Nutritional, Antioxidant, and Functional Properties of Cameroonian Cowpea and Bambara Groundnut and Their Culinary Forms.

Background Voandzou and cowpea are two legumes commonly used in African dishes as alternative sources of proteins. The present study aimed to evaluate the effects of steaming and frying on the nutritional and functional properties of Cameroonian cowpea () and Bambara groundnut (). Methodology The nutritional values, as well as the antioxidant, alpha-amylase, and alpha-glucosidase inhibitory activities of "koki" and "beignet koki," which are the traditional steamed dish and fritters made from cowpea and Bambara groundnut, respectively, were assessed.

Epidemiology of Multidrug-Resistant Typhi and Paratyphi Isolated From Stool Culture.

Enteric fever is a significant health problem in developing countries caused by serovars Typhi and Paratyphi. Unfortunately, the burden of the disease remains high not only because of the complications related to the disease but also, especially, because of the spread of the strains of resistant to antibiotics. The aim of the present study was to evaluate the antibiotic resistance patterns of Typhi and Paratyphi clinical isolates as well as the risk factors associated with infection.

Prevalence and associated risk factors of Mycoplasma genitalium infection in women in Western Cameroon: A cross sectional study.

Background Mycoplasma genitalium is implicated in genitourinary disorders in both men and women as a sexually transmitted infection (STI). This study aimed to ascertain the prevalence of M. genitalium and identify associated risk factors among women.

Synthesis, characterization, and antibacterial activity studies of two Co(II) complexes with 2-[(E)-(3-acetyl-4-hydroxyphenyl)diazenyl]-4-(2-hydroxyphenyl)thiophene-3-carboxylic acid as a ligand.

Two new Cobalt(II) complexes 12 and 13 have been synthesized from 2-[(E)-(3-acetyl-4-hydroxyphenyl)diazenyl]-4-(2-hydroxyphenyl)thiophene-3-carboxylic acid (11) as a novel ligand. These three new compounds were characterized on the basis of their powder X-Ray Diffraction, UV-Vis, IR, NMR, elemental analysis and MS spectral data. DFT/B3LYP mode of calculations were carried out to determine some theorical parameters of the molecular structure of the ligand.

New triterpenoid saponin from the aerial part of Welw ex. Bak. (Fabaceae) and their antibacterial activities.

The chemical investigation of the aerial part of led to isolation of a new triterpenoid glycoside named Canescensoside () and four known compounds including longispinogenin-3---D-glucuronopyranoside (), -sitosterol-3---D-glucoside (), apigenin-7---D-glucopyranoside () and apigenin-7--[-L-rhamnopyranosyl-(1→3)--D-glucopyranoside] (). Structures of compounds were assigned by interpretation of their spectral data, mainly 1D and 2D NMR, HRESIMS, and by comparison with the reported data. The MeOH extract, EtOAc and -BuOH fractions as well as isolated compounds were tested for their antibacterial activities against four bacteria strains among which, two Gram-negative ( ATCC 76110 and ATCC 8739) and two Gram-positive ( ATCC 29212 and ATCC 25923) bacteria using the broth microdilution method.

Antibacterial stigmastane-type steroids and other constituents from the leaves of (Steetz) Vatke (Asteraceae).

Two new stigmastane steroids ( and ) were isolated from the methanol extract of the leaves of , together with seventeen known compounds () including one fatty acid, four triterpenoids, four steroids, one trinitropropanoyl glucoside, and seven flavonoids. The structures of compounds and were assigned based on their IR, NMR and MS data, and by comparison with literature values. The MeOH extract, its fractions and isolated compounds were subjected to antibacterial assay against two Gram-positive ( ATCC25923 and ATCC49619) and two Gram-negative ( ATCC8739 and ATCC10031) bacteria, using broth microdilution method.

Association of Biochemical and Hematological Parameters With Enteric Fever Infection at the Dschang Regional Annex Hospital, Cameroon: A Cross-Sectional Study.

Background Enteric fever is a systemic infection in humans caused by the Gram-negative bacilli serovars Typhi and Paratyphi Although the diagnosis typically involves the isolation of serovars, it is often determined based on laboratory findings and clinical observations. However, due to the wide variety and the non-specific character of clinical features, making a definitive diagnosis presents numerous challenges. Therefore, the aim of this study was to find the predictive hematological and biochemical parameters which would serve in the diagnosis, prognosis, and treatment of typhoid fever cases.

Triterpene and Steroids from A. Rich (Onagraceae) Displayed Antimicrobial Activities and Synergistic Effects with Conventional Antibiotics.

Difficulties encountered in treating drug-resistant pathogens have created a need for new therapies. Synergistic combinations of antibiotics are considered as ideal strategies in combating clinical and multidrug-resistant (MDR) infections. In this study, the antimicrobial activities of triterpenes and steroids from A.

Phytochemical Analysis, Antifungal, and Antioxidant Properties of Two Herbs ( and ) and One Tree () Species.

Phytochemicals present in medicinal plants (herbs, shrubs, and trees) are endowed with high antimicrobial and antioxidant properties. The aim of this work was to study the chemical composition, antioxidant, and antifungal activities of , and Chemical composition of the plant extracts was determined using standard methods. The antioxidant activities were performed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), nitric oxide (NO), and hydroxyl (OH) scavenging assays.

Multidrug-Resistant Causing Urinary Tract Infections among Controlled and Uncontrolled Type 2 Diabetic Patients at Laquintinie Hospital in Douala, Cameroon.

Urinary tract infections (UTIs) in patients with diabetes are a major public health problem worldwide, particularly in developing countries. This study assessed the resistance profile of and biochemical abnormalities in controlled and uncontrolled type 2 diabetic patients. A cross-sectional study was conducted at the Douala Laquintinie Hospital from January, 2020, to July, 2021, on the diabetic and nondiabetic participants.

A New Ceramide from Cissus Aralioides Baker (Vitaceae) and its Antimicrobial Activity.

Purification through repeated column chromatography over silica gel and Sephadex LH-20 of the ethanol extract of the stems of Cissus aralioides (Baker) Planch. resulted in the isolation of a new ceramide, aralioidamide A (1), along with five known compounds (2-6). Their structures were determined by the extensive analyses of their spectroscopic (1D and 2D NMR) and spectrometric data, and comparison with those reported in the literature.

Echinograciolide, a new antibacterial nor-triterpenoid and other constituents from O. Hoffm. (Asteraceae).

Antibacterial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antibacterial activity of extracts and compounds from O. Hoffm.

Two new flavone glycosides from the leaves of Oliv. (Ochnaceae).

Two new glycosylflavones, 6''--acetyl-8----galactopyranosylchrysoeriol () and 8----galactopyranosylchrysoeriol () were isolated from the methanol extract of the leaves of Oliv., along with four known compounds namely 8----galactopyranosylapigenin (), ochnaflavone (), sitosterol-3--glucopyranoside () and -mannitol (). Isolation was performed chromatographically and the structures of the purified compounds were elucidated by analyzing their spectroscopic and mass spectrometric data.

Chemotaxonomy and Antibacterial Activity of the Extracts and Chemical Constituents of Hiern. (Rubiaceae).

The use of natural products for medicinal purposes is becoming more and more common nowadays, as evidenced by the presence in plants of secondary metabolites with different potentials such as antioxidant and antibacterial properties. We evaluated in this work the antimicrobial activities of the extracts and some isolated compounds from the seeds of Hiern. (Rubiaceae), a Cameroonian medicinal plant traditionally used to cure microbial infections.

Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone.

A new diazo derivative of a pyrrolidine-2,5-dione (8) fused at position-3,4 to a dibenzobarrelene backbone has been prepared by coupling the previously reported N-arylsuccinimid (5) precursor with aryldiazonium ion of aniline. The initial step of the reaction involved the preparation of the intermediate 9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylic anhydride (3) through [4 + 2]-cycloaddition between anthracene and maleic anhydride in refluxing xylene which was then condensed with para-aminophenol to give compound 5. Compounds 5 and 8 were characterized by their physical, elemental, and spectroscopic data.

Antibacterial and Antioxidant Activities of Isolated Compounds from Leaves.

(G. &Perr.) Taub (Mimosaceae) is a large tree native to dry tropical Africa and characteristic of dry leguminous forests.

A new antimicrobial nor-friedelane-type triterpenoid and other constituents from Hook. f. (Lamiaceae).

Chemical investigation of the ethanol extract from the whole plant of led to the isolation of a new nor-triterpenoid () along with seventeen known compounds () including seven triterpenoids, nine flavonoids and one steroid. Their structures were established on the basis of 1D- and 2D-NMR, IR, and MS experiments, and by comparison of their spectroscopic data with those of similar compounds reported in the literature. The EtOH extract and some isolated triterpenoids (- and were subjected to antimicrobial assays against a panel of pathogenic microorganisms, including Gram-positive and Gram-negative bacteria, and fungi using broth microdilution method.

Antimicrobial and Antioxidant Secondary Metabolites from Chiov. (Fabaceae) and Their Mechanisms of Antibacterial Action.

The treatment of infectious diseases with antimicrobial agents continues to present problems in modern-day medicine with many studies showing significant increase in the incidence of bacterial resistance to several antibiotics. The screening of antimicrobial activity of plant extracts and natural products has shown that medicinal plants are made up of a potential source of new anti-infective agents. The aim of this study was to evaluate the antimicrobial and antioxidant activities of extracts and compounds from the whole plant Chiov.

Antibacterial and Therapeutic Potentials of the Extract against Infected Wound in a Rat Model with Its Mechanisms of Antibacterial Action.

The wound healing process is essential to reform the damaged tissue and prevent its invasion by pathogens. The present study aims at evaluating the antibacterial and therapeutic properties of the L. (Solanaceae) extract against infected wound in a rat model with its mechanisms of antibacterial action.

Methanol extract from the seeds of Persea americana displays antibacterial and wound healing activities in rat model.

Ethnopharmacological Relevance: Persea americana Miller (Lauraceae) known as "pear" in Cameroon is comestible by the fruit. The leaves of the plant are traditionally used in the treatment of microbial infections, malaria, diabetes, high blood pressure, to stimulate uterine contractions and relief painful menstruations. The leaves and stem bark are also used to cure malaria and typhoid fever.

Antibacterial, antifungal and antioxidant activities of whole plant chemical constituents of Rumex abyssinicus.

Background: Antibiotic resistance has contributed to the burden of infectious diseases both in the hospital and community setting, and represents a great threat to public health. Previous studies have revealed the role of reactive oxygen species as intermediate mediators of tissue damage, following antibiotherapies, indicating the need of associating antioxidants to these treatments. Therefore, the present work was designed to study the antibacterial, antifungal and antioxidant activities of extracts and compounds from Rumex abyssinicus Jacq.

Room Temperature Synthesis and Characterization of Novel Bi(III) Complex with 2-Amino-3- Carbomethoxy-4,5,6,7-Tetrahydrobenzo[B]Thiophene as Potential Antimicrobial Agent.

A novel bismuth(III) complex with 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) as a ligand have been synthesized. The novel complex was characterized on the basis of its IR, NMR, elemental analysis and MS spectral data. It was found that the ligand behaves as a monodentate chelating agent and bonds to the metal ion through the nitrogen atom of the amino group to form the [BiIII(ACTT)6]Cl3 complex.

Potential anti-proliferative effects of chemical constituents and hemisynthetic derivatives from ().

Background: Biological significance of is well advocated from the literature. In Cameroon, plants from this family are routinely used for the cure of liver, cancer and cardiovascular diseases. To date, no scientific investigation corresponding to the anti-cancer activity of extracts and isolated compounds of is available.

Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes.

Background: Resistance of bacteria and fungi to antibiotics is one of the biggest problems that faces public health. The present work was designated to evaluate the antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with standard antibiotics against pathogenic phenotypes. The plant extract was prepared by maceration in methanol.