J Trace Elem Med Biol
January 2025
Objective: This study aims to investigate the association of serum iodine concentration (SIC) with thyroid function-associated parameters in pregnant women in mild iodine deficient area, and explore its potential to predict individual iodine nutrition status in pregnant women.
Methods: A total of 741 pregnant women undergoing prenatal examinations in their second trimester at the Women's Hospital, Zhejiang University School of Medicine, from March 2021 to May 2022 were finally recruited into the study. Venous blood and morning urine were collected.
The blood proteome contains biomarkers of ageing and age-associated diseases, but such markers are rarely validated longitudinally. Here we map the longitudinal proteome in 7,565 serum samples from a cohort of 3,796 middle-aged and elderly adults across three time points over a 9-year follow-up period. We pinpoint 86 ageing-related proteins that exhibit signatures associated with 32 clinical traits and the incidence of 14 major ageing-related chronic diseases.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Early detection of autism spectrum disorder (ASD) is particularly important given its insidious qualities and the high cost of the diagnostic process. Currently, static functional connectivity studies have achieved significant results in the field of ASD detection. However, with the deepening of clinical research, more and more evidence suggests that dynamic functional connectivity analysis can more comprehensively reveal the complex and variable characteristics of brain networks and their underlying mechanisms, thus providing more solid scientific support for computer-aided diagnosis of ASD.
View Article and Find Full Text PDFIntelligent transportation systems heavily rely on forecasting urban traffic flow, and a variety of approaches have been developed for this purpose. However, most current methods focus on exploring spatial and temporal dependencies in historical traffic data, while often overlooking the inherent spectral characteristics hidden in traffic time series. In this paper, we introduce an approach to analyzing traffic flow in the frequency domain.
View Article and Find Full Text PDFDrought, a major consequence of climate change, initiates molecular interactions among genes, proteins, and metabolites. a high-quality perennial grass species, exhibits robust drought resistance. However, the molecular mechanism underlying this resistance remaining largely unexplored.
View Article and Find Full Text PDFPurpose: This study aimed to examine the impact of APS on acute kidney injury induced by rhabdomyolysis (RIAKI), exploring its association with macrophage M1 polarization and elucidating the underlying mechanisms.
Methods: C57BL/6J mice were randomly assigned to one of three groups: a normal control group, a RIAKI model group, and an APS treatment group. Techniques such as flow cytometry and immunofluorescence were employed to demonstrate that APS can inhibit the transition of renal macrophages to the M1 phenotype in RIAKI.
Perihematomal edema (PHE) significantly aggravates secondary brain injury in patients with intracerebral hemorrhage (ICH), yet its detailed mechanisms remain elusive. Neutrophil extracellular traps (NETs) are known to exacerbate neurological deficits and worsen outcomes after stroke. This study explores the potential role of NETs in the pathogenesis of brain edema following ICH.
View Article and Find Full Text PDFBackground: The EAT-Lancet diet was reported to be mutually beneficial for the human cardiometabolic system and planetary health. However, mechanistic evidence linking the EAT-Lancet diet and human cardiometabolic health is lacking.
Objectives: We aimed to investigate the role of blood proteins in the association between the EAT-Lancet diet and cardiometabolic health and explore the underlying gut microbiota-blood protein interplay.
This study investigates lignin's influence on the hygroscopic behavior of poplar wood. Delignification was achieved using an acidic NaClO solution, and digital image correlation (DIC) was employed to measure strain distribution during shrinking and swelling across relative humidity (RH) ranging of 0 % to 97 %. Results showed that lignin removal increased equilibrium moisture content (EMC) by up to 3.
View Article and Find Full Text PDFObjectives: This study aimed to assess the need for adding heparin to parenteral nutrition (PN) on reducing catheter intraluminal obstruction based on scanning electron microscopy (SEM) of peripherally inserted central catheter (PICC) in preterm neonates.
Methods: In this randomized controlled blinded non-inferiority trial, neonates with gestational age <32 weeks requiring PICC to receive PN were enrolled and randomly divided into two groups. In the heparin group, 0.
Objective: To explore the mechanism of HIF-1α promoting the proliferation, invasion and metastasis of nasopharyngeal carcinoma cells by regulating the expression of MMP-2.
Methods: 30 nasopharyngeal carcinoma tissues and 30 normal nasopharyngeal epithelial tissues were collected, and the expression of HIF-1α and MMP-2 in the nasopharyngeal carcinoma, normal nasopharyngeal epithelial tissues and their hypoxic environment were systematically analyzed by qRT-PCR and western blot techniques. Lentivirus transfection technology was used to regulate the expression of HIF-1α and MMP-2 genes in the HONE1 cell line under hypoxic environment, and to explore the interaction mechanism of HIF-1α and MMP-2 genes and their role in the proliferation, invasion and metastasis of nasopharyngeal carcinoma.
Conservation agriculture practices (CAs) are important under the increasingly serious soil quality degradation of sloping farmlands worldwide. However, little is known about how the long-term application of CAs influences soil quality at different slope positions. We conducted field experiments for a watershed sloping farmland's mainstream planting systems in the Three Gorges Reservoir area of China.
View Article and Find Full Text PDFSarcopenia and AD are both classic degenerative diseases, and there is growing epidemiological evidence of their comorbidity with aging; however, the mechanisms underlying the biology of their commonality have not yet been thoroughly investigated. APP is a membrane protein that is expressed in tissues and is expressed not only in the nervous system but also in the NMJ and muscle. Deposition of its proteolytic cleavage product, Aβ, has been described as a central component of AD pathogenesis.
View Article and Find Full Text PDFBackground: The interplay between diet and gut microbiome substantially influences host metabolism, but uncertainties remain regarding their relationships tailored for each subject given the huge inter-individual variability. Here we aim to investigate diet-gut microbiome interaction at single-subject resolution and explore its effects on blood glucose homeostasis.
Methods: We conducted a series of nutritional n-of-1 trials (NCT04125602), in which 30 participants were assigned high-carbohydrate (HC) and low-carbohydrate (LC) diets in a randomized sequence across 3 pair of cross-over periods lasting 72 days.
The COVID-19 pandemic has increased the co-occurrence of quaternary ammonium compounds (QACs) and antidepressants in aquatic environments. Microalgae are sustainable and cost-effective candidates for removing emerging pollutants. QACs have a robust ability to adsorb on cell surface and alter membrane permeability, but little is known about the influence of QACs on microalgal bioremediation of co-existing pollutants like antidepressants.
View Article and Find Full Text PDFFluorescence imaging and recognition are core technologies in targeted medicine, pathological surgery, and biomedicine. However, current imaging and recognition systems are separate, requiring repeated data transfers for imaging and recognition that lead to delays and inefficiency, hindering the capture of rapidly changing physiological processes and biological phenomena. To address these problems, we propose an integrated intelligent sensor for biological fluorescence imaging and ultrafast recognition.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
November 2024
Background: This meta-analysis was performed to obtain a comprehensive overview of the differences between once-weekly basal insulin (including icodec and basal insulin Fc) and once-daily basal insulin (including glargine and degludec) in patients with type 1 and type 2 diabetes mellitus.
Methods: PubMed, EMBASE, and Cochrane Library were systematically searched for eligible studies up to 2 January 2024.
Results: A total of 12 studies were included, comprising 5,895 patients, with 3,104 (52.
Cell Mol Neurobiol
November 2024
Regional neuropathic pain syndromes above, at, or below the site of spinal damage arise after spinal cord injury (SCI) and are believed to entail distinct pathways; nevertheless, they may share shared defective glial systems. Neuropathic pain after SCI is caused by glial cells, ectopic firing of neurons endings and their intra- and extracellular signaling mechanisms. One such mechanism occurs when stimuli that were previously non-noxious become so after the injury.
View Article and Find Full Text PDFMicromachines (Basel)
October 2024
This study introduces a novel method for the simultaneous detection of microwave sensor power and temperature, leveraging nitrogen-vacancy (NV) centers as a robust quantum system. Through precise measurement of the optical detection magnetic resonance contrast in NV centers, the microwave power is accurately determined. Furthermore, the temperature of the sensor is obtained by monitoring the variations in zero-field splitting and thorough spectral analysis.
View Article and Find Full Text PDFThis study aimed to investigate the serum biochemical markers' propensity associated with sex chromosome abnormalities (SCAs) and assess the clinical efficacy of SCAs in serum biochemical screening during the second trimester. A retrospective case-control analysis was conducted on pregnant women who underwent serum biochemical screening during the second trimester. The study compared groups of women with SCAs to those with normal chromosome karyotypes to assess changes in biochemical markers.
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