Publications by authors named "Tamlyn M Shaw"
Article Synopsis
- A novel SARS-CoV-2 was identified in China in December 2019, leading to a global pandemic, and vaccination is key to achieving immunity through antibody generation.
- To assess immunity levels, serological antibody assays are crucial; existing tests either lack quality or do not quantify immune responses effectively.
- A new rapid serological magnetic immunodetection (MID) assay was created, showing 97% sensitivity and 92% specificity, capable of accurately detecting SARS-CoV-2 antibodies in just 21 minutes using patient sera.
The fibrillar collagen scaffold of the extracellular matrix provides a structural framework for cells in tissues and regulates intercellular communication; its disregulation has been associated with tumour development and progression. Previous work has shown that expression of type I collagen, the most abundant mammalian extracellular matrix protein, is decreased in chemically or virally transformed cells. This negative regulation could be mapped to a proximal COL1A2 promoter element spanning a CME (Collagen Modulating Element) site in SV40-transformed human fibroblasts (SV-WI38) that binds an unknown repressing protein.
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