Reduced Nuclear Factor kappa B activation in dentate gyrus after active avoidance training.

Nuclear Factor kappa B (NF-kappaB) is a transcription factor associated with neuroplasticity and neuronal survival during injury. Although NF-kappaB has been proven to be involved in various processes of repair, there is also evidence that NF-kappaB is associated with learning and memory formation. Our laboratory has previously observed that mice lacking the NF-kappaB p50 subunit are not proficient in learning tasks associated with active avoidance training, an effective learning paradigm.

Maternal transplantation of human umbilical cord blood cells provides prenatal therapy in Sanfilippo type B mouse model.

Numerous data support passage of maternal cells into the fetus during pregnancy in both human and animal models. However, functional benefits of maternal microchimerism in utero are unknown. The current study attempted to take advantage of this route for prenatal delivery of alpha-N-acetylglucosaminidase (Naglu) enzyme into the enzyme-deficient mouse model of Sanfilippo syndrome type B (MPS III B).

Lymphopenia and spontaneous autorosette formation in SOD1 mouse model of ALS.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by motoneuron degeneration. Increasing evidence suggests immune system involvement in ALS pathogenesis but information about peripheral blood characteristics has been lacking. We evaluated hematological and morphological parameters in peripheral blood of G93A SOD1 mice.

Transplantation of human umbilical cord blood cells benefits an animal model of Sanfilippo syndrome type B.

Sanfilippo syndrome type B is caused by alpha-N-acetylglucosaminidase (Naglu) enzyme deficiency leading to an accumulation of undegraded heparan sulfate, a glycosaminoglycan (GAG). Cell therapy is a promising new treatment and human umbilical cord blood (hUCB) cell transplantation may be preferred for delivery of the missing enzyme. We investigated the ability of mononuclear hUCB cells administered into the lateral cerebral ventricle to ameliorate/prevent histopathological changes in mice modeling Sanfilippo syndrome type B.