including softwood, hardwood, and grass. It was found that eucalyptus black liquor, abundant in methoxy groups, has a notable impact on the performance of carbon materials compared to black liquor derived from Pinus sylvestris and bamboo.

Combined effects of different-sized microplastics and fluindapyr on earthworm: bioaccumulation, oxidative stress, histopathological responses and gut microbiota.

Soil is an important sink for microplastics (MPs) and pesticides. MPs can act as carriers for pesticides, thus induce direct and indirect effects on soil organisms. Fluindapyr (FIP), a novel succinate dehydrogenase inhibitors fungicides (SDHIs), may pose a serious threat to earthworms.

Biodegradable sodium lignosulfonate-based superabsorbent hydrogels for disposable hygiene products based on hyperbranched polyetherpolyol crosslinkers.

Full bio-degradation of super absorbent hydrogels (SAHs), which possess excellent water uptake capacity, is still challenging. Based on Flory theory, this paper first analyzes that the high swelling property and gel strength of SHAs are attributed to the length of effective chain of crosslinker. Firstly, a series of hyperbranched crosslinker (HBC) with different molecular weights were designed and synthesized by anionic polymerization and sodium lignosulfonate (SL), which owns a hydrophilic network and remarkable biodegradation properties, was selected as a monomer.

Corneal elevation asymmetry vector: Viable predictor of severe one-year-averaged orthokeratology lens decentration.

Background: To assess the predictive value of pretreatment corneal elevation asymmetry vector (CEAV) for severe orthokeratology (Ortho-k) lens decentration (LD) in Chinese myopic adolescents.

Methods: A retrospective analysis of 247 myopic participants over one year employed a novel MATLAB algorithm to calculate CEAV and precise LD vector. Subjects were categorized into mild (<1 mm) and severe (≥1 mm) yearly averaged LD (YALD) groups.

Neuroprotective Potential of Glycyrrhizic Acid in Ischemic Stroke: Mechanisms and Therapeutic Prospects.

Ischemic stroke is a leading cause of disability and mortality worldwide, with current therapies limited in addressing its complex pathophysiological mechanisms, such as inflammation, oxidative stress, apoptosis, and impaired autophagy. Glycyrrhizic acid (GA), a bioactive compound from licorice ( L.), has demonstrated neuroprotective properties in preclinical studies.

Recent advances in nanomaterial-enabled chemiresistive hydrogen sensors.

With the growing adoption of hydrogen energy and the rapid advancement of Internet of Things (IoT) technologies, there is an increasing demand for high-performance hydrogen gas (H) sensors. Among various sensor types, chemiresistive H sensors have emerged as particularly promising due to their excellent sensitivity, fast response times, cost-effectiveness, and portability. This review comprehensively examines the recent progress in chemiresistive H sensors, focusing on developments over the past five years in nanostructured materials such as metals, metal oxide semiconductors, and emerging alternatives.

Logically Activatable Nanoreporter for Multiplexed Time-Phased Imaging Assessment of Hepatic Ischemia-Reperfusion Injury and Systemic Inflammation.

Hepatic ischemia-reperfusion injury (HIRI) and induced systemic inflammation is a time-dependent multistage process which poses a risk of causing direct hepatic dysfunction and multiorgan failure. Real-time in situ comprehensive visualization assessment is important and scarce for imaging-guided therapeutic interventions and timely efficacy evaluation. Here, a logically activatable nanoreporter (termed QD@IR783-TK-FITC) is developed for time-phase imaging quantification of HIRI and induced systemic inflammation.

Enhancing the Photocatalytic Activity of Lead-Free Halide Perovskite CsBiI by Compositing with TiC MXene.

In recent years, halide perovskite materials have become widely used in solar cells, photovoltaics, and LEDs, as well as photocatalysis. Lead-free perovskite CsBiI has been demonstrated as an effective photocatalyst; however, the fast recombination of the photogenerated carriers hinders further improvements of its photocatalytic activity. In this work, TiC was composited with CsBiI to promote the transfer and separation of photogenerated carriers, and thus the pollutant degradation efficiency was effectively improved.

Fabrication of Functionalized Graphene Oxide-Aluminum Hypophosphite Nanohybrids for Enhanced Fire Safety Performance in Polystyrene.

To enhance the fire safety performance in polystyrene (PS), a novel organic-inorganic hybrid material (FGO-AHP) was successfully prepared by the combination of functionalized graphene oxide (FGO) and aluminum hypophosphite (AHP) via a chemical deposition method. The resulting FGO-AHP nanohybrids were incorporated into PS via a masterbatch-melt blending to produce PS/FGO-AHP nanocomposites. Scanning electron microscope images confirm the homogeneous dispersion and exfoliation state of FGO-AHP in the PS matrix.

Dual frequency composite pattern temporal phase unwrapping for 3D surface measurement.

Phase shifting profilometry (PSP) is widely used in three-dimensional (3D) optical metrology applications such as mechanical engineering, industrial monitoring, computer vision, and biomedicine because of its high measurement accuracy. In PSP, multi-frequency temporal phase unwrapping (TPU) plays a dominant role due to its high-accuracy measurement of surfaces with discontinuities and isolated objects. However, it requires a large number of fringe patterns.