Effect of chronopharmacology and food on pharmacokinetic profile of mavacamten.

This study investigated the impact of food intake and circadian rhythms on the pharmacokinetics of mavacamten. A sensitive bioanalytical method for quantifying mavacamten in rat plasma was developed and validated. This method was applied to assess the effect of chronopharmacology and food intake on the pharmacokinetics of mavacamten in rats.

Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development.

Aldehyde oxidase (AO) has garnered curiosity as a non-CYP metabolizing enzyme in drug development due to unexpected consequences such as toxic metabolite generation and high metabolic clearance resulting in the clinical failure of new drugs. Therefore, poor AO mediated clearance prediction in preclinical nonhuman species remains a significant obstacle in developing novel drugs. Various isoforms of AO, such as , and exist across species, and different AO activity among humans influences the AO mediated drug metabolism.