Background activity and visual responsiveness of caudate nucleus neurons in halothane anesthetized and in awake, behaving cats.

This study focuses on the important question whether brain activity recorded from anesthetized, paralyzed animals is comparable to that recorded from awake, behaving ones. We compared neuronal activity recorded from the caudate nucleus (CN) of two halothane-anesthetized, paralyzed and two awake, behaving cats. In both models, extracellular recordings were made from the CN during static and dynamic visual stimulation.

Activity of Caudate Nucleus Neurons in a Visual Fixation Paradigm in Behaving Cats.

Beside its motor functions, the caudate nucleus (CN), the main input structure of the basal ganglia, is also sensitive to various sensory modalities. The goal of the present study was to investigate the effects of visual stimulation on the CN by using a behaving, head-restrained, eye movement-controlled feline model developed recently for this purpose. Extracellular multielectrode recordings were made from the CN of two cats in a visual fixation paradigm applying static and dynamic stimuli.

A new, behaving, head restrained, eye movement-controlled feline model for chronic visual electrophysiological recordings.

Background: Anesthetized, paralyzed domestic cats are often used as model organisms in visual neurophysiology. However, in the last few decades, behaving animal models have gathered ground in neurophysiology, due to their advantages over anesthetized, paralyzed models.

New Method: In the present study a new, behaving, awake feline model is described, which is suitable for chronic visual electrophysiological recordings.