Publications by authors named "Tamr B Atieh"
Biomolecules
October 2021
Article Synopsis
- DJ-1, an antioxidant protein, can repair glycation, but the specific mechanism was previously unclear; this study uses NMR and AFM to explore DJ-1's interaction with glycated αSyn.
- The findings suggest that DJ-1 binds to glycated αSyn, helps to reduce oligomer formation, and may protect against the spread of toxic aggregates in the brain, shedding light on its protective role in Parkinson's disease. *
Article Synopsis
- β-synuclein, an intrinsically disordered protein, inhibits the aggregation of α-synuclein, which is linked to Parkinson's disease, but the mechanisms behind its inhibitory effects are not fully understood.
- Researchers utilized chimeras of α-synuclein and β-synuclein to investigate which parts of the proteins contribute to α-synuclein aggregation and inhibitor functions.
- Findings reveal that the non-amyloid-β component of β-synuclein primarily drives fibril formation inhibition, while both the N- and C-terminal domains are vital for effective inhibition, suggesting that targeting multi-site inhibitory interactions could lead to new therapeutic approaches.
J Biol Chem
September 2017
Article Synopsis
- * The study investigates how changes in pH affect the fibril formation of αS and βS, revealing that lower pH levels can trigger βS fibrillation.
- * Specific glutamate residues in βS are identified as critical for its pH sensitivity, suggesting that even minor pH fluctuations in cells could influence βS aggregation and impact cellular functions related to Parkinson's disease.
