Low-Grade Adenosquamous Carcinoma of the Breast: A Single-Center Retrospective Study and a Systematic Literature Review.

(1) Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma (MpBC), accounting for fewer than 0.05% of breast cancer cases. Unlike the typically aggressive nature of MpBCs, LGASC is an indolent tumor with an excellent prognosis.

Extended legality of curved boundary integral method.

The angular spectrum method is an efficient approach for synthesizing electromagnetic beams from planar electric field distributions. The electric field definition is restricted to a plane, which can introduce inaccuracy when applying the synthesized beam to curved surface features. The angular spectrum method can also be interpreted as a pure source method defining the field symmetrically with respect to the creation plane.

CFD modeling of CO fixation by microalgae cultivated in a lab scale photobioreactor.

The green microalga Chlorella vulgaris has been studied for efficient fixation of carbon dioxide, CO, from elevated concentrations of in-feed gas flows. In this work, a Computational Fluid Dynamics (CFD) model for algae cultivation including the dependence on CO concentration in liquid has been derived based on cultivation experiments of Chlorella vulgaris. The experiments were performed in a laboratory scale cylindrical stirred tank reactor with a range of enriched CO concentrations in-feed (0.

Postoperative bleeding complications in breast conserving surgery and the role of antithrombotic medications: retrospective analysis of 4712 operations.

Background: This study aimed to evaluate the risk and timing of postoperative bleeding complications following breast-conserving surgery (BCS), with or without axillary surgery, especially in relation to perioperative management of antithrombotic medications.

Methods: Data from all patients who underwent BCS for breast cancer between 2010 and 2022 at a single university hospital were collected. Medical records were reviewed for reoperations, unplanned admissions, and patient characteristics.

Curved boundary integral method for electromagnetic fields.

The angular spectrum method is a rigorous method to synthesize near and far-field electromagnetic beams from planar field distributions. However, this limitation of planar surfaces has restricted its applicability to beams with simple focal planes. We propose a curved boundary integral method (CBIM) to synthesize electromagnetic beams from arbitrary surfaces to address this limitation and expand the method's scope to synthesize beams from and between shaped objects.

Wavefront-modified vector beams for THz cornea spectroscopy.

Terahertz spectroscopy is a promising method to diagnose ocular diseases, where the cornea is typically imaged by Gaussian beams. However, the beam's mismatch with the cornea's spherical surface produces a 5-10 % error in analysis. We investigate cornea spectroscopy with wavefront-modified vector beams, reducing the original analysis error to less than 0.

Perceptions of Finns with chronic diseases about factors affecting their eHealth literacy: A qualitative interview study.

Objective: This study aims to describe the factors related to the individual, the system and their interaction, which can affect eHealth literacy from the perspective of people living with one or multiple chronic diseases. As digital solutions are increasingly used in healthcare, perspectives of patients with chronic diseases must be considered.

Methods: The study design was a qualitative, descriptive interview study, gathering the insights of people living in Finland with chronic disease.

Mie scattering with 3D angular spectrum method.

Mie theory is a powerful method to model electromagnetic scattering from a multilayered sphere. Usually, the incident beam is expanded to its vector spherical harmonic representation defined by beam shape coefficients, and the multilayer sphere scattering is obtained by the T-matrix method. However, obtaining the beam shape coefficients for arbitrarily shaped incident beams has limitations on source locations and requires different methods when the incident beam is defined inside or outside the computational domain or at the scatterer surface.

High Adherence of Oral Streptococcus to Polylactic Acid Might Explain Implant Infections Associated with PLA Mesh Implantation.

The aim of this study was to evaluate and compare the biofilm formation properties of common pathogens associated with implant-related infections on two different implant material types. Bacterial strains tested in this study were , , , and . Implant materials tested and compared were PLA Resorb × polymer of Poly DL-lactide (PDLLA) comprising 50% poly-L-lactic acid and 50% poly-D-lactic acid) and Ti grade 2 (tooled with a Planmeca CAD-CAM milling device).

650 GHz imaging as alignment verification for millimeter wave corneal reflectometry.

A system concept for online alignment verification of millimeter-wave, corneal reflectometry is presented. The system utilizes beam scanning to generate magnitude-only reflectivity maps of the cornea at 650 GHz and compares these images to a precomputed/measured template map to confirm/reject sufficient alignment. A system utilizing 5 off-axis parabolic mirrors, a thin film beam splitter, and 2-axis galvanometric mirror was designed, simulated, and evaluated with geometric and physical optics.

Ultrasonic scissors decrease postoperative bleeding complications in mastectomy: A retrospective multicenter cohort study on 728 patients.

Introduction: The aim of this study was to evaluate the rate of postoperative bleeding complications (primary outcome) and any other surgical complications (secondary outcome) in mastectomy between two surgical instruments, ultrasonic SonoSurg® scissors (US) and traditional electrocautery (EC).

Materials And Methods: In total 728 patients undergoing mastectomy in two adjacent university hospitals were retrospectively evaluated in terms of postoperative bleeding episodes, surgical site infections, skin flap necrosis, and any reoperations for 30 postoperative days. A propensity score matching was performed to acquire balanced groups.

Preoperative antibiotic prophylaxis in mastectomy: A retrospective comparative analysis of 1413 patients with breast cancer.

Background And Objective: The reported rate of surgical site infections (SSIs) in breast cancer surgery varies widely in previous literature. The use of antibiotic prophylaxis is controversial but recommended by several guidelines. The aim of this study was to evaluate the efficacy of routine antibiotic prophylaxis in patients with breast cancer undergoing mastectomy.

Vector spherical harmonic analysis and experimental validation of spherical shells illuminated with broadband, millimeter wave Gaussian beams: applications to corneal sensing.

Coupling to longitudinal modes of thin spherical shells, under Gaussian-beam illumination, was explored with a theoretical method based on Fourier-optics analysis and vector spherical harmonics and was scrutinized with an experimental setup. For the theory part, the illumination frequency band was fixed between 100-600 GHz and the outer spherical shell radius of curvature and thickness are 7.5 mm and 0.

Use of ambr250 to assess mucic acid production in fed-batch cultures of a marine Trichoderma sp. D-221704.

Mucic acid, a diacid with potential use in the food, cosmetic, chemical and pharmaceutical industries, can be produced by microbial conversion of D-galacturonic acid, which is abundant in pectin. Using the ambr250 bioreactor system, we found that a recently generated transformant (D-221704, formerly referred to as T2) of a marine Trichoderma species produced up to 53 g L mucic acid in glucose-limited fed-batch culture with D-galacturonic acid in the feed at pH 4, with a yield of 0.99 g mucic acid per g D-galacturonic acid consumed.

Oncological Safety of Skin-Sparing Mastectomy and Immediate Breast Reconstruction in Extensive Ductal Carcinoma In Situ.

Introduction: Skin-sparing mastectomy (SSM) with immediate breast reconstruction is the ideal treatment for interested and suitable patients with extensive ductal carcinoma in situ (DCIS). There is no guideline to indicate on how large DCIS the procedure can be performed safely. The primary target of this study was to define the oncological safety of SSM in extensive pure DCIS.

Calibration Alignment Sensitivity in Corneal Terahertz Imaging.

Improving the longitudinal modes coupling in layered spherical structure contributes significantly to corneal terahertz sensing, which plays a crucial role in the early diagnosis of cornea dystrophies. Using a steel sphere to calibrate reflection from the cornea sample assists in enhancing the resolution of longitudinal modes. The requirement and challenges toward applying the calibration sphere are introduced and addressed.

Same-day mastectomy and axillary lymph node dissection is safe for most patients with breast cancer.

Background And Objective: The aim of this study was to evaluate the safety of same-day mastectomy, with or without a sentinel node biopsy (SNB) and/or axillary lymph node dissection (ALND).

Methods: In this retrospective study, we reviewed 913 consecutive women who underwent a simple mastectomy for breast cancer between the years 2014 and 2019 and were treated either with same-day surgery (SDS) or an overnight stay (OS) regime. We reviewed all surgical complications, any unplanned return to care (RTC) and the rehospitalization rate for 30 postoperative days.

High throughput, small scale methods to characterise the growth of marine fungi.

Various marine fungi have been shown to produce interesting, bioactive compounds, but scaling up the production of these compounds can be challenging, particularly because little is generally known about how the producing organisms grow. Here we assessed the suitability of using 100-well BioScreen plates or 96-well plates incubated in a robot hotel to cultivate eight filamentous marine fungi, six sporulating and two non-sporulating, to obtain data on growth and substrate (glucose, xylose, galactose or glycerol) utilisation in a high throughput manner. All eight fungi grew in both cultivation systems, but growth was more variable and with more noise in the data in the Cytomat plate hotel than in the BioScreen.

Engineering marine fungi for conversion of D-galacturonic acid to mucic acid.

Background: Two marine fungi, a Trichoderma sp. and a Coniochaeta sp., which can grow on D-galacturonic acid and pectin, were selected as hosts to engineer for mucic acid production, assessing the suitability of marine fungi for production of platform chemicals.

Growth of marine fungi on polymeric substrates.

Background: Marine fungi are a diverse group of opportunistic and obligate organisms isolated from marine environments. These fungi are now often included in screens for novel metabolites, while less attention has been given to their production of hydrolytic enzymes. Most enzymes derived from marine microorganisms have been obtained from marine bacteria.

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis.

Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d-leucine, l-alanine, and l-phenylalanine). Using the newly sequenced S.

Production of Calcaride A by Calcarisporium sp. in Shaken Flasks and Stirred Bioreactors.

Increased interest in marine resources has led to increased screening of marine fungi for novel bioactive compounds and considerable effort is being invested in discovering these metabolites. For compound discovery, small-scale cultures are adequate, but agitated bioreactors are desirable for larger-scale production. Calcarisporium sp.

Production of scopularide A in submerged culture with Scopulariopsis brevicaulis.

Background: Marine organisms produce many novel compounds with useful biological activity, but are currently underexploited. Considerable research has been invested in the study of compounds from marine bacteria, and several groups have now recognised that marine fungi also produce an interesting range of compounds. During product discovery, these compounds are often produced only in non-agitated culture conditions, which are unfortunately not well suited for scaling up.

ERCP procedures in a Finnish community hospital: a retrospective analysis of 1207 cases.

Background And Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure with a risk of serious and life-threatening complications. The most common complications are pancreatitis, haemorrhage, perforation and cholangitis. The aim of this study was to determine indications, success rates and complications in a low-volume ERCP unit in Kanta-Häme Central Hospital (KHCH).

Passive terahertz camera for standoff security screening.

We describe the construction and performance of a passive, real-time terahertz camera based on a modular, 64-element linear array of cryogenic hotspot microbolometers. A reflective conical scanner sweeps out a 2 m x 4 m (vertical x horizontal) field of view (FOV) at a standoff range of 8 m. The focal plane array is cooled to 4 K in a closed cycle refrigerator, and the signals are detected on free-standing bridges of superconducting Nb or NbN at the feeds of broadband planar spiral antennas.