Publications by authors named "Tameille Valentine"
Article Synopsis
- Chemotherapy-induced neuropathic pain (CINP) is a significant issue for pediatric cancer survivors, and current pain treatments are not effective due to limited understanding of CINP mechanisms.
- This study explores how cisplatin leads to neuroinflammation and increased pain sensitivity through nerve growth factor (NGF) interactions, particularly focusing on macrophage activity in the dorsal root ganglia (DRG).
- The research findings suggest that targeting the NGF-TrkA signaling pathway in macrophages may offer new pain relief strategies for adults who survived childhood cancer.
Cisplatin-based chemotherapy is a common treatment for paediatric cancer. Unfortunately, cisplatin treatment causes neuropathic pain, a highly prevalent adverse health related complication in adult childhood cancer survivors. Due to minimal understanding of this condition, there are currently no condition tailored analgesics available.
View Article and Find Full Text PDFChemotherapy causes sensory disturbances in cancer patients that results in neuropathies and pain. As cancer survivorships has dramatically increased over the past 10 years, pain management of these patients is becoming clinically more important. Current analgesic strategies are mainly ineffective and long-term use is associated with severe side effects.
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