Publications by authors named "Tamar Thurm"

Article Synopsis
  • - This study explored how the processing level of food affects disease activity in inflammatory bowel disease (IBD) patients, analyzing dietary patterns and their correlation with clinical outcomes.
  • - Researchers found that higher intake of unprocessed/minimally processed foods was linked to lower disease activity, while high consumption of ultra-processed foods was associated with increased disease activity.
  • - The results suggest that moderating processed food intake could influence IBD outcomes, indicating a need for further prospective studies to validate these findings.
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  • A study was conducted to compare two preparation protocols for patients with Crohn's disease who ingested a patency capsule (PC) to assess its effectiveness in reducing failed PC rates.
  • The pro-motility group, which followed a specific diet and took medication, showed a significantly lower failed PC rate (12.0%) compared to the control group (24.7%).
  • Findings suggest that the pro-motility protocol not only enhances the success rate of the patency test but may also help minimize the risk of complications related to capsule retention.
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  • * A study analyzed outcomes from 252 patients and found a total of 18 complications (5.7%) from PD, with no significant differences in complication rates between older and younger patients.
  • * The findings suggest that PD is just as safe for older adults as for younger ones, indicating it should be more widely considered as a treatment option for this age group.
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The Crohn's Disease (CD) exclusion diet (CDED) has been shown to induce remission in pediatric and adult patients with CD. In this retrospective cohort study, we describe our real-world experience with the CDED at the inflammatory bowel disease (IBD) unit of the Tel Aviv Medical Center between 2018-2021. CD patients with multiple clinical presentations and disease phenotypes who initiated the diet were included.

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Article Synopsis
  • This study evaluated the safety and effectiveness of video capsule endoscopy (VCE) in older adults, focusing on those aged 65 and over, with a specific comparison between younger elders (65-79 years) and octa-nonagenarians (≥80 years).
  • The research found that octa-nonagenarians had a higher rate of clinically significant findings, such as active bleeding and angioectasia, compared to their younger counterparts, indicating a greater diagnostic yield in this age group.
  • Overall, VCE is deemed safe for octa-nonagenarians, revealing important treatable health issues, with common referrals for anemia and overt bleeding more frequent in older patients.
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Introduction And Objectives: There are inconsistent findings on the association between human non-alcoholic fatty liver disease (NAFLD) and vitamin D, perhaps due to insufficient specificity for gender and obesity status. We aimed to assess whether serum levels of 25-hydroxyvitamin D are associated with unexplained elevated alanine aminotransferase (ALT) in general population across gender and body mass index (BMI) levels.

Materials And Methods: A cross-sectional analysis of a population-based cohort with a nationwide-distribution using electronic medical database.

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Obesity induces low-grade chronic inflammation, manifested by proinflammatory polarization of adipose tissue innate and adaptive resident and recruited immune cells that contribute to insulin resistance (IR). The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that mediates postprandial insulin secretion and has anabolic effects on the adipose tissue. Importantly, recent evidence suggested that GIP is a potential suppressor of inflammation in several metabolic models.

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Background & Aims: Sortilin traffics newly synthesized molecules from the trans-Golgi apparatus along secretory pathways to endosomes, lysosomes or to the cell surface. Sortilin trafficking of acid sphingomyelinase (aSMase) may regulate ceramide levels, a major modulator of insulin signalling. We therefore tested whether sortilin deficiency reduces hepatic and adipose tissue aSMase activity, improving insulin sensitivity in diet-induced obesity (DIO).

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Background: One out of 5 patients undergoing coronary angiography has angiographically normal coronary arteries (ANCA). Some of them have abnormally slow coronary flow (SCF). The prevalence and causes of SCF in these patients are not clear.

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