Publications by authors named "Tammy P Troska"
Article Synopsis
- The polycomb repressive complex 2 (PRC2), particularly its component EZH2, is crucial for keeping certain genes turned off, and its dysregulation is linked to cancer development, especially in B-cell lymphomas.
- In mantle cell lymphoma (MCL), PRC2 components are found to be heavily upregulated, leading to enhanced cell growth and survival, despite the absence of EZH2 mutations in this subtype.
- Pharmacological inhibition of EZH2 effectively slows down MCL cell growth by disrupting the suppressive epigenetic marks it creates, suggesting that EZH2 inhibitors could be a promising treatment for MCL patients.
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by rapid disease progression. The needs for new therapeutic strategies for MCL patients call for further understanding on the molecular mechanisms of pathogenesis of MCL. Recently, long noncoding RNAs (lncRNAs) have been recognized as key regulators of gene expression and disease development, however, the role of lncRNAs in non-Hodgkin lymphoma and specifically in MCL is still unknown.
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