Publications by authors named "Tanaka Koji"
We encountered a single case in which a transition between orthodromic reciprocating tachycardia with a concealed nodoventricular pathway and atrioventricular nodal reentrant tachycardia with a bystander nodoventricular pathway was observed.
View Article and Find Full Text PDFEsophageal cancer is a highly aggressive disease, and acquired resistance to chemotherapy remains a significant hurdle in its treatment. mtDNA, crucial for cellular energy production, is prone to mutations at a higher rate than nuclear DNA. These mutations can accumulate and disrupt cellular function; however, mtDNA mutations induced by chemotherapy in esophageal cancer remain unexplored.
View Article and Find Full Text PDFPurpose: To investigate the impact of foveal glial tissue on the anatomical and functional results after macular hole (MH) surgery.
Methods: This study included 141 consecutive eyes that underwent successful vitrectomy for full-thickness MH between January 2015 and December 2022. The best-corrected visual acuity (BCVA) and the length of outer retinal defects were evaluated preoperatively and at 6 months postoperatively.
DNA methylation is known to be involved in tumor progression. This is the first study to perform an extensive methylation analysis of plasma circulating tumor DNA (ctDNA) using targeted bisulfite sequencing in gastric cancer (GC) patients to evaluate the usefulness of ctDNA methylation as a new biomarker. Sixteen patients who received chemotherapy for recurrent GC were included.
View Article and Find Full Text PDFAims: To elucidate the meaning of recovery for mothers who have experienced difficulties in child-rearing, using insights gained through their activities as mother-to-mother peer supporters.
Design: Phenomenological study.
Methods: From January to October 2022, semi-structured interviews were conducted with 11 mothers active as peer supporters at community child-rearing support centres in Japan.
Background: The association between tumor-infiltrating lymphocytes and tumor immunity has long been recognized. Among T-cell types, CD45RO-positive memory T cells (CD45RO) are reported to correlate with survival in several cancer types, but clinical evidence is lacking in esophageal squamous cell carcinoma (ESCC).
Methods: In surgical specimens from 162 preoperatively untreated patients, immunohistochemistry for CD45RO was performed to evaluate the density of CD45RO in the tumor core (CT) and invasive margin (IM) using an auto-count method.
Article Synopsis
- Hematoma expansion (HE) occurs in a significant portion of patients with acute intracerebral hemorrhage (ICH), impacting their outcomes; the study focuses on the predictive accuracy of the Black-&-White (B&W) sign in identifying HE.
- In a multicenter cohort from the PREDICT study, the association between the B&W sign and HE was analyzed, revealing that patients with the B&W sign had a higher frequency of HE and more substantial growth of hematomas compared to those without it.
- The B&W sign strongly predicts HE, with an adjusted odds ratio of 7.83 for HE and 5.67 for severe HE, indicating that its presence significantly increases the risk of hematoma expansion.
Aims: To elucidate the meaning of moral distress in nurses caring for critically ill neonates.
Design: Qualitative study using Husserl's descriptive phenomenology.
Methods: Between April and December 2022, unstructured interviews were conducted with 11 nurses with at least 3 years of neonatal intensive care unit experience in Japan.
Background: Various techniques have been used to prevent smudge on a laparoscope when inserting through trocars; however, there has been no standardized method. The purpose of this study was to compare the performance of different cleaning techniques with or without using dedicated devices, and to evaluate the features of cleaning devices.
Methods: The smudge was created in the standard 12-mm and 5-mm ports using pseudo-blood, and port cleaning was attempted using 5 different methods: (1) a surgical gauze + surgical forceps, (2) a surgical gauze + laparoscopic forceps, (3) a small laparoscopic gauze + laparoscopic forceps, (4) a cylinder-type cleaner (Endo Wiper; Osaki Medical), and (5) a swab-type cleaner (Port Cleaner; Hakuzo Medical).
Three-dimensional semiquantitative evaluation of reactive emphysema in magnesium implant models.
Minim Invasive Ther Allied Technol
November 2024
Background: Magnesium alloys have great potentials as bioabsorbable implants, whereas the difficulty in evaluating hydrogen gas produced in the degradation process has hindered their research and development. In this study, we investigated the possibility of industrial microfocus X-ray computed tomography (micro-CT) for the precise evaluation of subcutaneous emphysematous changes in a rabbit implantation model.
Methods: Magnesium plates with/without porous venting were implanted under skin defects on the backs of rabbits.
Objective: Surgical treatment for renal cell carcinoma (RCC) has drastically evolved for the past 30 years. However, survival outcomes of RCC according to times have not been fully elucidated, especially in the real-world setting. This study aimed to assess the survival improvement over time in RCC treated with nephrectomy by analyzing a longitudinal cohort using propensity score matching (PSM).
View Article and Find Full Text PDFArticle Synopsis
- * A case is reported of a 71-year-old man with recurrent gastroesophageal junction cancer who developed CAE after stenting, presenting with severe neurological symptoms and a confirmed diagnosis via CT scans.
- * Despite efforts to treat him, the patient unfortunately died shortly after showing signs of CAE, highlighting the increased risk of such complications in patients with extensive cancer treatment histories.
Article Synopsis
- Postoperative delirium is a common issue in elderly patients after gastric cancer surgery, affecting about 12.2% of those studied.
- The study analyzed 255 patients aged 75 and older, linking factors like poor Eastern Cooperative Oncology Group performance status (ECOG-PS), diabetes, and mental decline to higher delirium rates.
- The researchers found that combining scores from the Mini-Mental State Examination (MMSE) and ECOG-PS can predict delirium effectively, with 80.7% sensitivity and 74.1% specificity.
Background: Lipolysis-stimulated lipoprotein receptor (LSR), a lipid receptor, is associated with cancer progression. However, detailed effects on intracellular metabolism are unclear. We aimed to elucidate the mechanism of LSR-mediated lipid metabolism in gastric cancer.
View Article and Find Full Text PDFArticle Synopsis
- Conversion therapy, involving surgery or chemoradiotherapy, is being explored for treating esophageal squamous cell carcinoma (ESCC) patients with distant metastases, which were previously considered incurable.
- A study reviewed 147 patients who underwent conversion therapy, revealing that most had major complications post-surgery, but overall survival rates were promising, with a 5-year survival rate of 31.7% for patients who responded to treatment.
- The research concluded that conversion therapy for ESCC with distant metastasis is not only safe but also may lead to better patient outcomes, particularly for those who show a positive response to treatment.
Background: The number of metastatic lymph nodes (LNs) is an important prognostic factor for esophageal cancer, and N staging is important for prognostic stratification. The optimal cutoff values for clinical (cN) and pathologic N (pN) staging should be reconsidered following advances in neoadjuvant therapy.
Methods: The study included 655 patients who underwent esophagectomy between January 2014 and December 2016 in four high-volume centers in Japan.
Background: The association between recurrence timing and prognosis in patients with locally advanced resectable esophageal cancer undergoing neoadjuvant chemotherapy (NAC) followed by esophagectomy remains unclear. This study aimed to clarify this association using multicenter prospective clinical trial data.
Methods: Among 162 patients enrolled in a NAC phase II study comparing the efficacy of cisplatin and fluorouracil plus docetaxel with cisplatin and fluorouracil plus adriamycin, 64 patients with recurrence after R0 resection were included in this study.
Article Synopsis
- The study investigates the effects of Hochuekkito (TJ-41), a Japanese herbal medicine, on inflammation and nutritional status in cancer patients, particularly focusing on malnutrition and muscle loss (sarcopenia).
- Researchers analyzed 99 patients over 3 months, observing a significant reduction in the inflammatory marker C-reactive protein (CRP) in those with gastrointestinal cancer, especially in patients with metastatic disease.
- The findings suggest that TJ-41 could be beneficial as a complementary treatment for gastrointestinal cancer by potentially reducing inflammation and helping manage muscle loss.
Background: Existing radiological markers of hematoma expansion (HE) show modest predictive accuracy. We aim to investigate a novel radiological marker that co-localizes findings from non-contrast CT (NCCT) and CT angiography (CTA) to predict HE.
Methods: Consecutive acute intracerebral hemorrhage patients admitted at Foothills Medical Centre in Calgary, Canada, were included.
Article Synopsis
- * Imaging showed that part of his gastrointestinal tract had moved into the chest cavity, leading to the diagnosis of a diaphragmatic hernia, which required surgery.
- * During the surgery, a 12x8 cm hernia was found, and traditional mesh repair was deemed insufficient, prompting the use of a myocutaneous flap from the left rectus abdominis to successfully close the defect.
Objective: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are inflammatory cytokines produced in response to biological invasion or infection. Their levels are elevated in the blood and locally. We examined whether measuring IL-6 and TNF-α levels in serum or drainage fluid on postoperative day (POD) 1 could detect infectious complications after minimally invasive surgery for gastric cancer.
View Article and Find Full Text PDF: Indocyanine green angiography (ICGA) is often used for diagnosis of, and as an indication to apply laser treatment for, central serous chorioretinopathy (CSC). Although photodynamic therapy (PDT) is effective against CSC, the details of the mechanism are unknown. To verify the effect of PDT, we compared the time of choroidal circulation before and after PDT in CSC patients, using ICGA.
View Article and Find Full Text PDFBackground/aim: Most clear cell renal cell carcinomas (ccRCCs) have a dysfunctional von Hippel-Lindau tumor suppressor protein (VHL). Hypoxia-inducible factors 1 and 2 alpha (HIF1α and HIF2α) accumulate in ccRCC with dysfunctional VHL and up-regulate the vascular endothelial growth factor (VEGF) pathway and tumor angiogenesis. Recently, pimitespib (PIM), a potent ATP-competitive inhibitor of heat shock protein 90 (HSP90), was developed.
View Article and Find Full Text PDFBackground: Clinicians need simple and highly predictive prognostic scores to assist practical decision-making. We aimed to develop a simple outcome prediction score applied 24 hours after anterior circulation acute ischemic stroke treatment with endovascular thrombectomy and validate it in patients treated both with and without endovascular thrombectomy.
Methods: Using the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration data set (n=1764), patients in the endovascular thrombectomy arm were divided randomly into a derivation cohort (n=430) and a validation cohort (n=441).