Language phenotypes in children with autism spectrum disorder, expressive language disorder, and typical language development.

The aim of this study was to compare language abilities in 4-6-year-old Georgian-speaking children with typical language development (TLD), expressive language disorder (ELD), and autism spectrum disorder (ASD). Language linguistic components, such as phonology, semantics, syntax, morphology, and pragmatics, were examined along with verbal behavior types like "mand," "tact," "echoic," and "intraverbal." Our sample comprised 148 children, with a gender distribution of 50 girls and 98 boys.

A six-year longitudinal study of neurocognitive problems in children with epilepsy.

Introduction: This study describes the specific neuropsychological abnormalities among children with epilepsy (CH-E) living in Georgia.

Methods: A cohort of CH-E and children without epilepsy (CH-NoE), aged 6-13 years, admitted to the epilepsy center of the Institute of Neurology and Neuropsychology from 1st January 2010 to 31st December 2015, was selected and investigated with a structured protocol. Neurological/epileptological assessments were made and neuropsychological testing was done on all study subjects.

Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia.

Objective: The cognitive teratogenicity of antiepileptic drugs (AEDs) has gained increasing attention in the last decade. The objective of the current study was to assess the effects of AED fetal exposure on the cognitive development of children of mothers with epilepsy from Georgia in a controlled study taking into consideration major confounding factors.

Methods: A prospective cohort group was formed from children and mothers registered in the Georgian National AED-Pregnancy Registry.

Bitemporal intractable epilepsy: could it be surgically treatable?

Background: The goal of this study is to retrieve the attention to the treatment opportunities for this cohort of intractable bitemporal epilepsy patients who in most cases are not considered optimal candidates for surgery.

Objectives: The purpose of this study is to demonstrate that electrophysiologically guided precise surgeries on both temporal lobes can have a beneficial effect on seizures without additional cognitive decline.

Methods: Twenty-one intractable bitemporal epilepsy patients [13 men, 8 women, mean age 21 years (range 6-43), mean duration of illness 17 years (range 3-31), frequency of seizures 6-55 per month] underwent stereotactic cryosurgery on both temporal lobes guided by chronic and intraoperative depth electrode studies.

Electrophysiological effects and clinical results of direct brain stimulation for intractable epilepsy.

Objective: Epilepsy can be considered as a result of the imbalance of the excitatory and inhibitory processes. Therefore, the artificial enhancement of the activity of brain inhibitory mechanisms might lead to a beneficial therapeutic effect for intractable epilepsy patients.

Material And Methods: Studies of the inhibitory effects of electrical stimulation of the head of the caudate nucleus (HCN), cerebellar dentate nucleus (CDN), thalamic centromedian nucleus (CM), and neocortical and temporal lobe mesiobasal epileptic foci were performed on 150 patients with implanted intracerebral electrodes.