Publications by authors named "Tamiko Nozaki"
Article Synopsis
- Peptides are useful for targeting proteins but face challenges like low membrane permeability and instability inside cells.
- Researchers developed a new fusion protein called PLIED, which uses a peptide to target proteins of interest and link them to small molecules that can easily enter cells.
- This method allows for precise modifications of specific protein residues, demonstrated by acetylating MDM2 and histone proteins, thereby enhancing the capabilities of chemical biology tools for cellular applications.
Life emerges from complicated and sophisticated chemical networks comprising numerous biomolecules (e.g., nucleic acids, proteins, sugars, and lipids) and chemical reactions catalyzed by enzymes.
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