Preliminary comparison of the performance of the National Library of Medicine's systematic review publication type and the sensitive clinical queries filter for systematic reviews in PubMed.

Objective: The National Library of Medicine (NLM) inaugurated a "publication type" concept to facilitate searches for systematic reviews (SRs). On the other hand, clinical queries (CQs) are validated search strategies designed to retrieve scientifically sound, clinically relevant original and review articles from biomedical literature databases. We compared the retrieval performance of the SR publication type (SR[pt]) against the most sensitive CQ for systematic review articles (CQrs) in PubMed.

Development and validation of study filters for identifying controlled non-randomized studies in PubMed and Ovid MEDLINE.

A retrospective analysis published by the German Institute for Quality and Efficiency in Health Care (IQWiG) in 2018 concluded that no filter for non-randomized studies (NRS) achieved sufficient sensitivity (≥92%), a precondition for comprehensive information retrieval. New NRS filters are therefore required, taking into account the challenges related to this study type. Our evaluation focused on the development of study filters for NRS with a control group ("controlled NRS"), as this study type allows the calculation of an effect size.

Improving medication adherence in patients with cardiovascular disease: a systematic review.

Objective: To evaluate and compare the effect of interventions for improving adherence to medications for atherosclerotic cardiovascular disease (ASCVD) secondary prevention.

Methods: We extracted eligible trials from a 2014 Cochrane systematic review on adherence for any condition. We updated the search from CENTRAL, Medline, Embase, PsycINFO, CINAHL, Sociological Abstracts and trial registers through November 2016.

The efficiency of database searches for creating systematic reviews was improved by search filters.

Objectives: To compare Clinical Queries (CQs) for randomized trials of therapy 'methods' and 'NOT' limits search filters with Cochrane methods filters.

Study Design And Setting: Analytic survey of Cochrane reviews as the reference standard for retrieving studies included in the reviews ("included studies [ISs]"). The sensitivity and precision of Cochrane content terms + Cochrane methods terms were compared in MEDLINE and Embase with Cochrane content terms + CQs maximally sensitive filter for therapy studies, without and with additional 'NOT' limits (CQ-S [CQ sensitive]; CQ-S + limits) and a balanced filter without and with additional NOT limits (CQ-B [CQ balanced]; CQ-B + limits).

Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol.

Background: Individual pharmacokinetic assessment is a critical component of tailored prophylaxis for hemophilia patients. Population pharmacokinetics allows using individual sparse data, thus simplifying individual pharmacokinetic studies. Implementing population pharmacokinetics capacity for the hemophilia community is beyond individual reach and requires a system effort.