Publications by authors named "Tanaka Muzenda"
Article Synopsis
- The Tshepo Study is a large-scale clinical trial conducted in southern Africa to evaluate the efficacy and tolerability of protease inhibitor-sparing combination antiretroviral therapy (cART) among ARV-naive adults infected with HIV-1 subtype C.
- The study involved 650 participants and compared different combinations of nucleoside and nonnucleoside reverse transcriptase inhibitors, alongside varying adherence strategies, to understand their impact on treatment outcomes.
- Results indicated that a specific combination (ZDV + ddI) was deemed inferior for preventing virologic failure, leading to its discontinuation, while the study included diverse demographics, with a majority of female participants.
Background: The ability of nucleoside reverse transcriptase inhibitors (NRTIs) to inhibit human mitochondrial polymerase-gamma results in impaired synthesis of mitochondrial enzymes that generate adenosine triphosphate (ATP) by oxidative phosphorylation. This has been associated with several long-term mitochondrial toxicities, which include lactic acidosis and pancreatitis, peripheral neuropathy, and lipoatrophy.
Methods: Enrolled highly active antiretroviral therapy (HAART)-treated adults have completed nearly 2 years of follow-up as part of the ongoing randomized clinical trial Adult Antiretroviral Treatment and Drug Resistance (Tshepo) study.