Publications by authors named "Tamara A Vico"
Background And Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol homeostasis by regulating low-density lipoprotein (LDL) receptor levels. Despite its known effects on cholesterol metabolism, the role of PCSK9 in cardiac function, especially post-myocardial infarction (MI), remains unclear. This study investigates the impact of PCSK9 on heart function post-MI and evaluates the effects of PCSK9 inhibition via Alirocumab.
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- Clonal hematopoiesis of indeterminate potential (CHIP) is linked to increased risks for leukemia and cardiovascular diseases due to the presence of mutated myeloid cells; however, their specific behavior in cardiovascular tissues is not fully understood.
- The study involved patients undergoing cardiovascular surgeries, where researchers analyzed blood and tissue samples to identify CHIP mutation carriers and assess the characteristics of myeloid and lymphoid cells using advanced genetic techniques.
- Results showed that although CHIP-mutated myeloid cells did not accumulate more in cardiovascular tissues compared to non-mutated cells, they exhibited a more proinflammatory and disease-prone gene profile.
Article Synopsis
- Atherosclerosis is a chronic inflammatory disease driven by monocytes and macrophages, but there's limited understanding of how these cells' gene expression changes over time and space during the disease progression.
- The study used apolipoprotein E-deficient mice on a high cholesterol diet to investigate gene expression in aortic macrophages, peritoneal macrophages, and circulating monocytes at different stages of atherosclerosis, utilizing RNA sequencing techniques.
- Findings revealed that there was surprisingly low overlap in gene regulation among the three cell types, highlighting that aortic macrophages were most active during the initial stages of atheroma formation, and identified the gene Gpnmb as a key factor correlated with disease progression.
Mitochondria play an essential role in inflammatory processes such as sepsis or endotoxemia, contributing to organ-cellular redox metabolism, emerging as the energy hub of the cell, and as an important center of action of second messengers. In this work, we aimed to elucidate the energy state, redox balance, and mitochondrial remodeling status in cerebral cortex in an experimental model of endotoxemia. Female Sprague-Dawley rats were subjected to a single dose of LPS (ip 8 mg kg body weight) for 6 h.
View Article and Find Full Text PDFMitophagy and zymophagy are selective autophagy pathways early induced in acute pancreatitis that may explain the mild, auto limited, and more frequent clinical presentation of this disease. Adequate mitochondrial bioenergetics is necessary for cellular restoration mechanisms that are triggered during the mild disease. However, mitochondria and zymogen contents are direct targets of damage in acute pancreatitis.
View Article and Find Full Text PDFThere is current awareness about the central role of mitochondrial dysfunction in the development of cardiac dysfunction in systemic inflammatory syndromes, especially in sepsis and endotoxemia. The aim of this work was to elucidate the mechanism that governs the link between the severity of the systemic inflammatory insult and mitochondrial function, analysing the consequences on heart function, particularly in cardiac contractile state. Female Sprague-Dawley rats were subjected to low-grade endotoxemia (i.
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