Publications by authors named "Tamara Goebel"
On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity.
Biochim Biophys Acta Mol Cell Biol Lipids
March 2022
Neutrophils are key players in inflammation initiation and resolution. Little attention has been paid to the detailed biosynthesis of specialized pro-resolving mediators (SPM) in these cells. We investigated SPM formation in human polymorphonuclear leukocytes (PMNL), in broken PMNL preparations and recombinant human 5-lipoxygenase (5-LO) supplemented with the SPM precursor lipids 15-Hydroxyeicosatetraenoic acid (15-HETE), 18-Hydroxyeicosapentaenoic acid (18-HEPE) or 17-Hydroxydocosahexaenoic acid (17-HDHA).
View Article and Find Full Text PDFThyroid hormones (THs) operate numerous physiological processes through modulation of the nuclear thyroid hormone receptors and several other proteins. We report direct activation of the nuclear peroxisome proliferator-activated receptor gamma (PPARγ) and retinoid X receptor (RXR) by classical and nonclassical THs as another molecular activity of THs. The T4 metabolite TETRAC was the most active TH on PPARγ with nanomolar potency and binding affinity.
View Article and Find Full Text PDFGout is the most common arthritic disease in human but was long neglected and therapeutic options are not satisfying. However, with the recent approval of the urate transporter inhibitor lesinurad, gout treatment has experienced a major innovation. Here we show that lesinurad possesses considerable modulatory potency on peroxisome proliferator-activated receptor γ (PPARγ).
View Article and Find Full Text PDFArticle Synopsis
- - Multitarget design can create small molecules that are more effective and safer for treating complex chronic inflammatory diseases, which often require multiple treatments.
- - Researchers made a modified version of zafirlukast, a cysteinyl-leukotriene receptor antagonist, that also blocks an enzyme called soluble epoxide hydrolase and activates another receptor known as PPAR-γ.
- - This new "triple modulator" shows strong anti-inflammatory effects in living organisms, demonstrating the promise of drugs that can target multiple pathways simultaneously.
Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health burden with alarming incidence, but there is no satisfying pharmacological therapy to date. Considering the disease's multifactorial nature, modulation of multiple targets might provide superior therapeutic efficacy.
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