Publications by authors named "Tamer A Elwaie"

The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, and therefore represents a promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with improved pharmacology and potency may prove useful in the development of Th17-mediated adaptive immune responses. Herein, we report on in vitro and in silico investigations of specific Mincle ligand-receptor interactions required for the effective receptor engagement and activation of Th17-polarizing cytokines.

View Article and Find Full Text PDF

Twenty compounds of 6-nitro-4-substituted quinazolines were synthesized. The new derivatives were evaluated for their epidermal growth factor receptor (EGFR) inhibitory activity. The most potent derivatives were assessed for their cytotoxicity against colon cancer and lung cancer cells, in addition to normal fibroblast cells.

View Article and Find Full Text PDF

The integration of molecular modelling simulation and electrochemical sensors is of high interest. Herein, for the first time, a portable solid-contact potentiometric electrode was designed for the sensitive determination of mirabegron (MIR) in human plasma and pharmaceutical formulation. A two-step optimization protocol was investigated for the fabrication of an ion on sensing polymeric membrane.

View Article and Find Full Text PDF

Novel 5-deazaflavins were designed as potential anticancer candidates. Compounds and demonstrated high cytotoxicity against MCF-7 cell line with IC of 0.5-190nM.

View Article and Find Full Text PDF

HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with aggressive clinical outcomes; thus, herein we present structural optimization for HER2-selective targeting. HER2 profiling of the developed derivatives demonstrated potent and selective inhibitions (IC: 5.4-12 nM) compared to lapatinib (IC: 95.

View Article and Find Full Text PDF