Systemic Administration of Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia.

Objective: The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE), derived fraction, and isolated compounds from leaves in a mouse model of pulmonary neutrophilia.

Methods: The CE and derived fractions, hexane, ethyl acetate, and methanol, were obtained from . leaves.

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy.

Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs.

Phenolic Compounds Isolated from Less. Promote Anti-Inflammatory and Antioxidant Effects in Mice Neutrophils () and in Mice Pleurisy Model ().

The literature shows that phenolic compounds possess important antioxidant and anti-inflammatory activities; however, the mechanism underlying these effects is not elucidated yet. The genus is used in folk medicine to treat rheumatism, respiratory diseases, and digestive problems. In this context, some phenolic compounds were isolated with high purity from Less.

A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma.

Cancer is a major public health problem around the globe. This disorder is affected by alterations in multiple physiological processes, and oxidative stress has been etiologically implicated in its pathogenesis. Glioblastoma (GBM) is considered the most common and aggressive brain tumor with poor prognosis despite recent improvements in surgical, radiation, and chemotherapy-based treatment approaches.

Anti- and cytotoxic activities of perillaldehyde epoxide synthetic positional isomers.

Leishmaniasis belongs to a complex of zoonotic disease caused by protozoa of the genus and is considered a major public health problem. Several essential oil chemical components have inhibitory effect against protozoa, including . Thus, the aim of this study was to evaluate for the first time the anti- activity of two -menthane monoterpene isomers (EPER-1: perillaldehyde 1,2-epoxide and EPER-2: perillaldehyde 8,9-epoxide) against promastigotes as well as evaluating cytotoxic effect on mononuclear peripheral blood cells.

Antidepressant Flavonoids and Their Relationship with Oxidative Stress.

Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease.

Analgesic-Like Activity of Essential Oil Constituents: An Update.

The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several diseases and promising use as compounds with analgesic-like action. Considering that pain affects a significant part of the world population and the need for the development of new analgesics, this review reports on the current studies of essential oils' chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.

Calea uniflora Less. attenuates the inflammatory response to carrageenan-induced pleurisy in mice.

Calea uniflora Less. (family Asteraceae), also named "arnica" and "erva-de-lagarto", is a native plant to the South and Southeast of Brazil. This species was used to treat rheumatism, respiratory diseases, and digestive problems in Brazilian folk medicine.

Larvicidal Activity of Essential Oil Constituents Against Malaria Vector, Anopheles gambiae (Diptera: Culicidae).

Malaria is one of the most important public health problems worldwide. This illness is controlled, mainly, by combating the vector mosquitoes using chemical insecticides, but this use has caused environmental impact and the emergence of tolerance in adult mosquitoes. Herein, we report the larvicidal activity of nine chemical constituents found in essential oils against third-instar larvae of Anopheles gambiae.

Evaluation of Antiparasitc Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone and Analogues against Trypanosoma brucei.

Considering the pressing need for new drugs to treat sleeping sickness and Nagana disease, essential oil, its principal constituent rotundifolone, and four related -menthane-type monoterpenes (two stereoisomers of limonene epoxide, perillyl alcohol, and perillyl aldehyde) were investigated for their activity against bloodstream forms of . The general cytotoxicity of the compounds was determined with human myeloid HL-60 cells. The effect of the essential oil and the monoterpenes on the growth of parasite and human cells was evaluated in cell cultures with the resazurin viability assay.

Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives.

Compounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives.

Oxime derivatives with larvicidal activity against Aedes aegypti L.

Oximes containing secondary metabolites constitute an important group of bioactive compounds and have been described and frequently updated in the literature due to their pharmacological properties. Thus, the aim of this study was to evaluate the larvicidal activity of a series of fourteen structurally related [1,4]-Benzoquinone mono-oximes on third-instar Aedes aegypti larvae and to investigate structure-activity relationships (SAR) of these compounds. Results of larvicidal assay revealed that all oximes were found to have larvicidal activity.

Antitumor activity of monoterpenes found in essential oils.

Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes.

Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy.

This study was conducted to explore the anti-inflammatory effect of Jungia sellowii (Asteraceae) using a murine model of pleurisy induced by carrageenan (Cg). This plant is used in southern Brazil to treat inflammatory diseases. J.

Anticonvulsant effects of acute treatment with cyane-carvone at repeated oral doses in epilepsy models.

Epilepsy affects about 40 million people worldwide. Many drugs block seizures, but have little effect in preventing or curing this disease. So the search for new drugs for epilepsy treatment using animal models prior to testing in humans is important.

Cyane-carvone, a synthetic derivative of carvone, inhibits inflammatory response by reducing cytokine production and oxidative stress and shows antinociceptive effect in mice.

Cyane-carvone (CC) was studied to elucidate its anti-inflammatory, antinociceptive, and antioxidant effects in Mus musculus. Anti-inflammatory (bradykinin, histamine, prostaglandin E2, serotonin, and carrageenan) and antinociceptive (acetic acid and formalin) models were utilized. Myeloperoxidase activity, interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α), and glutathione (GSH) levels were evaluated.

Larvicidal activity of Mentha x villosa Hudson essential oil, rotundifolone and derivatives.

The aim of this study was to evaluate the larvicidal activity of Mentha x villosa essential oil (MVEO) and its major constituent, rotundifolone, against larvae of Aedes aegypti. Additionally, a set of 15 analogues of the rotundifolone were evaluated to identify the molecular characteristics which contribute to the larvicidal effect. The results from the present study showed that the MVEO exhibited outstanding toxic effects against Ae.

Structural relationships and vasorelaxant activity of monoterpenes.

Background And Purpose Of The Study: The hypotensive activity of the essential oil of Mentha x villosa and its main constituent, the monoterpene rotundifolone, have been reported. Therefore, our objective was to evaluate the vasorelaxant effect of monoterpenes found in medicinal plants and establish the structure-activity relationship of rotundifolone and its structural analogues on the rat superior mesenteric artery.

Methods: Contractions of the vessels were induced with 10 μM of phenylephine (Phe) in rings with endothelium.

Anticonvulsant and antioxidant effects of cyano-carvone and its action on acetylcholinesterase activity in mice hippocampus.

The anticonvulsant effect of cyano-carvone, a monoterpene monocyclic, was investigated in epilepsy model induced by pilocarpine. Cyano-carvone at doses of 25, 50 or 75 mg/kg promoted a reduction of 16.7, 33 and 66.