Publications by authors named "Tanawadee Khumpanied"
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) poses a challenge due to its complex nature and limited treatment options, leading to side effects and low survival rates with standard therapies.
- Research on halogenated benzoate derivatives of cleistanthin A revealed that ECDD-S18 was highly effective against HNSCC cells, outperforming the chemotherapy drug cisplatin while causing minimal harm to normal cells.
- ECDD-S18 promotes cancer cell death by disrupting lysosomal function and autophagy, along with downregulating mesenchymal markers and inhibiting cell migration, suggesting it holds potential as a therapeutic agent, especially in combination with drugs like cisplatin.
A poor outcome for cholangiocarcinoma (CCA) patients is still a clinical challenge. CCA is typically recognized by the desmoplastic nature, which accounts for its malignancy. Among various extracellular matrix proteins, laminin is the most potent inducer for CCA migration.
View Article and Find Full Text PDFEvery year, dengue virus (DENV) affects millions of people. Currently, there are no approved drugs for the treatment of DENV infection. Autophagy is a conserved degradation process that was shown to be induced by DENV infection and required for optimal DENV replication.
View Article and Find Full Text PDFAutophagy induction by starvation has been shown to enhance lysosomal delivery to mycobacterial phagosomes, resulting in the restriction of the Mycobacterium tuberculosis reference strain H37Rv. In contrast to H37Rv, our previous study showed that strains belonging to the notorious M. tuberculosis Beijing genotype could evade autophagic elimination.
View Article and Find Full Text PDFArticle Synopsis
- There's a new type of tuberculosis called "MKR superspreader" that spreads quickly and is hard to treat because it's resistant to many drugs.
- In experiments, scientists found that this MKR strain grows faster in immune cells (macrophages) than a standard strain.
- They discovered that certain genes in these immune cells react differently to the MKR strain, which could help find new ways to fight this tough infection.
Article Synopsis
- Mycobacterium tuberculosis has ways to avoid being destroyed by immune cells, but starving the cells can help the body fight back.
- Some strains of this bacteria, like the Beijing strain, are tough and can survive even when the cells are starved.
- In this study, researchers found that a special protein called KatG helps the tough strain resist being destroyed, and they discovered that a specific type of molecule called Superoxide dismutase 2 is important for making the bacteria easier to eliminate when cells are starved.
Article Synopsis
- Researchers found that starving host cells helps deliver special recycling centers called lysosomes to fight against bacteria like Mycobacterium tuberculosis.
- A specific strain of this bacteria, called Beijing, was able to resist being eliminated by these lysosomes, and the team looked into why this happens.
- They discovered two important genes, Kxd1 and Plekhm2, which help the Beijing strain avoid being attacked by the lysosomes during starvation, letting the bacteria survive longer inside the cells.
Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features.
Sci Rep
February 2021
Article Synopsis
- Tuberculosis is a serious health issue around the world, and in Thailand, a drug-resistant version called "MKR superspreader" has been found spreading to different areas.
- Researchers studied how this strain behaves during infections and discovered it uses specific genes to break down cholesterol and grow inside human cells, which is different from another tuberculosis strain called H37Rv.
- They also found that certain drugs could help stop the MKR strain from surviving in cells, which could lead to new treatments for this tough bacteria.