Research Progress in Copper Homeostasis and Diseases.

As an indispensable trace element in the human body,copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the occurrence of related diseases.Cuproptosis,a newly proposed regulatory cell death mode,is different from the known apoptosis,pyroptosis,necroptosis,and ferroptosis.

Q fever diagnosed using metagenomic next-generation sequencing in Guangdong Province, China.

Q fever is a zoonotic disease caused by infection with (). Due to its atypical symptoms and the absence of specific detection methods, Q fever is underdiagnosed commonly. Herein, we report a case of Q fever confirmed by metagenomic next-generation sequencing (mNGS) in March 2024 in Guangdong Province, China.

Impact of Slickwater Fracturing Fluid on Pore Structure and Micromechanical Properties of Clay-Rich Shale Using Fluid Intrusion and AFM Experiments.

Multistage hydraulic fracturing leads to prolonged interactions between shale reservoirs and slickwater fracturing fluids, resulting in changes to the pore structure and micromechanical properties of the shale. However, systematic studies of the impact of shale mineral composition on hydraulic fracturing remain limited. This research investigates the effects of fracturing fluids on reservoirs with different mineral compositions, focusing on the Wufeng-Longmaxi shale in northern Guizhou, China.

Neuritin improves cognitive impairments in APP/PS1 Alzheimer's disease mice model by mitigating neuronal ferroptosis via PI3K/Akt activation.

The neurotrophic factor Neuritin is known to enhance cognitive capacity and to mitigate synaptic impairments in the APP/PS1 Alzheimer's disease (AD) mouse model, suggesting therapeutic potential for clinical treatment. However, the core molecular mechanisms remain elusive. Ferroptosis, a form of programmed cell death linked to iron dysregulation and oxidative stress, contributes to neurodegeneration in AD in part by accelerating amyloid-β deposition and neurofibrillary tangle formation.

Temporal shifts in dengue epidemic in Guangdong Province before and during the COVID-19 pandemic: a Bayesian model study from 2012 to 2022.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, the implementation of public health intervention measures have reshaped the transmission patterns of other infectious diseases. We aimed to analyze the epidemiological characteristics of dengue in Guangdong Province, China, and to investigate the temporal shifts in dengue epidemic in Guangdong Province during the COVID-19 pandemic.

Methods: Based on the data of dengue reported cases, meteorological factors, and mosquito vector density in Guangdong Province from 2012 to 2022, wavelet analysis was applied to investigate the relationship between the dengue incidence in Southeast Asian (SEA) countries and the local dengue incidence in Guangdong Province.

Tuning Corrosion Resistance and AC Soft Magnetic Properties of Fe-Co-Ni-Al Medium-Entropy Alloy via Ni Content.

Corrosion of soft magnetic materials during service can significantly impact their performance and service life, therefore it is important to improve their corrosion resistance. In this paper, the corrosion resistance, alternating current soft magnetic properties (AC SMPs) and microstructure of FeCoNiAl ( = 1.0-2.

ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling.

Background: The challenge of expanding haematopoietic stem/progenitor cells (HSPCs) in vitro has limited their clinical application. Human hair follicle mesenchymal stem cells (hHFMSCs) can be reprogrammed to generate intermediate stem cells by transducing OCT4 (hHFMSCs) and pre-inducing with FLT3LG/SCF, and differentiated into erythrocytes. These intermediate cells exhibit gene expression patterns similar to pre-HSCs, making them promising for artificial haematopoiesis.

[Research Progress in Health Hazards and Daily Intervention of Age-Related Hearing Loss].

Age-related hearing loss (ARHL) is a common chronic disease that poses a serious threat to the physical and mental health of the elderly in an aging society.It is a sensorineural hearing loss characterized by the loss of auditory hair cells,stria vascularis lesions,apoptosis of spiral ganglia,and degeneration of the auditory central nervous system,reducing the quality of life of the patients.This article reviews the research progress in the relationship of ARHL with Alzheimer's disease,depression,and frailty,as well as the daily intervention in ARHL.

[Ferroptosis:Mechanisms and Application in Tumor Treatment].

Ferroptosis is a form of regulated cell death that depends on iron and reactive oxygen species.Different from apoptosis,necrosis,and autophagy,ferroptosis is characterized by the accumulation of lipid peroxides in cells.Studies have discovered that ferroptosis is closely associated with the occurrence and development of tumors and inducing ferroptosis in tumor cells can enhance the therapeutic effects of drugs on tumors.

Evaluating treatment practices and challenges in systemic Juvenile Idiopathic Arthritis: a comprehensive survey analysis.

Objective: This study aims to assess current diagnostic and management for systemic Juvenile Idiopathic Arthritis (sJIA) among physicians, evaluate the challenges encountered in diagnosis and treatment, and identify the educational needs and professional development engagements of physicians managing sJIA.

Methods: A nationwide survey was conducted from November 2023 to March 2024 across tertiary and secondary pediatric and general hospitals in China. The survey targeted physicians with at least three years of specialty experience, resulting in 310 valid responses from 25 provinces, autonomous regions, and municipalities.

Clinical manifestations, treatment and prognosis of juvenile idiopathic arthritis with pulmonary involvement in China: a single centre study.

Objectives: In recent years, the distinct clinical presentations and elevated mortality rates of various subtypes of juvenile idiopathic arthritis (JIA) with pulmonary involvement have garnered significant attention. This study aimed to elucidate the clinical characteristics of pulmonary involvement in patients with JIA to improve clinicians' knowledge.

Methods: This single-centre retrospective study analysed the baseline data, treatment options, follow-up of sixty patients of JIA with pulmonary involvement in China.

Chinese guidelines for integrated diagnosis and treatment of intestinal microecology technologies in tumor application (2024 Edition).

Intestinal microecology (IM) is the largest and most important microecological system of the human body. Furthermore, it is the key factor for activating and maintaining the physiological functions of the intestine. Numerous studies have investigated the effects of the gut microbiota on the different tissues and organs of the human body as well as their association with various diseases, and the findings are gradually being translated into clinical practice.

NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH.

Cuproptosis is characterized by lipoylated protein aggregation and loss of iron-sulfur (Fe-S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that remove the lipoyl moiety from lipoylated proteins using nicotinamide adenine dinucleotide (NAD) as a cofactor. However, to date, it is not clear whether nicotinamide mononucleotide (NMN), a precursor of NAD, affects cellular sensitivity to cuproptosis.

Diterpenoids from the Aerial Parts of with Selective Cytotoxic Activity.

Four new diterpenoids, isodosins A-D (-), together with nine known compounds (-) were isolated and identified from the aerial parts of (Maxim.) Hara. The structures of the new diterpenoids were elucidated based on the analysis of HR-ESI-MS data, 1D/2D-NMR-spectroscopic data, and electronic circular dichroism (ECD) calculations.

Long noncoding nuclear enriched abundant transcript 1_2 is a promising biomarker for childhood-onset systemic lupus erythematosus.

Importance: Systemic lupus erythematosus (SLE) is a diffuse connective tissue disease with complex clinical manifestations and prolonged course. The early diagnosis and condition monitoring of SLE are crucial to disease prognosis.

Objective: To assess the diagnostic value of long noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) in childhood-onset SLE (cSLE).

Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma.

Background: The epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells (HBECs) is essential for airway remodeling during asthma. Wnt5a has been implicated in various lung diseases, while its role in the EMT of HBECs during asthma is yet to be determined. This study sought to define whether Wnt5a initiated EMT, leading to airway remodeling through the induction of autophagy in HBECs.

Attenuates Virulence upon Oxytetracycline Resistance.

The relationship between antibiotic resistance and bacterial virulence has not yet been fully explored. Here, we use as the research model to investigate the proteomic change upon oxytetracycline resistance (LTB4-R). Compared to oxytetracycline-sensitive (LTB4-S), LTB4-R has 234 differentially expressed proteins, of which the abundance of 84 proteins is downregulated and 15 proteins are enriched to the Type III secretion system, Type VI secretion system, and flagellum pathways.

Organic cations promote exciton dissociation in Ruddlesden-Popper lead iodide perovskites: a theoretical study.

Two-dimensional (2D) Ruddlesden-Popper perovskites (RPPs) are a class of quantum well (QW) materials showing large exciton binding energy owing to quantum confinement. The existence of localized edge states was proposed to accelerate exciton dissociation into long-lived charge carriers in 2D RPPs, but recent experimental reports suggested that highly efficient internal exciton dissociation is achievable in 2D RPPs despite the absence of edge states. Herein, we adopt first-principles calculations to unveil the physical origin of the high internal quantum efficiency in the bulk region of widely familiar (BA)(MA)PbI (BA = butylammonium; MA = methylammonium) materials.