Publications by authors named "Tamas Pandics"

The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site.

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Background: Increased lung-cancer risks for low socioeconomic status (SES) groups are only partially attributable to smoking habits. Little effort has been made to investigate the persistent risks related to low SES by quantification of potential biases.

Methods: Based on 12 case-control studies, including 18 centers of the international SYNERGY project (16,550 cases, 20,147 controls), we estimated controlled direct effects (CDE) of SES on lung cancer via multiple logistic regression, adjusted for age, study center, and smoking habits, and stratified by sex.

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Article Synopsis
  • The study assessed how different dimensions of the quantitative job-exposure matrix (SYN-JEM) impact the correlation between silica exposure and lung cancer risk, using data from 16,901 lung cancer cases and 20,965 controls from global studies.
  • The analysis revealed that including all dimensions of SYN-JEM resulted in the best fit for predicting lung cancer odds, while omitting job-specific estimates led to a poor model fit.
  • The findings suggest that to accurately model the exposure-response relationship between silica and lung cancer, it’s crucial to use all relevant factors, including job specifics, time, and region in the analysis.
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Background: While much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents.

Objectives: We investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e.

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A risk-based approach is recognised worldwide as the most reliable means for the provision of safe drinking water. Efficient implementation of the water safety plan (WSP) approach, recommended by the World Health Organization (WHO), is facilitated by an auditing framework. In Hungary, development of WSPs is a legal obligation for water suppliers.

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Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. We aimed to examine the relationship between occupational benzene exposure and lung cancer. Subjects from 14 case-control studies across Europe and Canada were pooled.

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The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases.

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(motivation): Wastewater-based epidemiology (WBE) has emerged as a promising approach for monitoring the COVID-19 pandemic, since the measurement process is cost-effective and is exposed to fewer potential errors compared to other indicators like hospitalization data or the number of detected cases. Consequently, WBE was gradually becoming a key tool for epidemic surveillance and often the most reliable data source, as the intensity of clinical testing for COVID-19 drastically decreased by the third year of the pandemic. Recent results suggests that the model-based fusion of wastewater measurements with clinical data and other indicators is essential in future epidemic surveillance.

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Wastewater-based epidemiology (WBE) is a recognised tool for tracking community transmission of COVID-19. From the second half of 2020, the emergence of new, highly infective, more pathogenic or vaccine-escape SARS-CoV-2 variants is the major public health concern. Variant analysis in sewage might assist the early detection of new mutations.

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There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects.

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Background: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project.

Methods: We pooled 14 case-control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada.

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Article Synopsis
  • The study analyzed data from the INHANCE consortium to compare the effects of cigarette smoking and alcohol consumption on head and neck cancer risk in less developed and more developed countries.
  • It found that the risk profiles associated with smoking and alcohol use vary between these country types, with specific cancers showing different patterns of risk.
  • The research highlights how factors like industrialization and economic development influence the relationship between lifestyle habits (smoking and drinking) and head and neck cancer incidence.
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Wastewater based epidemiology is a potential early warning tool for the detection of COVID-19 outbreak. Sewage surveillance for SARS-CoV-2 RNA was introduced in Hungary after the successful containment of the first wave of the pandemic to forecast the resurge of infections. Three wastewater treatment plants servicing the entire population (1.

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Article Synopsis
  • The study explored how general job demands might increase the risk of lung cancer and their relationship with occupational prestige among workers.
  • Researchers analyzed data from 13 case-control studies involving over 30,000 men and 7,300 women, assessing physical and psychosocial job demands as risk factors.
  • Findings revealed that high physical job demands significantly raised lung cancer risks for both men and women, while psychosocial demands had a weaker association, especially regarding occupational prestige in men.
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Objectives: We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project.

Methods: Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters).

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Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes. We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations. We used a quantitative EC job-exposure matrix for exposure assessment.

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While disinfection of swimming pools is indispensable for microbiological safety, it may lead to the formation of disinfection by-products. Most studies agree that inhalation exposure is the predominant pathway of the associated health risks, but assumptions are based on concentrations measured in water and evaporation models. Pool water and air were sampled in 19 swimming pools.

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Uranium and other natural radionuclides are common components in groundwater, but they are not routinely measured. In drinking water their total activity is screened, but in the evaluation of the measured values usually the aquifer material is only considered. However, the occurrence of radionuclides in groundwater is strongly affected by flow systems and their geochemical characteristics.

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Intake of acetaldehyde in alcoholic beverages, in central Europe, might explain the high rate of alcohol-related diseases in these countries. We measured the acetaldehyde level in 30 samples of home-made spirits and 12 samples of industry-made spirits from four central European countries, including 35 fruit-based and five grain-based spirits. Acetaldehyde was detected in all fruit-based spirits and in none of the grain-based spirits.

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Article Synopsis
  • - Climate change is linked to an increase in waterborne diseases due to heavy rainfall leading to microbiological contamination of water supplies, making it tough to connect rainfall events with human illness.
  • - In Miskolc, Hungary, excessive rainfall caused significant karstic water flow and flooding, which contaminated the local water source; multiple potential contamination sources were noted in the protective area.
  • - The water supplier was unprepared for the outbreak risk, prompting public health interventions to ensure safe drinking water and emphasizing the need for better preparedness against extreme weather events to safeguard water sources.
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Aim: To investigate the effect of acute insulin administration on the subcellular localization of Na(+)/K(+)-ATPase isoforms in cardiac muscle of healthy and streptozotocin-induced diabetic rats.

Methods: Membrane fractions were isolated with subcellular fractionation and with cell surface biotinylation technique. Na(+)/K(+)-ATPase subunit isoforms were analysed with ouabain binding assay and Western blotting.

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Nanomaterials are getting rapidly developing practical applications, beside many others also in the clinical practice. Their beneficial attributes make the use of the nanostructures a large improvement in effective therapy as coating of implants, bone replacement materials, coating of active substances, nano-sized liposomes to achieve better pharmacologic qualities. Beside new beneficial chemical qualities originating from their size, due to the use of nanomaterials also adverse health effects may occur.

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In the last two decades extensive study has been carried out on the isolation, identification and biosynthesis of the "endogenous digitalis-like compounds" whose physiological and pathophysiological functions are only starting to be understood. Besides ouabain (strophanthin) and digoxin, four further endogenous cardiac glycosides were isolated and identified so far. These compounds are found in almost all mammalian tissues, including blood plasma and urine, but with the highest concentrations in the adrenal gland, pituitary and hypothalamus.

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