Retroperitoneal Haematoma - Still a Medical Challenge for Abdominal Trauma.

The study is presenting a personal experience of a Trauma Centre Level I and is try to conclude on optimal medical attitude for patients with retroperitoneal hematoma, still a controversial topic for traumatologists. Material and Method: A retrospective analysis of 22 cases of post-traumatic retroperitoneal hematoma admitted on Bucharest Emergency Hospital between September 2018 August 2021 (including time of Covid-19 pandemic), is presented The patients (males predominance, mean age 43, mean ISS of 23), benefited of nonoperative management on admission for 10 cases (45%) with a failure rate of 4/10 due to recurrent bleeding from spleen injuries and continuous bleeding from mesenteric vessels lesions. CT scan (73% - 16 cases) within 1 hour from the admission and emergency surgery were necessary for 12 cases (55%).

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex-Compatibility Study with Pharmaceutical Excipients.

Risperidone (RSP) is an atypical antipsychotic drug used in treating schizophrenia, behavioral, and psychological symptoms of dementia and irritability associated with autism. The drug substance is practically insoluble in water and exhibits high lipophilicity. It also presents incompatibilities with pharmaceutical excipients such as magnesium stearate, lactose, and cellulose microcrystalline.

Encapsulation of Risperidone by Methylated β-Cyclodextrins: Physicochemical and Molecular Modeling Studies.

Risperidone (RSP) is an atypical antipsychotic drug which acts as a potent antagonist of serotonin-2 (5TH2) and dopamine-2 (D2) receptors in the brain; it is used to treat schizophrenia, behavioral and psychological symptoms of dementia and irritability associated with autism. It is a poorly water soluble benzoxazole derivative with high lipophilicity. Supramolecular adducts between drug substance and two methylated β-cyclodextrins, namely heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD) and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD) were obtained in order to enhance RSP solubility and improve its biopharmaceutical profile.

Recovery of Flexible Polyurethane Foam Waste for Efficient Reuse in Industrial Formulations.

Ester polyurethane (PU) foam waste was reacted at atmospheric pressure in an autoclave and using microwaves with diethylene glycol (DEG) at different PU/DEG ratios in the presence of diethanolamine as a catalyst to find the glycolysis conditions that allow for the improved recovery of the PU foam waste and enable the recycling of the whole glycolysis product in foam formulations suitable for industrial application. The recycled polyol was characterized by dynamic viscosity, hydroxyl number, water content, and density, while thermal stability was assessed using thermogravimetric analysis. In the PU foam formulation, 1% and 5% of the glycolyzed material was reused.

Initial researches on neuro-functional status and evolution in chronic ethanol consumers with recent traumatic spinal cord injury.

We found differences related to the neuro-functional deficiency and clinical progress, among non-consumers and chronic consumers of ethanol, with recent traumatic spinal cord injury (SCI). We present a synthesis of related data on lesion mechanisms in post-traumatic myelogenous disorders, namely some of the alcohols and their actions on the nervous system, with details on the influences exerted, in such afflictions, by the chronic consumption of ethanol. The subject is not frequently approached - according to a literature review with systematic elements, which we have done before - thus constituting a niche that deserves to be further explored.

Probability of Survival Scores in Different Trauma Registries: A Systematic Review.

Introduction: A mixed score to predict the probability of survival has a key role in the modern trauma systems. The aim of the current studies is to summarize the current knowledge about estimation of survival in major trauma patients, in different trauma registries.

Method: Systematic review of the literature using electronic search in the PubMed/Medline, Web of Science Core Collection and EBSCO databases.

High Grade Penetrating Pancreatic Trauma - Case Report and Review of the Literature.

Introduction: The pancreatic injuries have fortunately a low frequency, but when present associate multiple intraabdominal lesions, and carry a significant morbidity and mortality. The aim of this study is to underline the significant morbidity associated with high grade pancreatic injuries.

Case Report: Female patient, 36 years old, with penetrating abdominal trauma due to domestic violence was referred to our center from a regional county hospital, after multiple laparotomies, hemodynamically unstable, with multiple organ failure.

Most small bowel cancers are revealed by a complication.

Objective: To characterize the pattern of primary small bowel cancers in a tertiary East-European hospital.

Methods: A retrospective study of patients with small bowel cancers admitted to a tertiary emergency center, over the past 15 years.

Results: There were 57 patients with small bowel cancer, representing 0.

Traumatic Tricuspid Valve Rupture after Blunt Chest Trauma - A Case Report and Review of the Literature.

Introduction: Despite the high frequency of thoracic injuries secondary to traffic related accidents, the blunt cardiac valve rupture is extremely rare.

Method: Case report and review of the literature using PubMed/MEDLINE and EMBASE databases.

Result: A 38 year old female patient, victim of car accident was admitted.

Massive intraoperative bleeding after laparoscopic assisted abdominoperineal resection: a case report and systematic review of the literature.

Introduction: The laparoscopic-assisted abdominoperineal resection (LAPR) has been proved to be associated with a shorter postoperative recovery, with equivalent oncological results and similar survival when compared with conventional open surgery, for patients with low rectal cancer.

Method: Case report of a massive intraoperative bleeding during LAPR and systematic review of the English language literature, using PubMed Medline, ISI Thopmson, OVID and EMBASE databases.

Results: 58 years old patient admitted in emergency setting or rectal bleeding.

Epidemiology of diverticular disease -- systematic review of the literature.

Introduction: Associated with the Western diet and life style,diverticular disease is affecting more and more developing countries worldwide. Recent studies show an increase in incidence of the disease at young age, that raises the risk of complications, along with major consequences for the patient but also for the healthcare system.

Method: Systematic review of the literature with US National Library of Medicine and National Institutes of Health International PubMed Medline, using abstracts and articles available in PubMed Medline, Cochrane databases searching for ("Diverticulosis, Colonic epidemiology" [MeSH] OR"Diverticulosis, Colonic etiology" [MeSH] OR "Diverticulosis,Colonic genetics" [MeSH] OR "Diverticulosis, Colonic history" [MeSH]).

Validation and quality control of an ICP-MS method for the quantification and discrimination of trace metals and application in paper analysis: an overview.

Questioned documents analysis includes: handwriting comparison, analysis of the ink and the printer used in the production of the documents, and the physical and chemical characterization of the cellulosic substrate (paper) of the documents. In many situations in life, for financial, social, and personal concerns, we depend on different documents. Therefore, over time, various analytical methods have been developed in order to determine their authenticity, source, and age or to differentiate various papers.

Medical and surgical management of a rare and complicated case of multivisceral hydatidosis; 18 years of evolution.

Hydatidosis (echinococcosis) is a parasitic disease caused by the development in the human host of the larval form of the Echinococcus spp. tapeworm. Among the parasitic diseases transmitted from animal to human, hydatidosis represents the main Romanian helminthic zoonosis in humans, due to the severity of the clinical presentation and the complications of this illness.

Trauma registry -- a necessity of modern clinical practice.

Introduction: Traumas represent the cause of 10 % of deaths in the entire world. The successful development of trauma systems, including the use of trauma registries, played a significant part in lowering the mortality and the disabilities due to injuries resulted from trauma.

Method: Review of the literature using computerized database of National Library of Medicine and the International Institutes of Health MEDLINE using PubMed interface.

Evaluation of the metabolic balance in type 2 diabetes by assay of the hair glucose.

The authors used a relative new method of long term retrospective evaluation of metabolic balance in type 2 diabetes. This method was based on the variations of the glucose in the hair with the variations of HbA1c (r=+0.96; p<0.

The analysis of structural lipid of the hair of patients with angina pectoris.

A study of 48 patients with angina pectoris carried out, in which the structural lipids of the hair were analyzed and correlated with the manifestations of angina and the potential incidence of dyslipidemia. It was noted that the excesses of hair lipids associated with deficiencies of some unsaturated fatty acids raised the frequency of angina attacks in the group studied by 2.7 times.

Early cystinuria, a risk factor for metabolic urolithiasis.

The levels of urinary amino acids (cystine, amino acids with basic character, branched chain amino acids and phenylalanine) were determined in the 24 hr urines of 5,500 newborns and in 20 subjects ranging in age from 2.5 to 20 years, with a suspicion of metabolic diseases. Seven newborns have shown a biochemical pattern of cystinuria.

The relationship between the urinary level of some amino acids and the occurrence of metabolic diseases associated with psychic disorders.

Assays of the branched chain amino acids, of those with basic character, of phenylalanine and glutamic acid were performed in the 24 hrs urines of 50 patients with psychic disorders, ranging in age from 0 to 20 years, and in 30 normal controls. Similar investigations were carried out in the patients' parents. Abnormal levels of urinary amino acids in some of the adults suggested the existence of mutant genes in one or both parents of one or two descendents with mental handicap.

The hair levels of unsaturated fatty acids (oleic, linoleic, and linolenic) indicators of the lipid metabolic balance.

The lipid metabolism was evaluated using a new method for assay of the hair contents in unsaturated fatty acids. Determinations in various hair segments and in the blood serum were performed before and after a hypolipemic diet and drug therapy in hypercholesterolemic patients in comparison with a control group. The correlation factors between the levels of the oleic, linoleic and linolenic acids in the serum and those in the hair were +0.

Predictive value of glucose and proteic sulphur levels in the hair for an early detection of the preclinical stage of IDDM.

Assays of glucose and proteic sulphur levels in the hair of patients with recently detected IDDM provided information on the preclinical stage of insulin secretion disorders, which was estimated at 6 +/- 2 months. Such investigations in subjects at high risk of developing an IDDM might reveal the period preceding the disease onset, thus enabling to start an early therapy.

The relationship between aminoaciduria and plasma hemoglobin levels.

Investigations in newborns, children and young adults have revealed an inverse proportion between aminoaciduria and plasma hemoglobin (Hb) levels. Values above normal were recorded for alanine, leucine, valine, phenylalanine and glutamic acid, correlating proportionally with their increased blood levels, and preceding or being concomitant with the decrease of plasma Hb, both during the first 20 months of life and in young adults. The return to near normal values of aminoaciduria occurred generally only after an early treatment with minerals, vitamins and trace elements (Supradyn), activators of the enzymes involved in the amino acid metabolism.

Cholesterol and lipid levels in the hair: indicators of the lipid metabolism balance.

A new method of long term, retrospective evaluation of the lipid metabolism balance, by cholesterol and lipid assays in the human hair, is described. The correlation index between the blood and the hair cholesterol and lipid concentrations was + 0.980 and + 0.

Evaluation of the metabolic balance in type 1 (insulin-dependent) diabetics, by assay of the hair biochemical components.

A new method of long-term retrospective evaluation of the metabolic balance in type 1 diabetic was based on the variations of the hair biochemical components. Glucose, proteic sulfur and amino acid assays were performed in two consecutive hair segments, proximal and distal, of 1.5 cm each.

A polarographic study of some complexes of Tl(I) with polyoxa macrocyclic ligands.

The log beta(1) values at 25 degrees for the reaction in aqueous solution of Tl(I) with 15-crown-5, benzo-15-crown-5, 18-crown-6 and dicyclohexyl-18-crown-6 (isomer cis-syn-cis) have been determined by d.c. and a.