Publications by authors named "Tan Ting Ting"

Article Synopsis
  • Immune-related adverse events (IRAEs) are common issues in patients using immune checkpoint inhibitors (ICIs), with hematological IRAEs (heme-IRAEs) like immune-induced eosinophilia being particularly under-researched.
  • This report details two cases of advanced non-small cell lung cancer (NSCLC) patients treated with pembrolizumab who developed significantly elevated eosinophil counts, highlighting differences in their treatment and outcomes.
  • After discontinuing pembrolizumab and receiving corticosteroids, both patients saw their eosinophil levels return to normal, but ultimately, one patient passed away 24 months later, underscoring the serious implications of heme-IRAEs.
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Context: Numerous studies have shown that gratitude can reduce stress and improve quality of life.

Objective: Our study aimed to examine the effect of mindful gratitude journaling on suffering, psychological distress and quality of life of patients with advanced cancer.

Methods: We conducted a parallel-group, blinded, randomised controlled trial at the University of Malaya Medical Centre, Malaysia.

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As the US transitions from volume- to value-based cancer care, many cancer centers and community groups have joined to share resources to deliver measurable, high-quality cancer care and clinical research with the associated high patient satisfaction, provider satisfaction, and practice health at optimal costs that are the hallmarks of value-based care. Multidisciplinary oncology care pathways are essential components of value-based care and their payment metrics. Oncology pathways are evidence-based, standardized but personalizable care plans to guide cancer care.

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Atherosclerosis is a chronic disease of arteries, which constitutes the pathological basis of a series of cardiovascular diseases. The inflammatory response of vascular endothelial cells mediated by oxidized low density lipoprotein (ox-LDL) is the early behavior and main signal of atherosclerosis. In this study, the damage model of vascular endothelial cells treated with ox-LDL was used to reproduce the damage process of vascular endothelial cells in the process of atherosclerosis.

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To palliate suffering, understanding the circumstances leading to suffering and its amelioration could be helpful. Our study aimed to explore contributing and relieving factors of suffering in palliative care. Adult palliative care stage III or IV cancer in-patients were recruited from University of Malaya Medical Centre.

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Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced with the identification of various key oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalizing therapy based on the molecular genomics of the tumor. This review presents approved treatments against actionable mutations in NSCLC as well as promising targets and therapies.

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Purpose: To validate a 10-point scoring system for the prediction of successful treatment modality in patients with cesarean scar pregnancy (CSP).

Patients And Methods: Data were collected from women seen between April 1, 2018, and June 30, 2019, at the Second Affiliated Hospital of Army Medical University of China who were diagnosed with CSP and underwent evacuation, followed by uterine artery embolization (UAE) and successive laparoscopic local resection as salvage treatment if necessary. A score was computed based on clinical and ultrasonographic parameters included in a previously developed scoring system.

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Article Synopsis
  • This study investigates various patterns of suffering among adult palliative care patients at the University of Malaya Medical Centre, aiming to enhance understanding and management of suffering experiences.
  • Over a week, suffering scores were recorded three times daily for 53 patients, revealing that most experienced a downward trend in suffering, while some reported upward or stable patterns.
  • The analysis identified nine distinct patterns of suffering based on two characteristics: intensity and fluctuation, which could help improve care strategies for managing patient suffering.
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Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in brain activation induced by acupuncture. Thus, the time course of the therapeutic effects of acupuncture remains unclear.

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Most tumors are epithelial-derived, and although disruption of polarity and aberrant cellular junction formation is a poor prognosticator in human cancer, the role of polarity determinants in oncogenesis is poorly understood. Using in vivo selection, we identified a mammalian orthologue of the Drosophila polarity regulator crumbs as a gene whose loss of expression promotes tumor progression. Immortal baby mouse kidney epithelial cells selected in vivo to acquire tumorigenicity displayed dramatic repression of crumbs3 (crb3) expression associated with disruption of tight junction formation, apicobasal polarity, and contact-inhibited growth.

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Defects in apoptosis that evolve during the course of cancer progression not only provide cancer cells with intrinsic survival advantage, but also provide inherent resistance to chemotherapeutic agents. Thus, modulation of apoptosis by targeting components of the apoptotic machinery and its regulators to restore apoptotic function is a rational approach for treating cancer. With our increasing knowledge of the mechanisms of apoptosis regulation and of how apoptosis is disabled in cancer cells, numerous novel approaches targeting apoptotic pathways can now be exploited for cancer therapy.

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Article Synopsis
  • * Persistent humoral immunity and activated innate immune cells contribute to tissue remodeling and pro-angiogenic pathways, which enhance cancer risk by suppressing anti-tumor immune responses.
  • * Recent studies suggest that targeting the imbalance of immune responses, particularly the interplay between humoral and cellular immunity, could offer new strategies for cancer immunotherapy.
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Article Synopsis
  • Defective apoptosis can lead to increased tumor growth and make cancer treatment less effective.
  • The protein BIM acts as a tumor suppressor in solid tumors and influences how well tumors respond to the chemotherapy drug paclitaxel.
  • The H-ras/MAPK pathway can make tumors resistant to paclitaxel by degrading BIM, but using the proteasome inhibitor Velcade restores BIM levels and enhances the effectiveness of paclitaxel treatment.
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Genomic instability is a hallmark of cancer development and progression, and characterizing the stresses that create and the mechanisms by which cells respond to genomic perturbations is essential. Here we demonstrate that antiapoptotic BCL-2 family proteins promoted tumor formation of transformed baby mouse kidney (BMK) epithelial cells by antagonizing BAX- and BAK-dependent apoptosis. Cell death in vivo correlated with hypoxia and induction of PUMA (p53 up-regulated modulator of apoptosis).

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Objective: To study the clinical manifestation, angiographic features, and prognosis of myocardial bridge.

Methods: A retrospective analysis was made on the data of the clinical manifestation, coronary angiography, and prognosis of 35 patients with myocardial bridge, 29 males and 6 females, with an average age of 52.0 +/- 9.

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