Publications by authors named "Tamilselvan Natarajan"
Article Synopsis
- Irbesartan (IRB) is classified as a BCS class II drug with poor water solubility, making its absorption dependent on how quickly it can dissolve.
- In this study, researchers enhanced IRB's solubility and dissolution rate by creating nanocrystals using surfactants Pluronic® F127 and F68 through techniques like high shear homogenisation and ultra-probe sonication.
- The resulting nanocrystals exhibited significantly improved solubility and dissolution rates compared to the original drug, with the F127 formulation performing better than F68, demonstrating a practical method for enhancing drug delivery for poorly soluble medications.
Poly (ɛ-caprolactone) nanoparticles of carboplatin: Preparation, characterization and in vitro cytotoxicity evaluation in U-87 MG cell lines.
Vamshikrishna Karanam Gregory Marslin Balakumar Krishnamoorthy Vijayaraghavan Chellan Karthik Siram Tamilselvan Natarajan
Colloids Surf B Biointerfaces
June 2015
Article Synopsis
- Carboplatin, a platinum-based chemotherapy drug, has limited cellular uptake which necessitates higher doses leading to harmful side effects like hematologic toxicity.
- Researchers developed carboplatin-loaded nanoparticles using the biodegradable polymer poly (ɛ-caprolactone) (PCL) to enhance drug uptake and reduce side effects.
- The nanoparticles showed effective cytotoxicity against human glioma cells and no hemolytic activity in rat blood cells, suggesting that this new delivery method could improve cancer treatment outcomes while minimizing adverse effects.
Article Synopsis
- The main goal of the research is to effectively deliver diethylcarbamazine citrate (DEC) to the lymphatic system while improving its retention time.
- Solid lipid nanoparticles (SLNs) were created using various excipients and evaluated for their characteristics, such as size and drug release efficiency.
- Results showed that SLNs can enhance drug delivery to the lymphatics, achieving a maximum entrapment efficiency of 68.63% and a complete drug release in about 150 minutes.