Publications by authors named "Tang Cheng"

Calycosin, the main extract from the traditional Chinese medicine (TCM) Astragalus membranaceus, has demonstrated anti-osteoporotic properties in ovariectomized (OVX) mice. However, the specific pathways through which it prevents osteoporosis remain unexplored. This study aimed to investigate the pathways by which calycosin promotes autophagy in bone marrow mesenchymal stem cells (BMSCs) and alleviates ovariectomy-induced osteoporosis.

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Aichivirus D (AiV-D), a newly emerging member of the genus, is associated with diarrhea in cattle. This study aimed to investigate the prevalence and molecular characteristics of AiV-D among dairy cattle in China. From October 2021 to August 2022, 279 fecal samples were collected from diarrheal dairy cattle across seven provinces in China.

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The Otopetrin (Otop) proteins, comprising Otop1-3, are proton-gated proton channels with key biological functions. Otop1 acts as a receptor for sour and ammonium salt tastes in mammals, but its gating mechanisms and pharmacology remain poorly understood. Here, we report the functional characterization of three small molecule positive allosteric modulators of Otop1-MFaN, HIMOP, and B2FAMP-that enhance proton gating in a pH-dependent manner, potentiating Otop1 activity under weak acidic but not strong acidic conditions.

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Background: During the COVID-19 pandemic, we continuously monitored the epidemiology of influenza virus among pediatric patients from January 2021 to December 2023 in Hainan Island, China.

Methods: In this study, we collected 54,974 nasopharyngeal swab samples for influenza A Virus (IAV) testing and 53,151 samples for influenza B Virus (IBV) testing from pediatric outpatients. Additionally, we also collected 19,687 nasopharyngeal swab samples from pediatric inpatients for IAV and IBV testing.

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Tin-lead metal halide perovskites show promise as light-absorbing materials with a tunable band gap (1.2-1.4 eV) for efficient perovskite solar cells (PSCs) with less toxicity.

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Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. Dysregulation of macrophage immunometabolism has been closely implicated in several metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), hypertension, atherosclerosis, and gout, which positions macrophages as potential therapeutic targets. Recently, several natural products that target macrophage metabolic pathways have shown significant efficacy in managing metabolic diseases; however, a systematic review of these findings has yet to be conducted.

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Objective: The C-reactive protein/Lymphocyte Ratio (CLR) is a novel biomarker whose role in the development of chronic kidney disease (CKD) is not well understood. This study aimed to investigate the correlation between CLR and the prevalence of CKD.

Methods: This cross-sectional study included participants from the US National Health and Nutrition Examination Survey conducted between 1999 and 2010.

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Background: Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNAs in LC through meta-analysis.

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Molecular glue degraders induce "undruggable" protein degradation by a proximity-induced effect. Inspired by the clinical success of immunomodulatory drugs, we aimed to design novel molecular glue degraders targeting GSPT1. Here, we report the design of a series of GSPT1 molecular glue degraders.

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Introduction: Bovine coronavirus (BCoV) is an important pathogen of enteric and respiratory disease in cattle, resulting in huge economic losses to the beef and dairy industries worldwide. A specific and sensitive detection assay for BCoV is critical to the early-stage disease prevention and control.

Methods: We established a specific, sensitive, and stable assay for BCoV nucleic acid detection based on CRISPR/Cas13a combined with reverse transcription recombinase-aided amplification (RT-RAA) technology.

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Background: Research on achieving a good death for terminally delirious patients is scarce, with limited knowledge about the level of good death and influencing factors. This study investigates the level of good death among delirium patients, factors influencing it, and the correlation between distress, end-of-life care needs, and achieving a good death by surveying bereaved family members of deceased patients in Chinese hospitals.

Methods: This cross-sectional study from January 2022 to January 2024 was conducted among bereaved family members of patients using an online questionnaire.

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Introduction: Health education, weight control and exercise therapy are recognised treatment options for the non-surgical management of knee osteoarthritis (KOA); however, the pain and muscle fatigue associated with exercise make it difficult for patients to initially adhere. Traditional Chinese medicine (TCM) massage is an important complementary and alternative therapy that can effectively address these deficiencies. According to TCM theory and preliminary clinical practice, loosening of the muscles while pointing to acupoints can promote the recovery of KOA.

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Background: Many of the ligand affinity analyses are presented in water environment, and the hydrophilic solution such as methanol is used for dissociating the bound compounds. The obtained dissociation solution needs to be concentrated for improving the sensitivity of the assay. However, it is not good for the analysis of hydrophobic and volatile compounds such as coumarins.

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Diquat (DQ), a contact herbicide extensively utilized in both agricultural and nonagricultural domains, exhibits a high correlation with neuronal disorders. Nevertheless, the toxicity and underlying mechanisms associated with exposure to environmental concentrations of DQ remain ambiguous. Here, we report dose-dependent cellular neurotoxicity of DQ in .

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Purpose: To evaluate the utility of apparent diffusion coefficient (ADC) values of extraocular muscles (EOMs) in differentiating activity of thyroid eye disease (TED).

Method: Forty-two TED patients who underwent diffusion tensor imaging(DTI) were retrospectively enrolled in this study, including 29 patients in analysis group and 13 patients in validation group. The mean, maximum and minimum ADC value of each EOM were regarded as ADCmean, ADCmax and ADCmin.

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The peptide toxin SsTx-4 derived from venom of centipede Scolopendra subspinipes mutilans was characterized as a potent antagonist of the inwardly rectifying potassium (Kir) channel subtypes Kir1.1, Kir4.1, and Kir6.

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Article Synopsis
  • - Antagonists like Ziconotide and Gabapentin target CaV2.2 calcium channels to relieve chronic pain, but their clinical use is limited due to issues like narrow therapeutic windows and potential for misuse or side effects.
  • - A new compound called C2230 has been identified as a blocker of CaV2.2 channels, showing multiple beneficial effects such as trapping the channel in an inactivated state and specifically targeting pain without affecting other ion channels or motor functions.
  • - C2230 effectively reduced pain-like behaviors in various animal models and human neurons, suggesting it could be developed as a new analgesic with a unique binding mechanism that differentiates it from existing treatments.
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Background: In patients with thalassemia, different organs are affected differently by iron overload. Nevertheless, the reasons for this could be the same key transporters. This study investigated the iron deposition in different organs of transfusion-dependent thalassemia (TDT) patients and its correlation.

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Article Synopsis
  • Researchers developed a new type of hydrogen sulfide (HS) donor called sydnthiones, which allows for controlled release of HS in biological settings.
  • The study demonstrates the reactive capabilities of sydnthiones with strained alkynes (specifically dibenzoazacyclooctyne or DIBAC) and compares these reactions to other bioorthogonal pairs for selective labeling and drug release.
  • Findings reveal that pre-treating H9c2 cells with sydnthione and DIBAC significantly improves cell viability when exposed to the chemotherapeutic drug doxorubicin.
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Accurate analysis of social behaviors in animals is hindered by methodological challenges. Here, we develop a segmentation tracking and clustering system (STCS) to address two major challenges in computational neuroethology: reliable multi-animal tracking and pose estimation under complex interaction conditions and providing interpretable insights into social differences guided by genotype information. We established a comprehensive, long-term, multi-animal-tracking dataset across various experimental settings.

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Article Synopsis
  • The study explored how oxalate-based Ni-Fe metal-organic frameworks (MOFs) perform in the oxygen evolution reaction (OER) using the ligand 2,2'-bpy to enhance catalytic efficiency.
  • The transformation of the MOF structure involving [M(2,2'-bpy)] led to significantly improved OER performance, achieving a low overpotential of 220 mV in a KOH solution, outpacing standard oxalate-based Ni-Fe MOFs.
  • However, too much 2,2'-bpy decreased catalytic activity, illustrating its dual role in either promoting or inhibiting reactions, and pointing to the importance of secondary ligands in optimizing catalytic performance.
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Article Synopsis
  • - TRPV1 is an ion channel involved in pain sensation, particularly in the development of hyperalgesia, but its decline during pain relief hasn't been thoroughly studied.
  • - Research shows that S-palmitoylation modifies TRPV1's function by promoting its degradation, which helps alleviate inflammatory pain.
  • - The enzyme ZDHHC4 adds palmitoyl groups to TRPV1, while APT1 removes them, revealing a balance that influences pain responses.
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