Mechanism of Fumonisin Self-Resistance: Contains Four Fumonisin B-Insensitive-Ceramide Synthases.

produces fumonisins, which are mycotoxins inhibiting sphingolipid biosynthesis in humans, animals, and other eukaryotes. Fumonisins are presumed virulence factors of plant pathogens, but may also play a role in interactions between competing fungi. We observed higher resistance to added fumonisin B (FB) in fumonisin-producing than in nonproducing , and likewise between isolates of and differing in production of sphinganine-analog toxins.

Development of a fumonisin-sensitive indicator strain and utilization for activity testing of candidate detoxification genes.

Fumonisins can cause diseases in animals and humans consuming -contaminated food or feed. The search for microbes capable of fumonisin degradation, or for enzymes that can detoxify fumonisins, currently relies primarily on chemical detection methods. Our constructed fumonisin B1-sensitive yeast strain can be used to phenotypically detect detoxification activity and should be useful in screening for novel fumonisin resistance genes and to elucidate fumonisin metabolism and resistance mechanisms in fungi and plants, and thereby, in the long term, help to mitigate the threat of fumonisins in feed and food.

Fullerol C(OH) Nanoparticles and Drought Impact on Wheat ( L.) during Growth and Infection with .

Fullerol C(OH) nanoparticles (FNP)-wheat- interaction outcome is more complicated in the presence of drought. This study sheds light on how the presence of FNP affects food and feed safety from the perspective of mycotoxin contamination. The study aims to determine the influence of FNP at environmentally plausible concentrations on wheat growth under drought stress and on the aggressiveness of during wheat germination, as well as the influence of FNP on the secondary metabolite profile during the inappropriate wheat storage.

Fullerol C(OH) Nanoparticles Affect Secondary Metabolite Profile of Important Foodborne Mycotoxigenic Fungi In Vitro.

Despite the efforts to control mycotoxin contamination worldwide, extensive contamination has been reported to occur in food and feed. The contamination is even more intense due to climate changes and different stressors. This study examined the impact of fullerol C(OH) nanoparticles (FNP) (at 0, 1, 10, 100, and 1000 ng mL) on the secondary metabolite profile of the most relevant foodborne mycotoxigenic fungi from genera , , and during growth in vitro.