Publications by authors named "Tamara Allada"
J Biol Chem
November 2024
Article Synopsis
- - Niemann-Pick type C (NPC) disease results from mutations in NPC1 or NPC2 genes, leading to the accumulation of cholesterol in late endosomes/lysosomes, and researchers are exploring LBPA (lysobisphosphatidic acid) as a therapeutic agent to reduce this accumulation.
- - Studies indicate that different stereoisomers of LBPA are effective in reducing cholesterol levels in NPC1-deficient human fibroblast cells, with the presence of an 18:1 acyl chain being particularly significant for enhancing cholesterol clearance.
- - Further experiments suggest that while phosphatidylglycerol (PG) can also reduce cholesterol, it does not convert to LBPA effectively, highlighting that LBPA itself is essential for promoting cholesterol
