Publications by authors named "Tamara Pflantz"
J Exp Clin Cancer Res
October 2021
Article Synopsis
- * The study examined the effects of a cytosine analogue called CNDAC, thought to inhibit SAMHD1, across various leukaemia cell lines and patient samples, using techniques like CRISPR and RNA interference to manipulate SAMHD1 levels.
- * Contrary to expectations, CNDAC actually faced resistance from SAMHD1, and its depletion led to higher levels of CNDAC's active form, which increased its effectiveness; resistance was further linked to a loss of a key kinase, DCK, that is essential for
