[A Case of Recurrent Breast Cancer with Carcinomatous Pleurisy Successfully Treated with Paclitaxel and Bevacizumab after Radical Mastectomy].

A 61-year-old postmenopausal woman with breast cancer and carcinomatous pleurisy was successfully treated with bevacizumab and paclitaxel. In December 2008, after receiving preoperative chemotherapy consisting of q3w 4 cycles of EC (E: 90 mg/m2, C: 600 mg/m2) and 12 cycles of weekly paclitaxel (80 mg/m2), the patient underwent modified radical mastectomy with axillary lymph node dissection for right breast cancer. Pathological examination showed residual tumor cells and lymph node metastasis (pT4bN2M0, Stage III b).

Breakdown of time-temperature superposition in a bead-spring polymer melt near the glass transition temperature.

The breakdown of the time−temperature superposition (TTS) near its glass transition temperature (T(g)) in simple bead−spring polymer melts with and without the chain angle potential was numerically investigated. The stress relaxation modulus at different temperatures G(t,T) was calculated by the Green−Kubo relation. The TTS of G (t,T) of bead−spring polymer melts worked well at temperatures sufficiently higher than its T(g).

Oxygenative Cleavage of Chlorocatechols with Molecular Oxygen Catalyzed by Non-Heme Iron(III) Complexes and Its Relevance to Chlorocatechol Dioxygenases.

The degradation of halogenated arenes, which are considered as hazardous compounds from a toxicological and environmental point of view, can be effected by non-heme iron enzymes such as chlorocatechol dioxygenases. In principle, this process of biological oxygenation mimics the reaction of the iron complex shown below [Eq. (a); Py=2-pyridyl].