Publications by authors named "Tami Sengoku"
Introduction: The insufficient quantity and quality of clinical epidemiological evidence in the field of rare diseases have posed methodological challenges to develop clinical practice guidelines (CPGs). Guideline development groups struggle to provide patients and their families with beneficial guidance, such as that for medical care and in complex circumstances. Motivated by the challenges, we focused on information on resources for supporting the daily and social life to improve the CPGs for users.
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- The Japanese government launched a health management support program in 2018 aimed at public assistance recipients (PAR) with type 2 diabetes (T2D), recognizing the role of social determinants in health, but data on T2D prevalence among this group were scarce.
- A study was conducted comparing T2D prevalence among PAR and health insurance enrollees (HIE) using health insurance claims, assessing differences by age, sex, and region.
- Results showed that T2D prevalence was higher in PAR (7.7%) compared to HIE (4.1% for outpatients), with significant regional variations, indicating a need for targeted prevention strategies based on location.
Since 2011, pharmaceutical companies in Japan have been required to issue two types of documents regarding severe adverse drug reactions reported post-marketing, namely the Rapid Safety Communication Materials for Patients and the Related Materials. However, the adequacy of these documents has not yet been systematically assessed. The aim of this study was to evaluate the adequacy of these two types of materials.
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- This updated version can be found via a link provided at the beginning of the paper.
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- - This study focused on pregnant women using antiepileptic drugs and their intake of folic acid, revealing that 83.3% had inadequate levels of folic acid consumption.
- - Participants were divided into two groups based on when they began folic acid supplementation, with various factors like younger age and unplanned pregnancies contributing to inadequate intake.
- - The findings suggest that planned pregnancies significantly influence folic acid intake, highlighting the need for healthcare professionals to educate women about the importance of folic acid and planned pregnancies when using antiepileptic medications.
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- Whole-body cancer screening using FDG-PET and other imaging techniques was evaluated for its effectiveness in detecting tumors in asymptomatic individuals in Osaka, Japan.
- Out of 1,762 participants, 33 were found to have primary cancers, with the screening program identifying 28 of these, resulting in a sensitivity of 84.8% and specificity of 86.8%.
- While the screening method shows reasonable accuracy, there are notable instances of false negatives and positives, emphasizing the need for clear communication about its limitations to participants.
The positioning or selection of a region of interest (ROI) is an essential step for the quantification of brain images. However, so long as the ROIs were manually selected, results obtained fluctuated considerably with subtle changes in their positioning. To perform an ROI analysis of the brain with improved objectivity and excellent reproducibility, we recently established fully automated ROI-based analysis software for the brain, the so-called 3DSRT and the FineSRT.
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