TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study.

Transmembrane protease serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease family known to be upregulated in many malignancies. We previously showed that TMPRSS4 may be a prognostic biomarker and therapeutic target for gastric cancer (GC), especially in stage III. In this retrospective study conducted at 10 institutions, all 325 patients underwent R0 resection involving D2 lymph node dissection.

[A Clinicopathological Study of Nine Cases with Primary Small Bowel Adenocarcinoma].

We analyzed the clinicopathological features and prognosis of 9 patients with primary small bowel adenocarcinoma, excluding duodenal cancer, between January 2009 and February 2024 at our hospital. The mean age of the patients was 68.9(60-82)years, and the male to female ratio was 7 : 2.

[A Case of Transverse Colon Cancer with Intestinal Malrotation].

The patient was a 73-year-old female with left lower abdominal pain. Colonoscopy revealed a tumor in the transverse colon, which was biopsied and diagnosed as a well-differentiated adenocarcinoma. Computed tomography revealed incomplete formation of the ligament of Treitz, with the small bowel located in the right abdomen and the ascending colon along the midline.

[Short and Long-Term Outcomes and Problems of Colorectal Cancer Surgery for Patients Aged 90 Years and Older].

Background: In Japan, the fastest aging country in the world, colorectal cancer(CRC)patients at least 90 years old are rapidly increasing.

Materials And Methods: Among CRC patients who received resection of primary lesions between 2014 and 2023, we retrospectively compared and examined 24 cases of CRC aged 90 years or older(SE group)with non-elderly patients aged 50 to 74 years(NE group).

Results: SE group had significantly poorer nutritional indexes and anemia.

[A Case of Gastric Cancer Diagnosed from Ovarian Metastasis and Underwent Laparoscopic Proximal Gastrectomy after Neoadjuvant Chemotherapy].

The prognosis of patients with gastric cancer and ovarian metastasis is extremely poor, with many studies reporting survival durations within 1-2 years after diagnosis. The patient in this study was a 64-year-old female who visited a local hospital with lower abdominal pain and was referred to our hospital's gynecology department for follow-up of uterine fibroids. MRI revealed a right ovarian tumor and upper gastrointestinal endoscopy revealed gastric cancer in the upper stomach.

High risk of multiple gastric cancers in Japanese individuals with Lynch syndrome.

Aim: Lynch syndrome (LS) is a dominantly inherited syndrome characterized by an increased risk for LS associated tumors such as colorectal cancer (CRC) and gastric cancer (GC). However, the clinical benefit of surveillance for GC remains unclear while it has already been recommended for CRC. This study aimed to elucidate the clinical features of GC in Japanese individuals with LS, and the risk of developing multiple GCs to build regional-tailored surveillance programs in LS patients with GC.

Lynch Syndrome Screening and Surveillance Trends among Gastroenterologists in Japan: A Questionnaire Survey-based Analysis.

Objective Screening and surveillance methodologies for Lynch syndrome (LS) in Japan. This study assessed the changes in LS knowledge and practice trends. Methods In 2020 and 2022, 2 questionnaire surveys were administered to 3574 councilors of the Japanese Society of Gastroenterology to assess changes in LS-related knowledge and practices.

Two cases of sigmoid colon cancer with intussusception prolapsing through the anus in adults: consideration of preoperative reduction and surgical approaches: case reports.

Background: Adult intussusception is a rare condition that is often associated with a high incidence of malignancy. The optimal management strategy remains controversial, particularly regarding the necessity for bowel reduction before resection. To date, there is a paucity of data on adult intussusception in the English literature.

A Case of Gallbladder Metastasis of Malignant Melanoma.

In the clinical course of malignant melanoma, which can metastasize to multiple organs, gallbladder metastases are rarely detected. A 69-year-old man who underwent resection of a primary malignant melanoma was subsequently treated with nivolumab for lung metastases and achieved complete response. Seven years after surgery, multiple nodules were found in the gallbladder, and he underwent laparoscopic cholecystectomy.

Risk of metachronous colorectal cancer after surgical resection of index rectal cancer in Lynch syndrome: a multicenter retrospective study in Japan.

Purpose: This study evaluated the risk of metachronous colorectal cancer (CRC) after resection of index (first) rectal cancer in patients with Lynch syndrome (LS).

Methods: Clinicopathological data of patients with genetically proven LS were retrospectively analyzed in this multicenter Japanese study. The cumulative incidence of metachronous CRC and the overall survival were compared between patients with index rectal cancer (rectal group) and those with index colon cancer (colon group).

[Two Cases of Closed LECS for Early Gastric Cancer].

In recent years, laparoscopy and endoscopy cooperative surgery(LECS)is reported as the treatment of gastric cancer. We report closed LECS performed for an elderly patient with remnant gastric cancer and gastric cancer in a patient with lung cancer. Case 1 is an 85-year-old male.

Rare case of retroperitoneal mitotically active leiomyoma in a postmenopausal woman.

Leiomyomas are benign smooth muscle tumors, and retroperitoneal leiomyomas without coexisting uterine leiomyomas are extremely rare. Mitotically active leiomyomas, which are leiomyomas with increased mitotic activity, are rarely observed in postmenopausal women, except under the influence of exogenous hormones. This report presents a rare case of a retroperitoneal mitotically active leiomyoma in a postmenopausal woman.

The pathogenic role of the BRCA2 c.7847C>T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition.

Substantial numbers of variants of unknown significance (VUSs) have been identified in BRCA1/2 through genetic testing, which poses a significant clinical challenge because the contribution of these VUSs to cancer predisposition has not yet been determined. Here, we report 10 Japanese patients from seven families with breast or ovarian cancer harboring the BRCA2 c.7847C>T (p.

[Unresectable Advanced HER2-Positive Gastric Cancer Leading to a Perforation during Chemotherapy with Trastuzumab plus Paclitaxel].

The patient was a 70s female with gastric cancer. CT and PET scans revealed metastases of para-aortic lymph nodes, hepatoduodenal ligament lymph nodes, and left supraclavicular lymph nodes. She was diagnosed with T4a, N2, M1(LYM), and cStage ⅣB and was given chemotherapy with paclitaxel due to chronic kidney disease and trastuzumab treatment.

[A Case of Inverted LECS for GIST Near the Pylorus Ring].

Laparoscopy and endoscopy cooperative surgery(LECS)is a surgical procedure to avoid excessive resection of the gastrointestinal wall and preserve its function. For gastrointestinal stromal tumors(GIST)near the cardia and pylorus ring, the function of the cardia and pylorus can be preserved by minimum excision and hand-sewn suture closures. Here, we report a case successfully treated with inverted LECS for GIST near the pylorus ring.