Publications by authors named "Tamara Matheis"
Article Synopsis
- Healthy individuals can generally detect biological motion using few moving points, influenced by internal models linked to their movement skills.
- The study aimed to assess whether people with symptomatic Huntington's disease (HD) struggle with perceiving movements compared to healthy individuals.
- Results indicated that those with HD showed reduced accuracy in identifying movements, particularly struggling with stair climbing motions, and did not exhibit performance improvement over time like their healthy counterparts.
Background: To increase the reliability of translating preclinical findings to humans, large animal models, such as the transgenic (tg) Libechov minipig, were established. As minipigs possess high genetic homology with humans and have similarities in anatomy, physiology and metabolism to humans, they are considered for studying neurodegenerative diseases longitudinally. Recently, sleep abnormalities and changes in circadian rhythm in Huntington's disease (HD) patients were acknowledged to present one of the early symptoms in HD.
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- Large animal models like transgenic Huntington disease minipigs have been suggested to enhance the reliability of preclinical studies due to their genetic similarity and brain structure to humans.
- The study aimed to determine if vocalization can be used to identify and differentiate transgenic Huntington disease minipigs from wildtype counterparts, focusing on behavioral assessments.
- Results showed that vocalization can effectively indicate differences between tgHD and wt minipigs, providing a valuable non-invasive method to monitor disease progression and phenotypic changes over time.
Background: Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with motor, cognitive, behavioral and metabolic symptoms. HD patients exhibit an altered response to stress which is reflected in changes of cortisol levels. Large animal models of HD such as the Libechov minipig are currently explored in preclinical studies to improve translational reliability and assessing behavior is of interest.
View Article and Find Full Text PDFBackground: Large animal models of Huntington's disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers opportunities particularly for disease modifying approaches, but also challenges. The transgenic (tg) HD minipig model assessed in this study exhibits a high genetic homology with humans, similar body weight, and comparable brain structures.
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