Ru(II)-Catalyzed Redox-Neutral C-H Olefination and Tandem Cyclization with Vinyl Sulfones: Leveraging Sulfinate Anion as a Leaving Group for the Synthesis of 3-Methyleneisoindolin-1-ones.

We developed a Ru(II)-catalyzed redox-neutral C-H olefination of -methoxybenzamides with vinyl sulfones. The reaction is operationally simple and conducted at ambient temperature and does not require silver additives or external oxidants, making it suitable for late-stage functionalization. Notably, we leveraged the leaving group ability of sulfinate anion to synthesize 3-methyleneisoindolin-1-ones through a tandem C-H olefination/cyclization/elimination sequence at ambient temperature.

Reverse Regioselective Cp*Co(III)-Catalyzed [4 + 2] C-H Annulation of -Chloroamides with Vinylsilanes: Synthesis of 4-Silylated Isoquinolones and Their Synthetic Utilities.

We have developed a Cp*Co(III)-catalyzed reverse regioselective [4 + 2] annulation of -chlorobenzamides/acrylamides with vinylsilanes for the synthesis of 4-silylated isoquinolones. The reaction was performed at ambient temperature under redox-neutral conditions. The reaction utilized the N-Cl bond as an internal oxidant, furnished the required products with excellent regioselectivities, and demonstrated high functional group tolerance.

Harnessing Vinyl Acetate as an Acetylene Equivalent in Redox-Neutral Cp*Co(III)-Catalyzed C-H Activation/Annulation for the Synthesis of Isoquinolones and Pyridones.

We have developed Cp*Co(III)-catalyzed redox-neutral synthesis of 3,4-unsubstituted isoquinoline 1(2)-ones at ambient temperature using -chloroamides as a starting material. The reaction utilizes vinyl acetate as an inexpensive and benign acetylene surrogate. The N-Cl bond of the -chlorobenzamides plays the role of an internal oxidant and hence precludes the need for an external oxidant.