Publications by authors named "Tanaji Mengawade"
Article Synopsis
- Researchers focused on creating reversible and selective BTK inhibitors, using 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[2,3-b]pyridine as core structures.
- They found two promising lead compounds, 11 and 13, that showed strong BTK inhibition in various cell tests and high selectivity among 50 diverse kinases.
- These compounds also displayed good pharmacokinetics in mice and had positive effects in a mouse model for arthritis.
Parkinson's disease (PD) is a very serious neurological disorder, and current methods of treatment fail to achieve long-term control. Previous studies suggest that stimulation of the metabotropic glutamate receptor 4 (mGluR4) represents a promising new approach to the symptomatic treatment of Parkinson's disease (PD). Preclinical models using both agonists and positive allosteric modulators of mGluR4 have demonstrated the potential for this receptor for the treatment of PD.
View Article and Find Full Text PDFAn efficient and convenient method for the synthesis of sugar-lactam conjugates is reported starting from readily available sugar azides using the Aubé reaction. Cyclic azido alcohols are used in the Aubé reaction for the first time in a carbohydrate setting. The resulting glycoconjugates could be further used to increase the chemical diversity on the sugar backbone, and may find potential applications as glycomimetics, peptidomimetics, in glycotargeting and in CNS drug delivery.
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