Publications by authors named "Tamilselvan Natrajan"
Metallic nanoparticles (MNPs) have been widely used for diagnostic and therapeutic purposes in clinical practice. A number of MNP formulations are being investigated in clinical trials for various applications. This increase in the use of NPs results in higher exposure to humans, leading to toxicity issues.
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- The study focuses on creating chitosan nanoparticles (CS-NPs) loaded with gemcitabine and capped with folic acid and silver nanoparticles, aimed at improving cancer treatment through targeted drug delivery.
- Characterization techniques such as dynamic light scattering and transmission electron microscopy confirmed the size and properties of the nanoparticles, which were influenced by their compositions and conditions.
- In vitro testing showed that the CS-NPs effectively released the drug in lower pH environments and had higher cytotoxicity on human breast cancer cells compared to neutral pH levels, indicating potential for site-specific cancer therapy.