Comprehensive Characterization of Phytochemical Composition, Membrane Permeability, and Antiproliferative Activity of Polyphenols.

The aim of our study was the detailed polyphenol profiling of and the characterization of the membrane permeability and antiproliferative properties of its main phenolics. A total of 161 compounds were tentatively identified in bark, leaf, and pericarp extracts by ultrahigh-performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HR-MS/MS). Eight compounds including myricetin-3--rhamnoside (), quercetin-3--rhamnoside (), quercetin-3--xyloside (), juglone (), 1,2,3,4-tetrahydro-7,8-dihydroxy-4-oxonaphthalen-1-yl-6--galloyl-glucoside (), ellagic acid (), gallic acid (), and ethyl gallate () were isolated from pericarp.