Publications by authors named "Tanaka Yutaka"

Hemangiomas in the head and neck region, especially those that may impact the airway, require special attention perioperatively because of the potential for difficulties with airway management and bleeding control. This case report describes the management of a 31-year-old male with a large hemangioma of the tongue and pharynx undergoing surgical extraction of mandibular third molars under intubated general anesthesia. Despite taking precautions and avoiding traumatizing the hemangioma while securing the airway, massive bleeding occurred during the surgical extractions, which prompted emergent transfer for angiographic embolization and a stay in the intensive care unit until extubation.

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We report a case in which tracheal stenosis was discovered during endotracheal intubation. A 19-year-old woman with Down syndrome was scheduled to undergo treatment of multiple dental caries under intubated general anesthesia. During the first general anesthetic, we felt some resistance while advancing the endotracheal tube through the trachea.

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Emerging evidence suggests that many conventional anticonvulsants, such as carbamazepine, phenytoin, and valproic acid, could cause cross-resistance to nondepolarizing muscle relaxants. However, there are few reports describing the interactions between levetiracetam and rocuronium. This case report describes the delayed onset of rocuronium in an adult patient with intractable epilepsy on long-term levetiracetam therapy.

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  • A study explored the use of high-dose-rate interstitial brachytherapy (HDR-ISBT) as palliative treatment for an 81-year-old male with base of tongue cancer, following prior radiation and treatment.
  • The patient underwent a lower-dose external beam radiotherapy (ERT) followed by a single-fraction HDR-ISBT booster, with precautions taken to minimize infection and bleeding.
  • Post-treatment results showed significant tumor reduction, pain relief, and no complications after nearly three years, indicating HDR-ISBT could be an effective palliative care option for patients in similar situations.
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Background: The reverse-wiring technique (RWT) using a hairpin-bend wire is useful for percutaneous coronary intervention of a bifurcation lesion with an extremely angulated side branch (SB); however, it is not necessarily effective in some anatomical situations. We report a novel SB wiring technique, the U-turn wiring technique (UWT), that is useful for wiring an extremely angled SB proximal to the ectasia.

Case Summary: In the first case, the bare wire took a U-turn in the ectasia of the diagonal branch and crossed towards the angled left anterior descending artery, but a coronary dissection occurred in the diagonal branch due to the continuous wire-pushing force.

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The cell surface of is covered by a thick capsular polysaccharide. The capsule is the most important virulence factor of ; however, the complete mechanism of its biosynthesis is unknown. The capsule is composed of glucuronoxylomannan (GXM) and glucuronoxylomannogalactan (GXMGal).

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Unlabelled: The cellular surface of the pathogenic filamentous fungus is enveloped in a mannose layer, featuring well-established fungal-type galactomannan and -mannose-type galactomannan. This study reports the discovery of cell wall component in mycelium, which resembles -glycan outer chains found in yeast. The glycosyltransferases involved in its biosynthesis in were identified, with a focus on two key α-(1→2)-mannosyltransferases, Mnn2 and Mnn5, and two α-(1→6)-mannosyltransferases, Mnn9 and Van1.

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  • SGLT2 inhibitors (SGLT2is) are effective in treating acute coronary syndrome (ACS) and their impact on unstable coronary plaque is being studied in patients with type 2 diabetes.* -
  • The study analyzed data from 109 patients, comparing those treated with SGLT2is to those who were not, focusing on changes in coronary plaque using optical coherence tomography (OCT) images.* -
  • Results showed that SGLT2is significantly improved plaque stability and reduced the incidence of major cardiovascular events compared to the non-SGLT2i group.*
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  • * The study focused on ALDH1L1, an enzyme that breaks down 10-fTHF, which is often less active in hepatocellular carcinoma (HCC), leading to altered serine and glycine levels and increased accumulation of a dnPS intermediate called ZMP.
  • * HCC cells with higher ALDH1L1 expression showed decreased sensitivity to ZMP and better mitochondrial function, suggesting that low ALDH1L1 levels could make cells more responsive
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  • The study investigates how high transcatheter heart valve (THV) implantation affects coronary access after transcatheter aortic valve replacement (TAVR), using postimplantation CT scans.
  • It compares two types of THVs (Evolut R/PRO/PRO+ and SAPIEN 3) across different implantation techniques, finding that high implantation reduces conduction disturbances for both devices.
  • Despite this benefit, the high implantation technique was associated with a higher risk of THV skirt interference with coronary ostia access and increased risk of sinus sequestration in cases requiring TAVR-in-TAVR.
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Filamentous fungi belonging to the genus are known to possess galactomannan in their cell walls. Galactomannan is highly antigenic to humans and has been reported to be involved in the pathogenicity of pathogenic filamentous fungi, such as , and in immune responses. In this study, we aimed to confirm the presence of D-galactofuranose-containing glycans and to clarify the biosynthesis of D-galactofuranose-containing glycans in , a yellow fungus.

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  • Performing PCI on calcified lesions remains difficult, leading to poor outcomes due to inadequate dilation during the procedure.
  • There are various treatment devices, including intravascular lithotripsy (approved in Japan in December 2022), effective for modifying these lesions, yet the evidence supporting their use is limited.
  • This report suggests a method for determining which devices to use based on coronary imaging findings and offers expert consensus on optimal treatment selection, with an acknowledgment that these guidelines may evolve with new evidence.
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  • Fungal-type galactomannan from Aspergillus fumigatus consists of specific linkages of mannan and galactofuran, with recent findings highlighting the involvement of CmsA and CmsB in its α-core-mannan biosynthesis, yet the relevant α-(1→6)-mannosyltransferase remained unidentified.
  • Through analyzing gene disruption strains, researchers uncovered that the absence of this mannosyltransferase leads to impaired mycelial growth and reduced spore production, indicating its crucial role in fungal development.
  • The study identified AnpA as the likely α-(1→6)-mannosyltransferase, showing distinct activity and substrate recognition compared to similar
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Objective Patients in whom coronavirus disease 2019 (COVID-19) was suspected or confirmed between January 1, 2020, and October 31, 2021, were enrolled from Japanese hospitals in this multicenter, retrospective, observational study. Methods Data on the treatment administered (including conventional and Kampo medicine) and changes in common cold-like symptoms (such as fever, cough, sputum, dyspnea, fatigue, and diarrhea) were collected from their medical records. The primary outcome was the number of days without a fever (with a body temperature <37°C).

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Schizosaccharomyces japonicus is a dimorphic yeast, transiting between unicellular and hyphal growth. The glycoproteins of fission yeast contain, in addition to mannose (Man), a large number of galactose (Gal) residues. Previously, we reported that the cell-surface O-glycans of S.

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  • * Researchers examined 140 patients with severe AS, analyzing a total of 164 vascular segments and categorizing them into four groups based on their FFR and iFR measurements.
  • * They found that 29.3% of cases exhibited discordance, predominantly negative discordance (where iFR is lower but FFR is higher), particularly in the left anterior descending artery and when peak velocity was 5.0 m/s or more.
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Objectives: Although a distal radial artery (DRA) approach has recently been used in patients undergoing cardiac catheterization, no studies have so far investigated the safety and feasibility of DRA in patients undergoing hemodialysis (HD). We aimed to investigate the incidence of conventional radial artery (CRA) occlusion and puncture site complications after DRA puncture in patients undergoing HD.

Methods: We retrospectively analyzed the data of 117 consecutive patients with HD who underwent coronary angiography or percutaneous coronary intervention via a DRA approach at our institution from September 2017 to December 2019.

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The fungal cell wall is necessary for survival as it serves a barrier for physical protection. Therefore, glycosyltransferases responsible for the synthesis of cell wall polysaccharides may be suitable targets for drug development. Mannose is a monosaccharide that is commonly found in sugar chains in the walls of fungi.

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  • - The Rosaceae family includes various fruits like peach, apple, and strawberry, with specific allergens such as Bet v 1, profilin, and lipid transfer proteins (LTP) causing oral and generalized allergic reactions.
  • - A case study of a 15-year-old boy revealed he had generalized allergic symptoms triggered by strawberry when coupled with exercise, confirmed through an oral food challenge test.
  • - The study highlights strawberry GRP as a potential allergenic component responsible for exercise-induced symptoms in this case, marking the first investigation into this relationship and indicating a need for further research on strawberry allergies.
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