Efficient ion transport mode and stable Li-interface induced by the introduction of HA-SiO in PVDF-based electrolytes for solid-state lithium metal batteries.

Polyvinylidene fluoride (PVDF) materials have been widely investigated as polymer matrix for solid polymer electrolytes (SPEs) due to their high dielectric constant, electroactive effect (piezo-, pyro-, and ferroelectricity), and excellent thermal stability. However, the poor interface compatibility caused by highly reactive residual solvents and unsatisfactory ionic conductivity owing to sluggish Li transport kinetics are principal bottlenecks impeding the further development of PVDF-based electrolytes. Herein, we design a PVDF-based electrolytes with the assistance of hydrophilic-amorphous silica (HA-SiO).

cGAS-like receptors drive a systemic STING-dependent host response in Drosophila.

cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. However, its exact contribution at the organismal level remains uncharacterized. Here, we use STING::GFP knockin reporter Drosophila flies to document activation of the pathway in vivo.

Transarterial chemoembolization combined with sintilimab and lenvatinib for the treatment of unresectable hepatocellular carcinoma: a retrospective study.

Background: The treatment of unresectable hepatocellular carcinoma (uHCC) challenging due to unfulfilled clinical requirements.

Objective: To evaluate the safety and efficacy of combining transarterial chemoembolization (TACE) with sintilimab and lenvatinib in the treatment of uHCC.

Methods: We retrospectively analyzed the data of patients with uHCC who were treated with a combination of TACE, sintilimab, and lenvatinib between May 2019 and December 2021 at the Chinese PLA General Hospital.

Top-Down Synthesis of N-Type PbS Quantum Dots with High Photoluminescence Quantum Yield from Microsized Pb(OH)Cl.

Synthesis of PbS quantum dots (QDs) with uniform and controllable size is of great importance in realizing functionality manipulation, as well as building advanced devices, and these QDs have been normally synthesized via "bottom-up" colloidal chemistry. However, the problems of complicated techniques and the relative high cost of the "bottom-up" methods still need to be overcome. Herein, we present a facile and cost-effective "top-down" strategy for the production of PbS QDs with controllable sizes and narrow dispersions (4.

A Modeling Framework for the Thermoforming of Carbon Fiber Reinforced Thermoplastic Composites.

A comprehensive modeling framework for the thermoforming of polymer matrix woven laminate composite was developed. Two numerical indicators, the slip path length and traction magnitude, have been identified to be positively correlated to matrix smearing and wrinkling defects. The material model has been calibrated with picture-frame experimental results, and the prediction accuracy for intra-ply shear and thickness distribution was examined with measurements of the physically formed parts.

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies.

Iodine deficiency results in elevated thyroglobulin (Tg) concentrations, with high iodine Tg being more immunogenic than low iodine Tg. The study investigated the correlation between serum iodine concentration and thyroglobulin autoantibody (TgAb) levels across diverse iodine nutritional statuses as determined by urine iodine concentration (UIC). Demographic information was collected from 1,482 participants through a questionnaire.

Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.

Background: The association between vitamin D supplementation and the risk of falls in older adults has been controversial. This systematic review and network meta-analysis aims to assess the efficacy of vitamin D, calcium, and combined supplementation in the prevention of falls.

Methods: Randomized controlled trials (RCTs) on the efficacy of vitamin D in fall prevention were systematically searched in PubMed, Embase, Cochrane Library, and Web of Science from inception to May 9, 2023.

Effects of HO on Improving the Performance of a Solid Composite Electrolyte Fabricated via an Air-Processable Technique.

Inert atmosphere is normally necessary for fabrication of solid composite electrolytes (SCEs) as a crucial part of solid-state Li-metal batteries in order to avoid undesirable reactions induced by ambient moisture. Herein, we developed an air-processable technique to fabricate SCEs by employing LiCFSO (LiOTf) as the Li salt, which was combined with LiLaZrTaO (LLZTO) as the fast Li-conductor and polyvinylidene difluoroethylene/polyvinyl acetate (PVDF/PVAC) as the polymer matrix. With the assistance of trace HO dissolved in electrolyte solution, the room-temperature Li conductivity of the obtained aSCE reached as high as 5.

Wearable Sensor-Based Residual Multifeature Fusion Shrinkage Networks for Human Activity Recognition.

Human activity recognition (HAR) based on wearable sensors has emerged as a low-cost key-enabling technology for applications such as human-computer interaction and healthcare. In wearable sensor-based HAR, deep learning is desired for extracting human active features. Due to the spatiotemporal dynamic of human activity, a special deep learning network for recognizing the temporal continuous activities of humans is required to improve the recognition accuracy for supporting advanced HAR applications.

The association between thyroid-stimulating hormone and thyroid nodules, goiter and thyroid antibody positivity.

Background: The relationship between normal thyroid-stimulating hormone (TSH) levels and thyroid disease in adults remains controversial. This study aimed to investigate the correlation between serum TSH levels, particularly those falling within the normal range, and thyroid diseases in Chinese adults, including thyroid nodules (TN), goiter (GR), and thyroid antibody positivity.

Materials And Methods: This research was a cross-sectional study conducted in an adult population in Tianjin, China.

Application and Comparison of Different Regression Models in Iodine Balance Experiment on Women of Childbearing Age and Pregnant Women.

The iodine balance experiment is a traditional approach to evaluate the physiological requirement for iodine, while the simple linear regression model (SLM) and the mixed effects model (MEM) are two primary methods used to analyze iodine balance experiments. In the present study, we aimed to compare the effects of these two regression models on the evaluation of iodine balance experiments to investigate appropriate valuation methods. By constructing SLM and MEM, zero iodine balance values (IBV) were determined, and the evaluation effects were compared.

Blueberry extracts antagonize Aβ neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus.

Background: The neuroprotective potential of blueberry (BB) extracts against Alzheimer's disease (AD) has been previously hinted at, while its exact mechanism has remained largely enigmatic.

Objective: Our study endeavored to unravel the impacts and mechanisms by which BB extracts ameliorated the learning and memory prowess of AD-afflicted mice, with a specific focus on the MEK-ERK pathway.

Methods: We employed 3-month-old APP/PS1 transgenic mice and stratified them into three distinct groups: AD+BB, AD, and control (CT).

4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L.

Psoralea corylifolia L. (P. corylifolia) has attracted increasing attention because of its potential hepatotoxicity.

Iodine Intakes of <150 μg/day or >550 μg/day are Not Recommended during Pregnancy: A Balance Study.

Background: Adequate iodine intake during pregnancy is critical for maintaining maternal and fetal thyroid function and development. There are only limited data from iodine-balance studies to inform iodine requirements during pregnancy.

Objectives: This is an iodine-balance study conducted to explore the associations among iodine intake, excretion, and retention to provide information regarding iodine requirements during pregnancy.

SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9-Mediated GSK3β/β-Catenin Signaling.

Recurrence is a challenge to survival after the initial treatment of esophageal squamous cell carcinoma (ESCC). But, its mechanism remains elusive and there are currently no biomarkers to predict postoperative recurrence. Here, the possibility of sterile alpha motif domain-containing protein 9 (SAMD9) as a predictor of postoperative recurrence of ESCC is evaluated and the molecular mechanisms by which SAMD9 promotes ESCC recurrence are elucidated.

Advances in phosphoproteomics and its application to COPD.

Introduction: Chronic obstructive pulmonary disease (COPD) was the third leading cause of global death in 2019, causing a huge economic burden to society. Therefore, it is urgent to identify specific phenotypes of COPD patients through early detection, and to promptly treat exacerbations. The field of phosphoproteomics has been a massive advancement, compelled by the developments in mass spectrometry, enrichment strategies, algorithms, and tools.

Nickel Foam Coated by Ni Nanoparticle-Decorated 3D Nanocarbons as a Freestanding Host for High-Performance Lithium-Sulfur Batteries.

Nanocarbons (NCs) consisting of carbon nanotubes (CNTs) and carbon nanofibers (CNFs) were coated on the surface of nickel foam (NF) via a chemical vapor deposition method. The CNFs formed conductive networks on NF, while the CNTs grew perpendicular to the surface of the CNFs, accompanied with the formation of Ni nanoparticles (Ni NPs) at the end of CNTs. The unique Ni-NCs-coated NF with a porous structure was applied as the three-dimensional (3D) current collector of lithium-sulfur (Li-S) batteries, which provided enough space to accommodate the electrode materials inside itself.

The simplified iodine-specific food frequency questionnaire can evaluate iodine intake in Chinese adults.

We hypothesized that an effective iodine-specific food frequency questionnaire (I-FFQ) simplification method could expand the application of the I-FFQ in evaluating long-term iodine intake. An adult I-FFQ was developed and was simplified by deleting food items with iodine contribution rates ≤0.1%, combining food items with similar species and iodine contribution rates, and calculating the iodine content of combined food by a weighted calculation method.

A new intracellular targeting motif in the cytoplasmic tail of the spike protein may act as a target to inhibit SARS-CoV-2 assembly.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a threat to global public health, underscoring the urgent need for the development of preventive and therapeutic measures. The spike (S) protein of SARS-CoV-2, which mediates receptor binding and subsequent membrane fusion to promote viral entry, is a major target for current drug development and vaccine design. The S protein comprises a large N-terminal extracellular domain, a transmembrane domain, and a short cytoplasmic tail (CT) at the C-terminus.

Application of time-reversal in electromagnetic power synthesis under distributed motion platform.

Space-time adaptive focusing is the most prominent feature of time-reversal electromagnetic waves. This paper studies the spatial power synthesis technology of distributed motion platforms based on time-reversal electromagnetic waves. Firstly, the spatial power synthesis process based on time-reversal on a distributed fixed platform is modeled.

Bioactive extracts and association with C and N in Eleutherococcus senticosus subjected to chitosan nanoparticles in contrasting light spectra.

Bioactive compounds are major reasons for the value of Eleutherococcus senticosus, which can be modified by different lighting spectra. Light-emitting diode (LED) provides lights with specific spectra which can interact with other treatments to impact plant bioactive production. Chitosan nanoparticle (CN) is a biopolymer derived from marine creatures.