An ultrasonic method (20 kHz) is introduced to activate pristine ibuprofen organic molecular crystals via complexation with silver in nitrogen-doped oxidized graphene nanoplatforms (∼50 nm). Ultrasonic complexation occurs in a single-step procedure through the binding of the carboxylic groups with Ag and H-bond formation, involving noncovalent π → π transitions in the altered phenyl ring and π → π in ibuprofen occurring between the phenyl ring and C-O bonds as a result of interaction with hydroxyl radicals. The ibuprofen-silver complex in ≪NrGO≫ exhibits a ∼42 times higher acceleration rate than free ibuprofen of the charge transfer between hexacyanoferrate and thiosulfate ions.
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