Publications by authors named "Tandi Ge"
Article Synopsis
- The study focuses on the Dll4-Notch1 signaling pathway, which is critical for blood vessel formation and specificity, noting that blocking this pathway can lead to excessive angiogenesis.
- Researchers developed a peptide called TAT-ANK that inhibits this signaling by competing with activated Notch1, which was tested in both lab (in vitro) and animal (in vivo) settings to assess its effects on blood vessel formation.
- The results indicate that TAT-ANK effectively reduces Dll4 expression and Notch1 activation, promoting angiogenesis, making it a potentially valuable tool for future research and treatment of diseases linked to blood vessel growth.
The major pathogenesis of proliferative vitreoretinopathy (PVR) is that retinal pigment epithelial (RPE) cells undergo epithelial-mesenchymal transition (EMT) because of disordered growth factors, such as TGF-β, in the vitreous humor. Bone morphogenetic proteins (BMPs) are pluripotent growth factors. In this study, we identified the antifibrotic activity of BMP7 in a PVR model both in vivo and in vitro.
View Article and Find Full Text PDF