Publications by authors named "Tamara Al-Dihaissy"
Article Synopsis
- The study investigates the effects of AFC5261, a selective P2X7 receptor antagonist, on cancer-induced bone pain in rats, given the conflicting results from previous research on P2X7R inhibition.
- Acute treatment with a high dose of AFC5261 showed no beneficial effects on pain-related behaviors, while morphine was effective in improving limb use and weight-bearing.
- Chronic administration of AFC5261 at a higher dose worsened pain-related behaviors without affecting bone degradation or tumor progression, suggesting long-term inhibition may increase cancer-induced bone pain.
An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.
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