Therapeutic switch from plasma to recombinant ADAMTS13 for patients with congenital TTP from Japanese real-world data.

Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra-rare disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and ischemic organ damage caused by pathogenic ADAMTS13 variants. ADAMTS13 containing product including fresh frozen plasma (FFP) and plasma-derived Factor VIII concentrates are commonly used to supply ADAMTS13; however, frequent hospital visits and allergic reactions are major drawbacks. A recombinant ADAMTS13 (rADAMTS13) was recently developed to address these issues.

Armadillo domain of ARID1A directly interacts with DNA-PKcs to couple chromatin remodeling with nonhomologous end joining (NHEJ) pathway.

The SWI/SNF chromatin-remodeling complex that comprises multiple subunits orchestrates diverse cellular processes, including gene expression, DNA repair, and DNA replication, by sliding and releasing nucleosomes. AT-interacting domain-rich protein 1A (ARID1A) and ARID1B (ARID1A/B), a pivotal subunit, have significant relevance in cancer management because they are frequently mutated in a broad range of cancer types. To delineate the protein network involving ARID1A/B, we investigated the interactions of this with other proteins under physiological conditions.

Approaches to tunnel magnetoresistance effect with antiferromagnets.

The tunnel magnetoresistance (TMR) effect is one of the representative phenomena in spintronics. Ferromagnets, which have a net spin polarization, have been utilized for the TMR effect. Recently, by contrast, the TMR effect with antiferromagnets, which do not possess a macroscopic spin polarization, has been proposed, and also been observed in experiments.

A morphological features-based nomogram for predicting facial nerve function in the immediate postoperative period after vestibular schwannoma surgery.

Purpose: Tumor morphology critically influences facial nerve (FN) outcomes following vestibular schwannoma (VS) surgery. This study aimed to develop a nomogram based on preoperative features for preoperative prediction of FN outcomes after VS surgery.

Methods: A retrospective analysis included patients with sporadic VS who underwent surgical resection via the retrosigmoid approach.

School Lunch and Body Size in Japanese Junior High School Students: The Japanese National Health and Nutrition Survey.

: Although the school lunch program is expected to reduce obesity and underweight among children in Japan, there had been no individual-level study examining the impact of school lunch on body size (overweight or underweight). The present study examined the association between school lunch and body size in Japanese junior high school students. : This cross-sectional study was conducted based on data from the Japanese National Health and Nutrition Survey in 2014 and 2018.

Comparison of intraocular pressure changes in Japanese patients with neovascular age-related macular degeneration treated with aflibercept or faricimab.

Purpose: To assess the short-term changes in intraocular pressure (IOP) following intravitreal injections of aflibercept or faricimab in Japanese patients with neovascular age-related macular degeneration (nAMD).

Study Design: Retrospective observational study.

Methods: This retrospective observational study included 161 eyes from 160 Japanese patients diagnosed with nAMD.

Metallothionein, an endogenous antioxidant protein, protects against acute lung injury caused by air pollutants.

Reducing deaths and diseases due to air pollution is a global challenge enshrined in the Sustainable Development Goals. Currently, there is an urgent need to discover factors that protect the lungs and bronchi, which are the first to be injured and undergo oxidative stress when air pollutants enter the body, and to establish methods to prevent their onset and progression. Metallothionein, a protein present in humans that exerts detoxification and antioxidant effects on toxic metals, has long been known to exert protective effects against liver and kidney diseases.

Recipient Toll-like Receptor 4 Determines the Outcome of Ischemia-Reperfusion Injury in Steatotic Liver Transplantation in Mice.

Toll-like Receptor 4 (TLR4) plays a crucial role in ischemia/reperfusion injury (IRI) after liver transplantation (LT). However, the role of TLR4 in the context of steatotic grafts remains unclear. In this study, we developed a mouse model to explore IRI mechanisms in steatotic LT using TLR4 knockout mice as recipients.

Detection Thresholds for Replay and Real-Time Discrepancies in VR Hand Redirection.

Hand redirection, which subtly adjusts a user's hand movements in a virtual environment, can modify perception and movement by providing real-time corrections to motor feedback. In the context of motor learning and rehabilitation, observing replays of movements has been shown to enhance motor function. The application of hand redirection to these replays by making movements appear larger or smaller than they actually are has the potential to improve motor function.

Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy.

Reactive oxygen species (ROS) are involved in the pathogenesis of generalised pustular psoriasis (GPP), but this involvement has not been fully elucidated. We performed the diacron-reactive oxygen metabolite (d-ROM) test and the biological antioxidant potential (BAP) test on sera from nine patients with active GPP who were hospitalised and treated at our hospital, including three patients with pustular psoriasis of pregnancy (PPP). The serum d-ROM and BAP levels were evaluated before treatment and at 1 month of treatment.

Gut Microbiota in Advanced Non-small-cell Lung Cancer Receiving Chemo-immunotherapy: An Ancillary Biomarker Study from the Phase III trial JCOG2007 (NIPPON).

Background: Immunotherapy has transformed treatment for non-small cell lung cancer (NSCLC). However, reliable biomarkers for treatment selection remain scarce. Gut microbiota has emerged as a potential biomarker, but its role in chemo-immunotherapy for NSCLC is unclear.

Prevalence, clinical profiles, and prognosis of Isaacs syndrome: A nationwide survey study in Japan.

Objectives: To elucidate current epidemiological, clinical, and immunological profiles, and the treatment of Isaacs syndrome in Japan.

Methods: We conducted a nationwide survey using established methods. Questionnaires were sent to neurological facilities throughout Japan to identify Isaacs syndrome patients seen between April 2018 and March 2021.

Double Prenylation of Budding Yeast Ykt6 Regulates Cell Wall Integrity and Autophagy.

Ykt6 is a conserved SNARE protein involved in multiple membrane trafficking pathways, including intra-Golgi transport and autophagic membrane fusion. We previously demonstrated that mammalian Ykt6 is uniquely modified with farnesyl and geranylgeranyl groups at two C-terminal cysteines through the sequential action of farnesyltransferase (FT) and geranylgeranyltransferase type 3 (GGT3). Although these two cysteines are strictly conserved in all eukaryotes, the evolutionary conservation of Ykt6 double prenylation remains unclear, as budding yeast appears to lack the α subunit of GGT3.

Association of Glycaemia Risk Index With Indices of Atherosclerosis: A Cross-Sectional Study.

Aims: This study determined the association of the glycaemia risk index (GRI), a novel comprehensive metric derived from continuous glucose monitoring (CGM), and atherosclerosis in patients with type 2 diabetes (T2DM).

Methods: We evaluated the relationship between GRI and intima-media thickness (IMT), gray-scale median (GSM), tissue characteristics of the carotid artery wall, and brachial-ankle pulse wave velocity (baPWV), using baseline data from a multicenter prospective cohort study of 1000 Japanese patients with T2DM free of cardiovascular disease (CVD).

Results: The study subjects were 999 patients (age: 64.

Basic verification of myocardial extracellular volume quantification by prototype photon-counting detector computed tomography: A phantom study.

Objectives: This study aimed to investigate the accuracy of myocardial extracellular volume (ECV) quantification using a prototype photon-counting detector (PCD) computed tomography (CT) and examine the association between radiation dose and spectral image settings.

Material And Methods: A multi-energy CT phantom that simulated the blood pool and myocardium was used. The tube voltage was set at 120 kVp and three types of tube current-time products (105, 150, and 300 mAs) were applied for pre- and post-contrast scans.

Metabolic engineering and cultivation strategies for efficient production of fucoxanthin and related carotenoids.

Fucoxanthin, a bioactive carotenoid derived from algae, has attracted considerable attention for its applications in health, cosmetics, and nutrition. Advances in metabolic engineering, such as the overexpression of pathway-specific enzymes and enhancement of precursor availability, have shown promising results in improving production efficiency. However, despite its high value, the biosynthetic pathway of fucoxanthin remains only partially elucidated, posing significant challenges for metabolic engineering efforts.

Global spatiotemporal optimization of photovoltaic and wind power to achieve the Paris Agreement targets.

Limiting global warming below 1.5 or 2 °C calls for achieving energy systems with net-zero carbon dioxide (CO) emissions likely by 2040 or 2070, but the pledged actions under current policies cannot meet these targets. Few studies have optimized global deployment of photovoltaic and wind power.

Inhaled nitric oxide for bronchopulmonary dysplasia-associated pulmonary hypertension: A systematic review and narrative synthesis.

Introduction: Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator. However, its effectiveness in the treatment of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) and severe BPD remains uncertain. Here we systematically reviewed whether iNO treatment increased or decreased mortality and morbidity among preterm infants with severe BPD or BPD-PH.

Revisiting the Structure of Cacospongionolide E: An Approach Based on Empirical Rules and NMR Calculations.

In the field of natural product chemistry, the structures of several marine natural products have been erroneously determined. Here, we revisited the originally proposed structure of cacospongionolide E (1) using empirical rules in C NMR chemical shift analysis and density functional theory (DFT)-based NMR chemical shift calculations. Cacospongionolide E (1) is a marine natural product isolated from the Tyrrhenian sponge Fasciospongia cavernosa.

Predictors of intraoperative and postoperative air leakage in anatomical pulmonary resection.

Purpose: Air leakage is a common complication of lung surgery that sometimes requires medical intervention and leads to a prolonged hospital stay. This study assessed the risk factors associated with air leakage following anatomical pulmonary resection.

Methods: We retrospectively analyzed 194 patients who underwent anatomical pulmonary resection in 2020.