Treatment goals in ANCA-associated vasculitis: defining success in a new era.

Health-related quality of life is a key contributor to overall well-being, and this is becoming an increasingly prominent factor when making therapeutic choices in the management of ANCA-associated vasculitis (AAV). Progress in available therapeutic strategies for AAV has resulted in this historically acute disease with a potentially fatal short-term outcome, becoming a relapsing-remitting chronic disorder. This new perspective on AAV means that patient survival should no longer be considered as the only major treatment target.

Patterns of chronic and transient hyperkalaemia and clinically important outcomes in patients with chronic kidney disease.

Background: Whether hyperkalaemia in CKD is chronic or transient, and whether this has different outcome implications, is not known.

Methods: This was an observational study of adults with CKD G3-5 from Stockholm, Sweden 2006-11. We examined individual trajectories of potassium from all measurements obtained through routine outpatient care.